What We Know, What We Don't Know


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What We Know, What We Don't Know

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	What we know	What we don’t know
24.	There is progressive degeneration starting with basal forebrain, entorhinal cortex, to hippocampal formation, parts of limbic system, association cortex, etc.	Why does degeneration follow this pattern? Is there a relationship among the affected regions?

	Comments

	Comment by: Jurgen Claassen (Disclosure)
	Submitted 8 May 2007 \| Permalink	Posted 3 June 2007
	A partial explanation may be vascular: These regions are all innervated by the basal forebrain cholinergic neurons. These neurons have direct and indirect cerebrovascular innervation (vasodilatory in nature). Cholinergic denervation may contribute to hypoperfusion in these regions. In addition, many of these regions are perfused by terminal arteries and may be at higher risk for hypoperfusion when there is coexisting vascular disease. References: Claassen JA and Jansen RW. Cholinergically mediated augmentation of cerebral perfusion in Alzheimer's disease and related cognitive disorders: the cholinergic-vascular hypothesis. J Gerontol A Biol Sci Med Sci. 2006;61(3):267-71. Abstract View all comments by Jurgen Claassen

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