Live chat Thursday, February 17, noon-1 p.m. EST

Participants: Dean Hartley and Dennis Selkoe of Brigham and Women's Hospital and Harvard Medical School, and William Klein of Northwestern University School of Medicine.

View Transcript of Discussion

Articles under discussion

Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci 1999 Oct 15;19(20):8876-84. Abstract.

Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 1998 May 26;95(11):6448-53. Abstract.

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