Posted 18 December 2004

General Information

Transgene: Tau gene transgenic mice expressing human tau proteins were generated by microinjection of PAC 24i13 (Genome Systems Inc., St. Louis) containing the entire human TAU gene (approximately 200 kBp).

Mutation:

Promoter: Human tau

Mouse Strain: C57BL/6 x SJL hybrids and C57BL/6

Phenotype

Neuropathological Analysis:

The mice have increased immunoreactivity to most tau antibodies with some somatodendritic relocalization. No tau aggregates are present. All six of the tau mRNA protein isoforms are expressed and the level of all human tau proteins is 3-4 times higher than the level of endogenous mouse tau protein.

Behavioral:

Hemizygous mice breed normally; homozygous mice have a low level of pregnancies with smaller litters.

Availability

Hana Dawson
Division of Neurology, Dept of Medicine
Duke University, Box 2900 DUMC,
Durham NC 27710
Phone: 919 684 5453
Fax: 919 684 6514
Email: dawso009@mc.duke.edu

Patents:

References

Primary:

Dawson HN, Ferreira A, Eyster MV, Ghoshal N, Binder LI, Vitek MP. Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. J Cell Sci. 114(Pt 6): 1179-87, 2001. Abstract.