Updated 23 January 2009
Transgene: 1,000 kb YAC transgene with hu PS-1 gene/H163R mutation/J1 ES cells/line
Mutation: H163R mutation
Mouse Strain: B6.129S4-Tg(PSEN1H163R)G9Btla/J, Generation: ?+N34+F2 (08-Jan-09).
Elevated levels of Aβ peptides and earlier Aβ deposition (7 months) are
detected in the brains of PSEN1 YAC transgenic when crossed to APP YAC transgenic
line R1.40 such as #005300.
The Jackson Lab,
available, Stock #006469. For research and non-profit use only.
Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger
EJ. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1
yeast artificial chromosome transgenic mice. Nat Neurosci. 1999 Aug ; 2(8):695-7.