Posted 1 April 2005

General Information

Transgene: Human wild-type mutant cDNAs were cloned into a neuron-specific enolase (NSE) expression vector.

Mutation: Wt hPS1

Promoter: Neuron-specific enolase (NSE) promoter

Mouse Strain: B6D2 F1 hybrids

Phenotype

Neuropathological Analysis:

Line 22 expresses the hPS1 proteins at two to three times the level of the endogenous mPS1. No neuropathological changes have been observed in these mice.

Availability

Gregory A. Elder
Department of Psychiatry
Mount Sinai School of Medicine
New York, NY 10029
Email: gregory.elder@mssm.edu

Patents: None

Primary Reference

Wen, P.H., Shao, X., Shao, Z., Hof, P.R., Wisniewski, T., Kelley, K., Friedrich Jr., V.L., Ho, L., Pasinetti, G.M., Shioi, J., Robakis, N.K. and Elder, G.A. Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice. Neurobiol. Dis. 10:18-19, 2002. ">Abstract

Associated References

Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice. Exp Neurol. 188(2):224-37, 2004. Abstract