What We Know, What We Don't Know


	Current Papers
	ARF Recommends
	Milestone Papers
	Search All Papers
	Search Comments


	Research News
	Drug News
	Conference News


	AD Hypotheses
		AlzSWAN
		Current Hypotheses
		Hypothesis Factory
	Forums
		Live Discussions
		Virtual Conferences
		Interviews
	Enabling Technologies
		Workshops
		Research Tools
	Compendia
		AlzGene
		AlzRisk
		Antibodies
		Biomarkers
		Mutations
		Protocols
		Research Models
		Video Gallery
	Resources
		Bulletin Boards
		Conference Calendar
		Grants
		Jobs


	Overview
	Diagnosis/Genetics
	Research
	News
	Profiles
	Clinics


	Companies
	Tutorial
	Drugs in Clinical Trials


	About Alzheimer's
		FAQs
	Diagnosis
		Clinical Guidelines
		Tests
		Brain Banks
	Treatment
		Drugs and Therapies
	Caregiving
		Patient Care
		Support Directory
		AD Experiences


	Member Directory
	Researcher Profiles
	Institutes and Labs


	Mission
	ARF Team
	ARF Awards
	Advisory Board
	Sponsors
	Partnerships
	Fan Mail
	Support Us

Home: Research: Forums: Live Discussions

What We Know, What We Don't Know

back to table

	What we know	What we don’t know
26.	Abeta is generated by cleavage of APP by beta- and gamma-secretase	Does the cleavage process change with aging or in AD?

	Comments

	Comment by: Michael Wolfe, ARF Advisor
	Submitted 12 February 2007 \| Permalink	Posted 12 February 2007
	I would add that we know that presenilin is the catalytic component of gamma-secretase and thus determines the length of Abeta peptidases. View all comments by Michael Wolfe

	Submit a Comment

Cast your vote and/or make a comment on this page.

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name
*Last Name
Country or Territory:
*Login Email Address
*Password	Minimum of 8 characters
*Confirm Password
Stay signed in?

Comment:

(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)

References:

*Enter the verification code you see in the picture below:

This helps Alzforum prevent automated registrations.

Terms and Conditions of Use:	Printable Version

By clicking on the 'I accept' below, you are agreeing to the Terms and Conditions of Use above.




			Print this page Email this page Alzforum News Papers of the Week Text size Share & Bookmark Del.icio.us Digg Facebook Google Newsvine








			Should the FDA be allowed to use data from overseas clinical trials?

			Absolutely, we are running out of viable subjects in the U.S.
			9

			Yes, so long as the data is reliable
			31

			No, the trials are not as rigorous
			3

			No, the data should be repeated in the U.S.
			5

			No, the drug sponsors are just trying to cut corners
			3

			Responses: 51







			Archived Polls







			Antibodies Cell Lines Collaborators Papers Research Participants