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Home: Research: Compendia: Research Models

Other AD-Related Research Models

Updated 28 May 2009

back to Research Models Index

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Name/ Symbol	Strain Name	Transgene/ Promoter and Regulatory Elements	Genetic Background	Behavioral Phenotype	Neurological Characteristics	Patents/ Availability	Primary Citation
Camk2a-UBB Symbol: Camk2a Posted 05/19/09	C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J	Tg construct containing cDNA encoding the mutant hu ubiquitin B, UBB+ seq/ mouse Camk2a promoter/injected into fertilized C57BL/6 eggs. Founder line 3413-1 with 13 copies of the transgene was subsequently established. mRNA levels for UBB+1 are 49% of endogenous Ubb mRNA levels.	Origin: C57BL/6.	Mice display impaired spatial learning.	Hemizygous tg mice exhibit diminished ubiquitin-proteasome system activity with a resulting increase in ubiquitinated proteins in the cortex.	The Jackson Lab, under development, stock #008833. Use of mice by companies or for-profit entities requires a license prior to shipping.	Fischer et al., 2009
COX 8A/EYFP Symbol: Cox Posted 1/30/09	C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J	COX8A, cytochrome c oxidase subunit 8A/mitochondrial-specific EYFP fusion protein/tetracycline-responsive promoter element (TRE;tetO)/ fertilized C57BL/6 eggs.	Origin: C57BL/6, Generation: N7+F4 (18-Dec-08).	Hemizygotes are viable and fertile.	Expression of EYFP is detected in neuronal mitochondria under appropriate conditions.	The Jackson Lab, available, stock #006618. Companies or for-profit entities require a license prior to shipping. Use of the Tet-System may require a license.	Chandrasekaran et al., 2006
Sortilin-related receptor Symbol: Sorl1 Posted 1/30/09	B6.129P2-Sorl1^Gt(Ex255)Byg/J	Gene trap vector, pGT1tfr, contains the reporter gene beta-geo and has been inserted into exon 47.	Origin: 129P2/OlaHsd, B6.129P2-Sorl1Gt(Ex255)Byg/J, Background: crossed to C57BL, Generation: N7+F3 (21-Oct-08).	Homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.	Mice homozygous for this gene trapped allele exhibit a higher incidence of diffuse immunoreactive β amyloid deposits when compared to wt.	The Jackson Lab, available, stock #007999.	Rohe et al., 2008
Pcsk9, proprotein convertase subtilisin Symbol: Pcsk9 targeted (ko) Posted 1/30/09	B6;129S6-Pcsk9^tm1Jdh/J	Targeting vector containing a neomycin resistance gene replaced the 3' half of exon 2 through exon 4/electroporated into 129S6/SvEvTac-derived SM-1 ES cells/injected into C57BL/6J blastocysts/bred to C57BL/6J.	Origin: 129S6/SvEvTac, Generation: N1+F6 (29-DEC-08).	Homozygous mice are viable and fertile with no behavioral abnormalities.	Homozygotes have reduced plasma cholesterol levels; apolipoprotein B (apoB)-containing low-density liproprotein (LDL) is nearly undetectable and apolipoprotein E (apoE)-containing high density liproprotein (HDL) levels are reduced 30%.	The Jackson Lab, available, stock #005993. Use by companies or for-profit entities requires a license prior to shipping.	Rashid et al., 2005
mNOS2-/- Symbol: iNOS Posted 1/30/09	B6.129P2-Nos2^tm1Lau/J	Calmodulin binding domain replaced with a neomycin resistance gene from pMC1NeopolA/electroporated into 129P2/OlaHsd derived E14TG2a (ES) cells/ injected into C57BL/6J blastocysts.	Donor strain: 129P2, Background: C57BL/6, Generation: N11F10 (20-Dec-06).	Homozygotes resemble wildtype mice in appearance and histology and are viable and fertile.	Homozygotes had virtually no serum NO response.	The Jackson Lab, available, stock #002609.	Laubach et al., 1995
Ngfr, nerve growth factor receptor Symbol: p75-KO Posted 1/30/09	B6.129S4-Ngfr^tm1Jae/J	Neomycin selection cassette inserted into the 3rd exon of the gene, disrupting the sequences encoding cysteine repeats 2, 3, and 4/ 129/Sv-derived J1 ES cell line.	Origin: 129S4/SvJae, Background: C57BL/6J, Generation: N11F13pF3 (08-Jan-09).	Homozygous mice are viable and fertile.	p75-deficient DRG and SCG neurons displayed a 2- to 3-fold decreased sensitivity to NGF at E-15 and postnatal day three, respectively. These ages coincide with the peak of naturally occurring cell death. p75-deficient embryonic hippocampal neurons in culture and forebrain neurons in adult mice are resistant to Aβ(1-42) induced neuronal degeneration.	The Jackson Lab, available, stock #002213. Use by companies or for-profit entities requires a license prior to shipping.	Lee et al., 1992
