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Name/ Symbol Strain Name Transgene/ Promoter and Regulatory Elements Genetic Background Behavioral  Phenotype Neurological  Characteristics Patents/  Availability Primary  Citation GRN KO Symbol: PGRN Posted 12/7/10   PGRN gene exons 2-13 replaced with neo-cassette/PGK-1 promoter as positive selection marker and DT-A fragment with thymidine promoter (MC-1) as neg selection marker/E14.1 ES cells. Origin: C57BL/6 x DBF1; Background: C57Bl/6. Viable Ko mice but low birth frequency. Ko mice developed microgliosis, astrogliosis, and tissue vacuolation, with focal neuronal loss and severe gliosis apparent in the oldest mice. Dr. Jada Lewis Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224 Kayasuga et al., 2007 Progranulin cKo Symbol: PGRN Posted 08/13/10   LoxP flanked pgrn locus /BAC vector/CY2.4 ES clones with homozygous C57BL/ TyrC-21 background/ breeding pgrnflox/+ or pgrnflox/flox mice with CAG-Cre results in deletions of pgrn gene, neo/kan cassette and cre-negative. Origin: C57BL/6; Backcross: N >10. Healthy and fertile. Show increased depression- and disinhibition-like behavior. Deficits in social recognition. No deficits in locomotion. Old mice display impaired spatial learning and memory. 12-month mice show progressive development of neuropathology with activation of microglia and astrocytes and accumulation of phos TDP-43. FTD-like neuro-deficits. Aihao Ding: ahding@med.cornell.edu. These mice are in the process of being transferred to The Jackson Laboratory repository. Yin et al., 2010 Yin et al., 2010