Updated 23 January 2009

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Name/Symbol Strain Name Transgene/ Promoter and Regulatory Elements Genetic Background Behavioral  Phenotype Neurological  Characteristics Patents/ Availability Primary Citation Psen2-EGFP Posted 1/23/09 STOCK Tg(Psen2-EGFP)244Gsat/Mmcd Modified BAC containing inserted EGFP upstream of targeted gene injected into pronuclei of FVB/N fertilized oocytes/ founder line DF244. Background: FVB/N-Swiss Webster hybrid, Generation: N1F2.     MMRRC Cryopreserved stock# 011154-UCD. For non-profit only. Gong et al., 2003 NSE-hPS2(N141I) and hPS2wt   pNSE-CAT promoter and hPS2(N141I) inserted in pUHD10-3/microinjected BDF1 Origin C57BL/6 x DBA/2, Background C57BL/6, Backcross 5 generations Behavior dysfunction in water maze Levels of hPS2, Aβ-42, caspase-3, and Cox-2 expression were modulated in tg and wt. No AD phenotype seen between mutant and wt. Patent filing date 11/4/02 Contact: Yong K Kim kimyongkyu@hanmail.net   Hwang et al., 2002 PS2N141I Symbol: PS2 Posted 6/10/05 Tg.Prp-huPS2.30H Human FAD mutation N141I inserted into PS2 cDNA/ murine prion protein genomic fragment (pPrnpHG) promoter/microinjection into pronuclei B6D2F1 zygotes. Origin C57BL/6, DBA/2. Backcrossed C57BL/6 for 3N, then intercrossed F8 14% mortality before weaning.   Contact: Laurence Ozmen Laurence.ozmen@roche.com Richards et al., 2003 PS2 N141I   Human PS2 cDNA with N141I/ chicken b-actin promoter C57BL/6 (B6)J or DBF1 females and B6N males N/A Age-dependent increase in Aβ42, higher level of insoluble Aβ Unpatented Contact Yasuo Ihara   Oyama et al PS2 null Updated 1/23/09 B6.129P-Psen2tm1Bdes/J Exon 5 was replaced by a hygromycin cassette under the control of the PGK promoter C57B6/J black x 129Sv Viable and fertile no behavioral abnormalities.   No abnormal pathology, develop only mild pulmonary fibrosis and hemorrhage with age. The Jackson Lab, cryopreserved, stock #005617. Use by companies or for-profit entities requires a license prior to shipping. Herreman et al., 1999. PS2 null   Ablated PS2 gene created by the deletion of exon 5 and insertion of the neomycin resistance gene disrupted translation of the mouse gene in ES cells. 129sv/ev x C57/blk6 No behavioral abnormalities No abnormal pathology Unpatented Steiner H et al.