Dld-/- Symbol: Posted 1/20/09	B6;129P2-Dld^tm1Ptl/J	Exon 10 was disrupted by the insertion of a neomycin selection cassette/E14.1 ES cells/bred to C57BL/6.	Origin: 129P2/OlaHsd, Generation: F?+F1 (02-JAN-09).	Mice heterozygous for the Dld (dihydrolipoamide dehydrogenase or E3 component) targeted mutation are viable and fertile.	Heterozygous mice exhibit ~half of wt enzymatic activity levels for E3 and all affected mitochondrial multienzyme complexes. Heterozygotes (on a C57BL/6;129P2 background) exhibit increased vulnerability to treatments with MPTP (dopaminergic neurotoxin used to induce Parkinson's lesions), malonate (inhibitor of cellular respiration used to mimic Huntington's (HD) features), and 3-NP (mitochondrial toxin used to mimic HD features).	The Jackson Lab, available, stock #008333. Use by companies or for-profit entities requires a license prior to shipping.	Johnson et al., 1997
Neuroglobin/EGFP Symbol: Ngb-Tg Posted 1/20/09	B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J	Mouse neuroglobin/GFP/chicken beta actin promoter (ACTB) with CMV.	Origin: (C57BL/6 x DBA/2)F1 x CD-1, Generation: N5+ (08-SEP-08).	Mice that are homozygous for the targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities.	Tg mice have NGB-overexpressing neurons, astrocytes and endothelial cells in the cerebral cortex.	The Jackson Lab, available, stock #007575.	Khan et al., 2006 Khan et al., 2007
CaMKII-R(AB) Symbol: Posted 1/20/09	B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J	cAMP-dependent protein kinase A (PKA or PRKACA) RIalpha regulatory subunit/Camk2a promoter/ inj into (B6CBAF1/J x B6CBAF1)/bred to C57BL/6J.	Origin: (C57BL/6J x CBA/J)F2.	Mice hemizygous for the transgene are viable and fertile with no gross anatomical abnormalities or structural lesions within the hippocampus or other regions. Mice have defective long-term, but not short-term, memory in hippocampus-based spatial and non-spatial tasks.	Tg expression seen in hippocampus, neocortex, olfactory bulb, striatum, and amygdala. Tg mice have a 50% reduction in basal cAMP-dependent protein kinase A (PKA or PRKACA) activity, defective protein synthesis-dependent late phase of LT potentiation, and reduced place cell stability in hippocampus.	The Jackson Lab, cryopreserved, stock #005855. Use by companies or for-profit entities requires a license prior to shipping.	Abel et al., 1997
CK-p25 Tg Symbol: CDK5R1 GFP Posted 1/9/09	C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J	Tg vector encoding p25, CDK5R1, GFP tag / TRE; tetO promoter/ C57BL/6J fertilized embryos implanted into FVB foster mothers. Male offspring bred to C57BL/6J females, tg-positive mice (line 337).	Origin: C57BL/6J, Backcrossed: C57BL/6J, Generation N20.	Hemizygous tg mice are viable, fertile, normal in size, and do not display any behavioral abnormalities.	This tg strain is designed to breed with Tg(Camk2a-tTA) transgenic mice, (Stock No. 003010). The resulting bitransgenic mice exhibit the hallmark phenotype of Alzheimer's disease; elevated p25/Cdk5 related hyperphosphorylation of tau leading to compromised tau function and progressive tau aggregation.	The Jackson Lab, cryopreserved, stock #005706. Companies or for-profit entities require a license and/or approval before shipping; tet-system license may be required. Agreement between Harvard Med School and Alzheimer Res. Consortium allows any researcher to mate these mice for triple tg mice.	Cruz et al., 2003
ApoJ/clusterin ko Symbol: Clu Posted 1/9/09	B6.Cg-Clu^tm1Jakh/J	Insertion of an HPRT cassette deleted exons 1 and 2 of Clu gene/ 129S2/SvPas-derived D3 ES cells/ C57BL/6J blastocysts / implanted into pseudopregnant (C3H/HeN x C57BL/6J)F1/ backcrossed to CF1 females.	Origin: 129S2/SvPas, Background: Black Swiss outbred strain for one generation and then to C57BL/6J; Generation: N17p (11-Dec-05).	Homozygotes are viable, fertile, normal in size, and do not display any behavioral abnormalities.	This mutant confers less fibrillar amyloid-beta damage and less neuritic dystrophy when bred with Alzheimer's disease model mice compared to control.	The Jackson Lab, cryopreserved, stock #005642. Companies or for-profit entities require a license prior to shipping.	McLaughlin et al., 2000
PrP-mAbca1 line E Symbol: ABCA1 Updated 05/28/09	B6.Cg-Tg(Prnp-Abca1)EHol/J.	Mouse Abca1 (ATP-binding cassette, subfamily A [ABC1], member 1) gene/mouse Prnp (prion protein) promoter.	Origin: 50%C57BL/6: 50%CBA. Background: C57BL/6. Generation: N5+ (22-Jan-09).	None studied.	Founder line E mice have a sixfold increase in expression of ABCA1 in the cortex over wild-type levels; Tg mice exhibit reduced ApoE levels in the hippocampus and cerebrospinal fluid (CSF).	The Jackson Lab, available, stock #008596	Wahrle et al., 2008
