Updated 16 January 2009
Transgene: A transgene including a cDNA of the shortest human tau isoform (T44,
also known as fetal tau) driven by the mouse PrP promoter and 3' untranslated sequences
was used to create tau Tg mice on a B6D2/F1 background.
Mutation: Human Tau
Mouse Strain: B6D2-Tg(Prnp-MAPT)43Vle/J
The heterozygous Tg mouse line 43 overexpresses human tau proteins at levels approximately
10 fold higher than endogenous mouse tau. 3- to 12-month-old Tg mice accumulate
insoluble intraneuronal filamentous hyperphosphorylated tau inclusions accompanied
by neurodegeneration in the spinal cord. NFT-like inclusions were first detected
in Tg mice at 18 to 20 months of age and they were detected by Congo red, Thioflavin
S. Observed progressive, age-dependent accumulation of argyrophilic, tau-immunoreactive
inclusions in neurons of spinal cord, brainstem, and neocortex, similar to human
tauopathies. Mice suffer progressive, age-dependant neuronal damage, motor weakness
Homozygous mice died in utero or within 3 months postnatal. Progressive motor weakness,
impaired ability to stand on a slanted surface.
The Jackson Lab
See Jax Datasheet:
Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Trojanowski JQ, Lee VM-Y. Age-Dependent
Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest
Human Tau Isoform. Neuron 24:751-762, 1999.
Ishihara T, Zhang B, Higuchi M, Yoshiyama Y, Trojanowski JQ, Lee V M-Y. Age-Dependent
Induction of Congophilic Neurofibrillary Tau Inclusions in Tau Transgenic Mice.
Am J Pathology 158:555-562, 2001. Abstract.
Ishihara T, Higuchi M, Zhang B, Yoshiyama Y, Hong M, Trojanowski JQ, Lee VM. Attenuated
neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.
J Neurosci. 2001 Aug 15;21(16):6026-35. Abstract.
Nakashima H, Ishihara T, Yokota O, Terada S, Trojanowski JQ, Lee VM, Kuroda S. 2004.
Effects of alpha-tocopherol on an animal model of tauopathies. Free Radic Biol Med.
37 :176-86. Abstract.
Zhang B, Maiti A, Shively S, Lakhani F, Mcdonald-Jones, G, Bruce J, Lee EB, Xie
SX, Joyce S, Li C, Toleikis PM, Lee VMY, Trojanowshi JQ. Microtubule-binding drugs
offset tau sequestration by stabilizing microtubules and reversing fast axonal transport
deficits in a tauopathy model. Proc Natl Acad Sci U S A 102 (1); 227-231, 2005.
Yoshiyama Y, Uryu K, Higuchi M, Longhi L, Hoover R, Fujimoto S, McIntosh T, Lee
VM, Trojanowski JQ. Enhanced neurofibrillary tangle formation, cerebral atrophy,
and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy
mouse model. J Neurotrauma. 2005 Oct;22(10):1134-41.