Posted 18 December 2004

General Information

Transgene: C-N279K mice were created by microinjection of a minigene comprised of all of the human CNS expressed exons and intronic sequences surrounding exons 2, 3 and 10. The mice express human tau protein at 3-4 times the level of endogenous mouse tau protein.

Mutation: N279K

Promoter: CMV

Mouse Strain: C57BL/6 x SJL hybrids

Phenotype

Neuropathological Analysis:

Molecularly, tau isoforms are expressed almost exclusively with exon 10 in adult mice as seen in patients with the mutation.

Behavioral:

Normal.

Availability

Hana Dawson
Division of Neurology, Dept of Medicine
Duke University, Box 2900 DUMC,
Durham NC 27710
Phone: 919 684 5453
Fax: 919 684 6514
Email: dawso009@mc.duke.edu

Patents:

References

Primary:

Unpublished.