Tg-FDD Symbol: FDD Posted 5/23/08		Familial Danish dementia (FDD) form of human BRI2/ inserted into pBS/MoPrP.Xho vector/microinjected into hybrid C3HeB/FeJ mouse embryos.	Background C57BL/6J, backcrossed 10 generations.	Aged (~1 year) animals show abnormal grooming behavior, an arched back and walk with a wide-based gait and shorter steps.	Widespread CAA (~7 months), parenchymal ADan deposition, vascular amyloid deposition, amyloid associated gliosis, tau immunoreactive deposits in neuropil. No NFTs.	Contact Rubin Vidal rvidal@iupui.edu	Vidal et al., 2008
AChE ko Symbol: AchE Updated 1/5/09	129-Ache^tm1Loc/J	Exons 2-5 replaced with neo cassette/R1 ES cells/C57Bl/6	Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl<+>; Generation >10+F2p	Null day 3-4 mice develop fine motor tremors, gait abnormalities, continuous circling. Day 21 no righting reflex, closed eyelids.	Null mice live to 21 days, no AchE activity, normal neuron-muscle junction in 12 day mice.	The Jackson Lab, cryopreserved, stock #005987	Xie et al., 2000
human SIRT1 Symbol: SIRT1 Posted 5/30/06		hSIRT1/RatNSE promoter	C57Bl/6J x SJL/J (B6SJL) F1		Elevation α-secretase activity in cortex. Approximate 2 fold elevation of hSIRT1 expression and decrease of ROCK protein in cortex of 3 month old tg mice.	Contact giulio.pasinetti@mssm.edu	Qin et al., submitted.
Senescence accelerated mouse Symbol: SAM Posted 5/28/06		Inbred AKR/J brothers/sisters led to 3 substrains labeled P for (accelerated senescence) prone and 3 substrains R for (senescence) resistant. From SAM-P/2 new strain SAM-P/8 was developed.	AKR/J strain		SAMP-8 has early onset, irreversible, severe deficits related to learning and memory, but shows low incidence of senile amyloidosia. Increase amount of APP with cDNA sequence having 89.2% homology with human APP.	Contact Harlan Requires a signed MTA	Yagi et al., 1988
GSK3β^S9A Symbol: GSK Posted 6/13/05		Human cDNA coding GSK-3ß (S9A) / mouse Thy1 promoter/pronuclear FVB/N embryos.	Origin: C57BL, Backcross N>7		Over expressed in the CNS a constitutively active kinase resulting in a 2-fold increase of GSK-3β kinase activity. Human GSK-3β (S9A) hyperphosphorylates murine protein tau in the brain after 5-7 months. Rescue of the axonopathy in tau-4R x GSK-3β double tg mice.	Contact Paul Van Dun	Spittaels et al., 2000
α2-Macroglobulin Symbol: MAM Posted 6/10/05		7.5-kb SstI/EcoRI fragment comprising exons 16-19 of the MAM gene/PGK promoter/E14 ES cells.	Origin: C57BL, Backcross N>7	MAM-/- homozygotes are viable and fertile with somewhat sub-normal litter size. No apparent phenotype.		Contact Paul Van Dun	Umans et al., 1995
ADAM10, inactive ADAM10 Symbol:ADAM Posted 6/10/05		minigene cDNA's coding for C-terminally HA-tagged bovine ADAM10 (a disintegrin and metalloproteinase)/ neuron-specific mouse thy1 promoter.	Origin: FVB/N	normal		Not available. Contact Falk Fahrenholz Fax 49-6131-392-5348	Postina et al., 2004
ADAM10 dn (catalytically inactive mutant) Symbol: ADAM Posted 6/10/2005	FVB/N	Minigene cDNA's coding for C-terminally HA-tagged bovine ADAM10 dominant negative form, ADAM10-E384A-HA/ neuron-specific mouse thy1 promoter.	Origin: FVB/N	normal	point mutation in zinc-binding motif. In cultured cells mutant has been shown to inhibit generation of APPsα.	Not available. Contact Falk Fahrenholz Fax 49-6131-392-5348	Postina et al., 2004
APP sw/Tau (P301L)/PS1 (M146V) 3x tg Symbol: APP/Tau/PS1 Updated 05/18/09	B6.Cg-^Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J	APP_{Sw(KM670/671NL)} Tau_(P301L)/Thy-1.2 promoter/ co-microinjected into pronuclei of embryos of PS1_M14VKI mice (TJL #004193).	Origin hybrid: 129/C57Bl/6. Backgrounds on a pure FVB/N and on a pure C57BL/6. Generation N6.	Cognitive impairments by 4 months as retention/retrieval deficits occur prior to any plaques or tangle pathology. Early cognitive deficits can be reversed by immunotherapy.	Age related and progressive plaques and tangles. Deficits in LTP correlate with accumulation of intraneuronal Aβ. Tau and APP expression doubled in homozygous mice in hippocampus and cerebral cortex.	The Jackson Lab, under development, Stock #004807. Use of mice only available to non-profit entities.	Oddo et al., 2003
Tg WtRAGE Symbol: RAGE Posted 4/1/05		Full-length wt hRAGE /PDGF-β promoter/6apc1 vector/microinjected into B6CBAF1/J oocytes	C57BL/6, generation N8	Normal gross development, reproductive fitness and lifespan	Overexpression of Receptor for Advanced Glycation Endproducts (RAGE).	Contact Shi Du Yan	Arancio et al., 2004
Plasminogen activator, urokinase (See JAX datasheet) Symbol: Plau Updated 1/20/09	B6.129S2-Plau^tm1Mlg/J	Targeted mutation/neomycin-resistant gene (neo) replacing all but 23 amino acids of the coding sequence/D3 ES cells.	Origin: 129S2, Background:C57BL/6	Homozygotes develop normally, are fertile and have a normal life span.	Homozygous ko mice have increased levels of Aβ and Aβ in plasma. Brain Aβ levels are not significantly different than controls.	Cryopreserved The Jackson Lab, Stock #002509	Carmeliet et al., 1994
