Posted 22 February 2007

General Information

Transgene/Mutation: Mice overexpress human tau 1N2R cDNA with tau mutations (G272V and P301S) under control of the Thy 1.2 promoter. Mice are fertile with normal frequency, size of litters and stably transmits transgene to offspring.

Phenotype

Neuropathological Analysis:

Phenotype memory deficits. Neurofibrillary tangles, PHF and ptau at epitopes MC1, AT100, pS422, 12E8, PHF/AD2, AT8, AT180, AT270. Tau pathology starting in the hippocampus.

Behavioral:

No motor deficit until more than 2 years old.

Availability

Terms and Conditions: Available for academic research but not for private companies. Exclusive MTA already signed with a pharmaceutical company.

Contact: Luc Buee

References

Primary:

Schindowski K, Bretteville A, Leroy K, Begard S, Brion JP, Hamdane M, Buee L. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006 Aug;169(2):599-616. Abstract.