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Protein Misfolding: An Unfolding Series of Discussions
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Dominic Walsh led this live discussion on 9 June 2004. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.
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 View Transcript of Live Discussion — Posted 23 August 2006
Background Text
The Alzheimer Research Forum is hosting a succession of live discussions based on
articles in a recent special issue of Current Medicinal
Chemistry-Immunology, Endocrine & Metabolic Agents that focuses on
misfolded proteins in disease. We would like to thank the journal for
its generosity in making full texts of the articles available to
Alzforum members, and to our advisor Dominic Walsh, for helping us
organize this discussion series.
Over the past decade, protein misfolding has emerged as a common theme
linking a growing number of human diseases, including the major
neurodegenerative diseases. In addition, diverse findings, from
familial disease mutations to protein trafficking, seem again and again
to implicate mechanisms involved in the complex cellular machinery that
governs the correct guidance of protein folding and the disposal of
misfolded proteins. These interconnections are outlined in the
introductory article by David R. Howlett of GlaxoSmithKline, titled
"Protein Misfolding in Disease: Cause or Response?" (Download full
text.)
As Dr. Howlett points out, there are numerous compelling pieces of
evidence and mechanisms that suggest a central role for protein
misfolding, but major questions remain to be answered. We invite you to
read Dr. Howlett's article and send us comments and discussion topics
for our 9 June live forum. Please send correspondence to June
Kinoshita, Executive Editor.
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Submit a Comment on this Live Discussion
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