Plasminogen activator, urokinase (See JAX datasheet) Symbol: Plau Updated 1/20/09	FVB.129S2-Plau^tm1Mlg/J	Targeted mutation/neomycin-resistant gene (neo) replacing all but 23 amino acids of the coding sequence/D3 ES cells.	Origin: 129S2, Background: FVB/N	Homozygotes develop normally, are fertile and have a normal life span.	Homozygous ko mice have increased levels of Aβ42 and Aβ40 in plasma. Brain Aβ levels are not significantly different than controls.	Cryopreserved The Jackson Lab, Stock #002329	Carmeliet et al., 1994
Plasminogen activator, urokinase (See JAX datasheet) Symbol: Plau Updated 1/20/09	C.129S2-Plau^tm1Mlg/J	Targeted mutation/neomycin-resistant gene (neo) replacing all but 23 amino acids of the coding sequence/D3 ES cells.	Origin: 129S2, Background: BALB/c	Homozygotes develop normally, are fertile and have a normal life span.	Homozygous ko mice have increased levels of Aβ42 and Aβ40 in plasma. Brain Aβ levels are not significantly different than controls.	Cryopreserved The Jackson Lab, Stock #002328	Carmeliet et al., 1994
Syn-cre (See JAX datasheet) Symbol: Cre Posted 4/1/05	B6.Cg-Tg(Syn1-cre)671Jxm/J	Transgenic construct containing a Cre recombinase gene under the direction of a synapsin promoter.	Origin B6;CBAF1; Background C57BL/6NHsd; Generations 5	Homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.	Recombinase activity is detected in neuronal cells by E12.5.	Available The Jackson Lab, Stock #003966	Zhu et al., 2001
GFAP-cre (See JAX datasheet) Symbol: Cre Posted 4/1/05	FVB-Tg(GFAP-cre)25Mes/J	tg construct having a 2.2Kb 5' flanking region of hGFAP gene, cre coding sequence, SV40 nuclear localization signal, and a portion of mouse protamine (Prm1) gene which supplies intronic sequence and a polyadenylation site.	FVB/N background	Hemizygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous mice are not viable.	Recombination primarily in the CNS, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity also in periportal cells of the liver. Expression occurs in regions of the telencephalon by E13.5. In adult cerebellum, only astrocytes are immunoreactive.	Available The Jackson Lab, Stock #004600	Zhuo et al., 2001
nestin-cre (See JAX datasheet) Symbol: Cre Posted 4/1/05	B6.Cg-Tg(Nes-cre)1Kln/J	Human growth hormone polyadenylation signal and a Cre recombinase gene/ rat nestin promoter and nervous system enhancer present in the second intron of the rat nestin gene.	Origin: B6SJLF2, Backcrossed C57BL/6J, Generation N6+4F2 (2003)	Hemizygous mice are viable, fertile, and normal in size, and display no gross physical or behavioral abnormalities.	Cre is primarily expressed in the central and peripheral nervous system with a few isolated kidney and heart cells also expressing activity. Cre recombinase activity is present in nervous tissue by E11.	Available The Jackson Lab, Stock #003771	Tronche et al., 1999
Cre recombinase (See JAX datasheet) Symbol: Cre Posted 4/1/05	B6.129-Tg(Pcp2-cre)2Mpin/J	Cre gene inserted into exon 4 of Pcp2 gene/ Purkinje cell protein 2 (L7) promoter/ ES R1 cells	Origin B6;129. Background C57BL/6Crl. Generation N4+6F4 (2004)	Homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.	Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons starting at day 6, fully established by 2 to 3 weeks after birth.	Available The Jackson Lab, Stock #004146	Barski et al., 2000
Cyan Fluorescent Protein (See JAX datasheet) Symbol: CFP Posted 4/1/05	B6.Cg-Tg(Thy1-CFP)23Jrs/J	Transgenic construct containing a CFP gene/mouse Thy1 gene promoter/a 6.5 kb fragment from the 5' portion of the Thy1 gene, extending from the promoter to the intron following exon 4. Exon 3 and its flanking introns are absent.	Origin: B6CBAF1, Background: C57BL/6J, Generation N5+6 (2003)	N/A	Mice express a spectral variant of GFP (cyan-CFP) at high levels in motor and sensory neurons, as well as subsets of central neurons. Axons are brightly fluorescent all the way to the termials. No expression in non-neural cells. Strong expression from a mid-gestational stage into adulthood.	Available The Jackson Lab, Stock #003710	Feng et al., 2000
