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Home: Research: Forums: Live Discussions
What We Know, What We Don't Know
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What we know

What we don’t know

6.

60 percent of people diagnosed with MCI go on to be diagnosed with AD

Can those with AD be identified while still at the MCI stage?


Comments
Comment by:  Jurgen Claassen (Disclosure)
Submitted 8 May 2007 Posted 1 June 2007

I would be more interested in the 40 percent who do not progress to clinical AD. What is the cause of their cognitive impairment if not AD? Or even more interesting, why did AD not progress from the MCI stage. Do these individuals have disease-limiting phenomena?

View all comments by Jurgen Claassen

Comment by:  Alvin Lyckman
Submitted 8 April 2008 Posted 10 April 2008

This statistic is not meaningful without knowing what percentage of non-MCI people go on to develop AD in the same time frame.

View all comments by Alvin Lyckman

Comment by:  Alvin Lyckman
Submitted 15 April 2008 Posted 22 April 2008

In addition, the significance of MCI to AD and age-related dementias in general requires knowing the prevalence of MCI. Since AD is clearly not inevitable, with or without prior MCI, I agree with Jurgen Classen that further distinguishing the non-progressors will provide critical insight. However, we have yet to establish the epidemiological relationships between sporadic AD and MCI versus non-pathologic aging.

View all comments by Alvin Lyckman
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