Updated 28 May 2009

General Information

Transgene: Mouse Abca1 (ATP-binding cassette, subfamily A (ABC1), member 1) gene/mouse Prnp (prion protein) promoter/fertilized B6CBAF1 eggs.

Breeding: Origin: 50%C57BL/6:50%CBA. Background, C57BL/6. Generation: N5+ (22-Jan-09). Transgenic mice can be bred by mating female hemizygote to a wild-type male. Male transgenic mice are sterile.

Mouse strain: B6.Cg-Tg(Prnp-Abca1)EHol/J

Phenotype

Neuropathological Analysis:

Founder line E mice have a sixfold increase in expression of ABCA1 in the cortex over wild-type levels; Tg mice exhibit reduced ApoE levels in the hippocampus and cerebrospinal fluid (CSF). When crossed with PDAPP mice the resulting PDAPP/Abca1 Tg mice had (a) decreased deposition of Aβ (b) a near absence of thioflavine S-positive amyloid plaques; and (c) a redistribution of Aβ deposits in the hippocampus from the molecular layer to the hilus of the dentate gyrus.

Behavioral Phenotype:

Not studied.

Availability

Contact: The Jackson Lab, available, stock #008596.

References

Primary:

Wahrle SE, Jiang H, Parsadanian M, Kim J, Li A, Knoten A, Jain S, Hirsch-Reinshagen V, Wellington CL, Bales KR, Paul SM, Holtzman DM. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest. 2008 Feb;118(2):671-82. Abstract