Harlequin Symbol: Pdcd8Hq (programmed cell death 8) Posted 3/6/05	B6CBACa A^w-J/A-Pdcd8^Hq/J	Spontaneous mutation. X chromosome. Hq allele of Pdcd8 has a murine ecotropic proviral insertion in intron 1 beginning at genomic base pair 3432.	Origin: CF1 outbred. Transferred to a B6CBACa-A^w-J/A (B6CBA) background/ Generation N?+5	Hemizygous males, homozygous females and hemizygous females are all viable and fertile.	Progressive degeneration of terminally differentiated cerebellar and retinal neurons. AIF (apoptosis inducing factor) expression is reduced by 80%. Neurons damaged by oxidative stress re-enter the cell cycle before undergoing apoptosis.	Available: The Jackson Lab, Stock # 000501	Klein et al., 2002
Paired-like homeodomain transcription factor 3, aphakia (See JAX datasheet) Symbol: Pitx3^ak Posted 3/6/05	B6 x C57BLKS-Pitx3^ak/J	Spontaneous mutation/ two genomic deletions in the Pitx3 sequence.	Origin: 129/Sv-Kitl^Sl-J strain.	N/A	The mesencephalic dopamine system is malformed; homozygotes fail to develop dopaminergic neurons of the substantia nigra. Mice display motor deficits that are reversed by L-DOPA and evidence of "dopaminergic supersensitivity" in the striatum (Hwang, 2005).	Available The Jackson Lab, Stock #000942	Varnum et al., 1968
Down syndrome model; segmental trisomy 16 Symbol: Ts(17¹⁶)65Dn Updated 3/16/09	B6EiC3Sn a/A-Ts(17¹⁶)65Dn	3 copies of mouse APP/Translocation of distal end of mouse Chr 16 to Chr 17.	Origin: DBA/2J; Generation: N?+N6 (08-Oct-08).	Mice live until adult age. Low birth weight, developmental delay, muscle trembling, male sterility, reduced learning.	APP elevated in cerebral cortex. At 6 months, higher level of Aß in hippocampus and mice show decline in cholinergic phenotype and cognitive deterioration.	The Jackson Lab, Stock #001924. For recipient’s research only, not to be sold to third parties for breeding or any other use.	Davisson et al., 1990
Pin 1 Null Symbol: Pin Updated 1/28/05		Deleted all Pin 1 exons with targeting vector of pLNTK, carrying neomycin, thymidine kinase and Lox-P genes	Origin: 129/SV; Backcross C57BL/6, N 11	Progressive age-dependent motor and behavioral deficits, abnormal limb-clasping reflexes, hunched postures, reduced mobility and eye irritation.	Tau hyperphosphorylation, tau filament formation and neuronal degeneration. Null mice neurons have NFT-like pathologies	Contact Takafumi Uchida	Fujimori et al., 1999
AD11 Anti-NGF Symbol: NGF Posted 7/14/2004	B6.SJL-Tg (AD11-VH) Tg (AD11-VK)	HCMV early promoter region	Origin: C57BL/6 x SJL	Starting from 4 months, age dependent deficits in spatial and recognition memory (Radial maze, Morris water maze, object recognition test)	Cholinergic loss in the basal forebrain, phosphorylated tau and tangles in hippocampal and neurons, accumulation of β-Amyloid in the hippocampus	International Application: WO2000IT00321 07/28/2000 USA application 10/049,306 06/05/2002 Mice available for collaboration agreements, service for fee activity, non exclusive license agreements. Contact F. Giuliani or Simona Capsoni, PhD	Ruberti et al., 2000
2xIDE (See JAX datasheet) Symbol: IDE Updated 1/9/09	C57BL/6-Tg(Camk2a-IDE)1Selk/J	Tg construct of human insulin-degrading enzyme, IDE, gene / mouse Camk2a promoter, and SV40 polyadenylation site sequence/injected into fertilized C57BL/6 oocytes.	Origin: C57BL/6; backcross ~7 generations. Maintained as hemizygote.	Healthy and fertile, no overt phenotypic abnormalities	2 fold IDE expressed. Significant reductions in steady-state levels of soluble AβX-40,-42 in 2-3 month mice that correlated with the magnitude of Aβ burden in APP transgenic crosses (B6.Cg-Tg(PDGFB-APPSwInd)20Lms/J (STOCK# 006293).	Cryopreserved The Jackson Lab Stock# 005087. Companies or for-profit entities require a license prior to shipping.	Leissring et al., 2003
8xNEP (See JAX datasheet) Symbol: MME Updated 1/9/09	C57BL/6-Tg(Camk2a-MME)3Selk/J	Mice express human membrane metallo-endopeptidase (MME)/mouse Camk2a promoter and SV40 polyadenylation sequence/injected into C57BL/6 fertilized oocytes.	Origin: C57BL/6; backcross ~7 generations. Maintained as hemizygote.	Healthy and fertile, no overt phenotypic abnormalities. Tg mice have poor reproductive performance.	Eightfold MME expressed. Reductions in steady-state levels of soluble AβX-40,-42 in 2-3 month. When crossed with B6.Cg-Tg(PDGFB-APPSwInd)20Lms/J (STOCK# 006293) Aβ plaques do not develop in bigenic mice.	Cryopreserved The Jackson Lab Stock #005086. Companies and for-profit entities require a license prior to shipping.	Leissring et al., 2003
Src Kinase p59 (See JAX datasheet) Symbol: Fyn Updated 1/18/05	B6;129S7--Fyn^tm1Sor/J	Targeted mutation	Origin: B6;129S7, backcross F?+18	Mice homozygous for the Fyn^tm1Sor targeted mutation are viable and fertile displaying no overt phenotype.	T cell receptor signaling is defective in Fyn-/- mice. Neurological defects include blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal development.	Available The Jackson Lab: Stock #002385	Stein et al., 1992.
