Posted 1 April 2005
Transgene: Transgene bearing full-length wt hRAGE driven by the platelet-derived
growth factor (PDGF) β-chain promoter was constructed and subcloned into the
6apc1 vector and injected into mouse B6CBAF1/J oocytes and then implanted into pseudopregnant
females that were subsequently mated with B6CBAF1/J males. The mice were termed
Tg RAGE (or Tg wtRAGE).
Mutation: PDGF-β promoter
Mouse strain: C57BL/6
Receptor for Advanced Glycation Endproducts (RAGE). Tg RAGE mice have overexpression
of transgene from cerebral cortex.
Tg RAGE mice show normal gross development, reproductive fitness and lifespan
Shi Du Yan
Departments of Pathology and Surgery, Departments of Pathology and Surgery
Taub Institute for Alzheimer's Disease and the Aging Brain
College of Physicians & Surgeons of Columbia University
630 West 168th Street
New York, NY 10032, USA.
Phone: (212) 305 3958
Fax: (212) 305 5337
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF,
Stern A, Luddy JS, Lue L-F, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt
AM, Kindy M, Hyslop PA, Stern DM, Yan SSD. RAGE potentiates Aß-induced perturbation
of neuronal function in transgenic mice. The EMBO J. 23 (20): 4096-4105, 2004. Abstract