Posted 18 December 2004
Transgene: C-N279K mice were created by microinjection of a minigene comprised of
all of the human CNS expressed exons and intronic sequences surrounding exons 2,
3 and 10. The mice express human tau protein at 3-4 times the level of endogenous
mouse tau protein.
Mouse Strain: C57BL/6 x SJL hybrids
Molecularly, tau isoforms are expressed almost exclusively with exon 10 in adult
mice as seen in patients with the mutation.
Division of Neurology, Dept of Medicine
Duke University, Box 2900 DUMC,
Durham NC 27710
Phone: 919 684 5453
Fax: 919 684 6514