Src Kinase p59 (See JAX datasheet) Symbol: Fyn Updated 1/18/05	129-Fyn^tm1Sor/J	Targeted mutation	Origin: 129S1	Mice homozygous for the Fyn^tm1Sor targeted mutation are viable and fertile displaying no overt phenotype.	T cell receptor signaling is defective in homozygous mutant mice. Neurological defects include blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal development.	Available The Jackson Lab: Stock #002271	Stein et al., 1992.
GFAP-GFP (See JAX datasheet) Symbol: GFP Posted 4/1/05	FVB/N-Tg(GFAPGFP)14Mes/J	Tg mice express a mutant form of GFP (hGFP-S65T) /human astrocyte-specific glial fibrillary acidic protein (GFAP) promoter. This strain is also homozygous for the retinal degeneration allele Pde6b^rd1	Origin: FVB/N, Generation N13 (2003).	N/A	Bright fluorescence is observed in the cell bodies and processes of astrocytes throughout the CNS of hemizygous mice. In addition retinal Mullers cells expressed the GFP transgene in response to degeneration of neighboring photoreceptors.	Available The Jackson Lab, Stock #003257	Zhuo et al., 1997
L7-PCP (See JAX datasheet) Symbol: GFP (green fluorescent protein) Posted 5/19/2004	B6;FVB-Tg(Pcp2-EGFP)146.244Yuza/J	mouse Pcp2, Purkinje cell protein 2 (L7)/ construct with Enhanced Green Fluorescent Protein / fertilized FVB/N mouse eggs.	Origin: B6;FVB background	Mice hemizygous for the transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.	Expression of GFP in dendrites, axons and soma of Purkinje cells. GFP expression mimics endogenous Purkinje cell protein 2 expression pattern. Fluorescence is detectable at embryonic day 17 in Purkinje cells and retinal bipolar cells. Low levels of fluorescence are seen in olfactory periglomerular cells, interpeduncular nucleus and superior colliculus neurons.	Under development The Jackson Lab: Stock #004690	Tomomura et al., 2001
Hb9:GFP-1B (See JAX datasheet) Symbol: GFP (green fluorescent protein) Updated 1/18/05	B6.Cg-Tg(Hlxb9-GFP)1Tmj/J	Hlxb9 promoter/ a 9kb portion of mHlxb9 gene, a GFP open reading frame, and bovine growth hormome polyadenylation site /B6CBAF1 mouse eggs.	Origin: C57BL6/J; Backcrossed 8 generations. Maintained as a hemizygote.	Mice homozygous for the transgenic insert are viable, fertile, do not display any gross behavioral abnormalities, but are smaller in size than wildtype littermates. Homozygous pups have a high mortality rate.	Display distinct expression of GFP in dendrites, axons and soma of spinal motor neurons, allowing identification, isolation and purification of spinal motor neurons by FACS. GFP expression mimics endogenous HLXB9 expression pattern. Fluorescence is detected in axons, dendrites and processes of spinal motor neurons at embryonic day 9.5 to postnatal day 10 aged mice.	Available The Jackson Lab: Stock #005029	Wichterle et al., 2002
EYFP (See JAX datasheet) Symbol: YFP Posted 4/1/2005	129-Tg(ACTB-EYFP)2Nagy/J	Enhanced Yellow Fluorescent Protein gene/chicken beta actin promoter coupled with the CMV immediate early enhancer/ R1 embryonic stem (ES) cells.		Homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.	Hemizygous mice display fluorescence in all tissue cell types under appropriate lighting conditions. Homozygotes exhibit double the fluorescent intensity. In erythrocytes and adipocytes fluorescence is negligible or absent.	Available The Jackson Lab: Stock #005483	Hadjantonakis et al., 2002
Yellow Fluorescent Protein (See JAX datasheet) Symbol: YFP Posted 2/26/2004	B6.Cg-Tg(Thy1-YFP)16Jrs/J	Construct of YFP/Thy1promoter/ injected into fertilized B6CBAF1 mouse eggs.	Origin: mixed B6CBAF1. Backcross to C57BL/6J, N5+5F3 generation.		High levels of FYP in motor,sensory neurons and subsets of central neurons. No expression in nonneural cells. Strong and specific vital marker for axons; fluorescence is stable to aldehyde fixation.	Available The Jackson Lab: Stock #003709	Feng et al., 2000
