Posted 15 December 2003

General Information

Transgene: YAC containing entire 100 kb human PSEN1 gene with H163R mutation introduced into J1 ES cells

Mutation: H163R mutation

Mouse Strain: Original background 129S4/SvJae;
Published/distributed Background C57BL/6J;
Generation: N22

Phenotype

Neuropathological Analysis:

Elevated levels of Aβ peptides and earlier Aβ deposition (7 months) are detected in the brains of PSEN1 YAC transgenic when crossed to APP YAC transgenic line R1.40

Behavioral:

N/A

Availability

Bruce Lamb
Departments of Genetics and Neurosciences, Case Western Reserve University
10900 Euclid Avenue, Cleveland, OH 44106-4955, USA
Phone: (216) 368-2979
Fax: (216) 368-3432
Email: btl@po.cwru.edu

Patents: None

Reference

Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ. Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice. Nat Neurosci. 1999 Aug ; 2(8):695-7. Abstract