Posted 1 April 2005

General Information

Transgene: Transgene bearing full-length wt hRAGE driven by the platelet-derived growth factor (PDGF) β-chain promoter was constructed and subcloned into the 6apc1 vector and injected into mouse B6CBAF1/J oocytes and then implanted into pseudopregnant females that were subsequently mated with B6CBAF1/J males. The mice were termed Tg RAGE (or Tg wtRAGE).

Mutation: PDGF-β promoter

Mouse strain: C57BL/6

Phenotype

Neuropathological analysis

Receptor for Advanced Glycation Endproducts (RAGE). Tg RAGE mice have overexpression of transgene from cerebral cortex.

Behavioral

Tg RAGE mice show normal gross development, reproductive fitness and lifespan

Availability

Shi Du Yan
Departments of Pathology and Surgery, Departments of Pathology and Surgery
Taub Institute for Alzheimer's Disease and the Aging Brain
College of Physicians & Surgeons of Columbia University
630 West 168th Street
New York, NY 10032, USA.
Phone: (212) 305 3958
Fax: (212) 305 5337
Email: sdy1@columbia.edu

Patents: None

References

Primary:

Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue L-F, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Yan SSD. RAGE potentiates Aß-induced perturbation of neuronal function in transgenic mice. The EMBO J. 23 (20): 4096-4105, 2004. Abstract