Updated 23 January 2009

General Information

Transgene: 1,000 kb YAC transgene with hu PS-1 gene/H163R mutation/J1 ES cells/line G9.

Mutation: H163R mutation

Mouse Strain: B6.129S4-Tg(PSEN1H163R)G9Btla/J, Generation: ?+N34+F2 (08-Jan-09).

Phenotype

Neuropathological Analysis:

Elevated levels of Aβ peptides and earlier Aβ deposition (7 months) are detected in the brains of PSEN1 YAC transgenic when crossed to APP YAC transgenic line R1.40 such as #005300.

Behavioral:

N/A

Availability

The Jackson Lab, available, Stock #006469. For research and non-profit use only.

Patents: None

Reference

Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat Neurosci. 1999 Aug ; 2(8):695-7. Abstract