Photomicrograph depicting Golgi apparatus (MG-160) staining in vasopressinergic SON neurons of the hypothalamus of (A): a 43-year-old control subject, (B): an 82-year-old control subject, (C): a 49-year-old Alzheimer patient and (D): an 81-year-old Alzheimer patient. Note the increase in size of the Golgi apparatus with age. (from Lucassen et al., 1994, J. Neuroendocrinol. 6, 673-679; with permission).