Posted 4 November 2003

General Information

Transgene: Human longest tau cDNA with R406W mutation containing myc and FLAG tags at N-and C-terminal ends, respectively

Mutation:

Promoter: αCaMk-II promoter

Mouse Strain: B6SJL/F1 backcrossing with C57BL/6J

Phenotype

Neuropathological Analysis:

Accumulation of insoluble tau in aged mice. Congophilic hyperphosphorylated tau inclusions only in forebrain neurons of aged mice.

Neurophysiological:

In hippocampal slice preparation, there was attentuation of the Schaffer collateral-evoked neural response.

Behavioral:

Impaired associative memory in contextual and cued fear conditioning test. Abnormality in prepulse inhibition and forced swim test. No overt sensorimotor deficit.

Availability

Patents: None

Reference

Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21): 13896-9. Abstract