Yellow Fluorescent Protein (See JAX datasheet) Symbol: YFP Posted 2/26/2004	B6.Cg-Tg(Thy1-YFPH)2Jrs/J Common Strain Name: eYFP-H, Line H	Construct of YFP/Thy1promoter/ injected into fertilized B6CBAF1 mouse eggs.	Origin: mixed B6CBAF1. Backcross to C57BL/6J, N5+N5 generation.		High levels of FYP in motor,sensory neurons and subsets of central neurons. No expression in nonneural cells. Strong and specific "Golgi-like" vital marker for neuronal subsets, with minimal labeling of nearby axons.	Available The Jackson Lab: Stock #003782	Feng et al., 2000
Parkin-Null Symbol: PRKN Posted 4/18/2004		Knockout mouse Parkin gene (exon 3)/replaced with pPN2T plasmid +Neo and TK selection/CK35 ES cells	Background 129SV or 129SV-C57/Bl6 (Crl) Backcross C57/BL6 (Crl)	Mice are viable and fertile. Display abnormal motor activity, decreased weight and temperature.	Cognitive deficits. Endogenous dopamine increased, increased metabolism of dopamine by MAO. No loss of nigrostiatal dopamine neurons, but transporter protein reduced.	Patents: Application FR 0212395, October 2, 2002 Available Contact: Thomas A. Rooney	Itier et al., 2003
Parkin-Null Symbol: PRKN Posted 2/17/2004		Deleted Parkin mutation/replaced with EGFP sequence/PGK-neo/J1 (129/Sv) ES cells.	Pure 129/Sv and C57BL/6 and 129/Sv hybrid. Backcross to C57BL/6 >10 generations	Viable and fertile, no obvious abnormalitites. No alterations in general behavior and exploratory anxiety. Exhibit deficits in tasks sensitive to nigrostriatal pathway.	Normal brain morphology, increased extracellular dopamine in striatum, reduced synaptic reaction in spiny striatal neurons. Dopaminergic neurons normal to 24 months.	Available Contact Jie Shen	Goldberg et al., 2003
Quaking (See JAX datasheet) Symbol: Qk^qk Posted 2/12/2004	B6C3Fe a/a-Qk^qk/J	Spontaneous mutation: Parkin gene (PRKN) and Parkin Co-Regulated Gene (PACRG) deleted.	Origin: B6C3	Reduced locomotor/exploratory activity.	Mice exhibit rapid tremor during locomotion. Tremor begins at day 10, fully developed by 3 weeks. Older mice have seizures. CNS is deficient in myelin, PNS less severe myelin deficiency.	Available The Jackson Lab: Stock 000506	Sidman et al., 1964 Lockhart et al., 2004
Bdnf^2lox (See JAX datasheet) Symbol: Bdnf Posted 12/30/2003	STOCK Bdnf^tm2Jae/J	loxP sites on either side of exon 5 of the targeted gene/ cytomegalovirus promoter /J1 ES cells	Origin: mixed C;129S4. Background mixed B6, 129S4, BALB/c.	Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.	When used in conjunction with Cre recombinase-expressing strains, this line is useful in generating tissue-specific and/or developmentally-regulated knockouts of Bdnf.	Available The Jackson Lab: Stock 004339	Rios et al., 2001
B6-Gabra1 (See JAX datasheet) Symbol: Gabra1 Posted 12/30/03	B6.129(FVB)-Gabra1^tm1Geh/J	Targeting vector loxP for the α1 null allele (-/-) and the cre transgene/R1 ES cells	Origin: B6;129, Crossed to FVB/N and then C57BL/6 for N6	Homozygous mice for this Gabra1 allele are viable, fertile, and normal in size. No gross physical or behavioral abnormalities	When used in conjunction with Cre recombinase-expressing strains, this line is useful in generating tissue-specific and/or developmentally-regulated knockouts of the alpha1 subunit of the GABA receptor.	Available The Jackson Lab: Stock 004318	Vicini et al., 2001
Galanin		pDGF				Unpatented	Blakeman K et al., 2001
GalOE (See JAX datasheet) Symbol: Gal Updated 1/9/09	B6.Cg-Tg(DBH-Gal)1923Stei/J	4.6 Kb sequence of mouse galanin gene/5.8 Kb sequence of hu dopamine α-hydroxylase promoter/ fertilized SJL X C57BL/6 eggs.	Origin: (SJL x C57BL/6)F1; Generation: N8F1N1+N1p (20-Nov-05).	Homozygous mice are viable, normal in size and do not display any gross physical or behavioral abnormalities.	5x increase in galanin mRNA levels in the locus coeruleus region and a 2x increase in peptide level in the forebrain. Decrease in basal forebrain cholinergic neurons. Exhibit impaired learning and memory.	Cryopreserved The Jackson Lab: Stock 004996	Mazarati et al, 2000
