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Could a New Down Syndrome Mouse Model Also Be Useful for Alzheimer Research?
This live discussion was held on the paper by O'Doherty et al., in Science, on "An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes."
Lizzy Fisher and Victor Tybulewicz led this live discussion on 14 October 2005. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.  View Transcript of Live Discussion — Posted 21 November 2005
Because Down syndrome individuals almost invariably develop Alzheimer pathology and, in many cases, dementia, this mouse could provide a novel model system for elucidating mechanisms of AD pathogenesis. The authors report a loss of LTP in hippocampal neurons but so far no obvious AD pathologies such as plaques or hyperphosphorylated tau. Might there be subtler alterations in APP and its many offspring? An increase in ADDLs? Defects in axonal transport? Senior authors Lizzy Fisher and Victor Tybulewicz are eager to brainstorm online with interested Alzheimer scientists. Join them, along with Bill Mobley, John Trojanowski, Cindy Lemere, Dan Geschwind, Barbara Tate and others to ask questions, make suggestions and move forward the evaluation of this new mouse as a possible research model for AD. Or send your questions and comments by email to junekino@alzforum.org.
Reference
O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, Nizetic D, Tybulewicz VL, Fisher EM. An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes. Science. 2005 Sep 23;309(5743):2033-7. Abstract
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