GIN (GFP-expressing Inhibitory Neurons) (See JAX datasheet) Symbol: GFP Posted 11/11/03	FVB-Tg(GadGFP)45704Swn/J	tg construct of 5' mGad1gene/GFP/SV40 injected into FVB/N mouse eggs.	FVB/NHsd background. Homozygote x Homozygote	Homozygous mice exhibit no apparent physical or behavioral defects.	Transgene expression occurs in a specific subpopulation of hippocampal and cortical GABAergic interneurons that express somatostatin.	Available The Jackson Lab: Stock 003718	Oliva et al, 2000
Neprilysin				Normal in reproductive, developmental and physiological aspects.		Unpatented	Iwata N et al., 2001
NSE-p25 line A (See JAX datasheet) Symbol: Cdk5r1 Updated 1/9/09	FFVB/N-Tg(Eno2CDK5R1)1Jdm/J	Human p25 fragment obtained from full-length p35 clone/rat NSE promoter	homozygote on a FVB/N background (N6)	Mice exhibit whole-body tremors at 4-9 weeks of age and enhanced open-field locomotor activity	Expression of the amino terminal proteolytic fragment p25 of hCDK5R1 is detected in the amygdala, thalamus/hypothalamus, cerebral cortex, and cerebellum. A 2-fold increase in the catalytic activity of Cdk5 is sufficient to produce hyper-phosphorylation of tau and neurofilament as well as cytoskeletal disruptions	Cryopreserved The Jackson Lab: Stock 003753. Companies or for-profit entities require a license prior to shipping.	Ahlijanian et al., 2000
p35 or D11Bwg0379e (See Jax datasheet) Symbol: Cdk5r Updated 1/9/09	B6.129S4-Cdk5r^tm1Lht/J	Deleted the genomic p35 locus by replacing the entire p35-coding region with the (neo^R) gene in the opposite transcriptional orientation. Targeting construct electroporated into J1 ES cells	Origin B6;129S4; Backcross C57BL/6; Generation: N5F?+4pN1 (15-Feb-04).	No behavior abnormalities. Homozygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.	The normal lamination pattern of cortical neurons is disrupted; axonal trajectories and dendritic structures are altered.	Cryopreserved The Jackson Lab: Stock 004163. Companies or for-profit entities require a license prior to shipping.	Chae et al., 1997
TGF-β1 T64 Symbol: TGFβ1 Posted 9/30/2004		TGFβ1 secreted as bioactive peptide/mouseGFAP	Origin: BALB/c x SJL. Background: C57BL/6J, 10 generations	Homozygous mice display neurological complications such as tremors, seizures, incoordination, runting and severe hydrocephalus.	Transgene copy number: approximately 1; mRNA levels: -/+ 100 +/+ 700; Hydrocephalus: 5-20 % penetrance in heterozygous mice depending on strain; 100% penetrance in homozygous mice. Other pathology: Cerebrovascular astrocytosis and amyloid deposition is age- and dose-related.	Contact Tony Wyss-Coray twc@stanford.edu	Wyss-Coray et al., 1995
TGF-β1 T115 (AKA T65) Symbol: TGFβ1 Posted 9/30/2004		TGFβ1 secreted as bioactive peptide/mouseGFAP	Origin: BALB/c x SJL. Background: C57BL/6J, 10 generations		Transgene copy number: approximately 10; mRNA levels: -/+ 200 +/+ 400; Hydrocephalus: Never observed; Other pathology: Cerebrovascular astrocytosis and amyloid deposition is age- and dose-related.	Contact Tony Wyss-Coray twc@stanford.edu	Lesne et al., 2003
Transforming growth factor β1 (See JAX datasheet) Symbol: TGFβ1 null Posted 8/27/2004	B6.129S2-Tgfβ1^tm1Doe/J	The vector targeted neo insertion into exon 6 of the Tgfβ1 gene/129-derived D3 ES cells.	Origin: Backcrossed 10 or more times to C57BL/6J inbred mice.	Homozygous mice develop normally but die within 2-3 weeks of birth from wasting syndrome (massive inflammatory response and tissue necrosis		Available The Jackson Lab: Stock # 002220	Shull et al., 1992.
Transforming growth factor β1 (See JAX datasheet) Symbol: Tgfb1 Posted 8/27/2004	STOCK Tgfβ1^tm1Doe/J1	The vector targeted neo insertion into exon 6 of the Tgfβ1 gene/ 129-derived D3 ES cell.	Origin: Mixture of random bred CF1 mice, inbred 129 and inbred C57BL/6.	Homozygotes, by 2-3 weeks, succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death.	Homozygous mice show no gross developmental abnormalities.	Available The Jackson Lab: Stock # #002098 Heterozygous may be ordered	Shull et al., 1992.





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