Name/
Symbol
|
Strain Name
|
Transgene/
Promoter and Regulatory Elements
|
Genetic Background
|
Behavioral
Phenotype
|
Neurological
Characteristics
|
Patents/
Availability
|
Primary
Citation
|
|
Camk2a-UBB
Symbol: Camk2a
Posted 05/19/09
|
C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J
|
Tg construct containing cDNA encoding the mutant hu ubiquitin B, UBB+ seq/ mouse
Camk2a promoter/injected into fertilized C57BL/6 eggs. Founder line 3413-1 with
13 copies of the transgene was subsequently established. mRNA levels for UBB+1 are
49% of endogenous Ubb mRNA levels.
|
Origin: C57BL/6.
|
Mice display impaired spatial learning.
|
Hemizygous tg mice exhibit diminished ubiquitin-proteasome system activity with
a resulting increase in ubiquitinated proteins in the cortex.
|
The Jackson Lab,
under development, stock #008833. Use of mice by companies or for-profit entities
requires a license prior to shipping.
|
Fischer et al., 2009
|
|
COX 8A/EYFP
Symbol: Cox
Posted 1/30/09
|
C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
|
COX8A, cytochrome c oxidase subunit 8A/mitochondrial-specific EYFP fusion
protein/tetracycline-responsive promoter element (TRE;tetO)/ fertilized C57BL/6
eggs.
|
Origin: C57BL/6, Generation: N7+F4 (18-Dec-08).
|
Hemizygotes are viable and fertile.
|
Expression of EYFP is detected in neuronal mitochondria under appropriate conditions.
|
The Jackson Lab,
available, stock #006618. Companies or for-profit entities require a license prior
to shipping. Use of the Tet-System may require a license.
|
Chandrasekaran et al.,
2006
|
|
Sortilin-related receptor
Symbol: Sorl1
Posted 1/30/09
|
B6.129P2-Sorl1Gt(Ex255)Byg/J
|
Gene trap vector, pGT1tfr, contains the reporter gene beta-geo and has been inserted
into exon 47.
|
Origin: 129P2/OlaHsd, B6.129P2-Sorl1Gt(Ex255)Byg/J, Background: crossed to C57BL,
Generation: N7+F3 (21-Oct-08).
|
Homozygous mice are viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities.
|
Mice homozygous for this gene trapped allele exhibit a higher incidence of diffuse
immunoreactive β amyloid deposits when compared to wt.
|
The Jackson Lab,
available, stock #007999.
|
Rohe et al., 2008
|
|
Pcsk9, proprotein convertase subtilisin
Symbol: Pcsk9 targeted (ko)
Posted 1/30/09
|
B6;129S6-Pcsk9tm1Jdh/J
|
Targeting vector containing a neomycin resistance gene replaced the 3' half of exon
2 through exon 4/electroporated into 129S6/SvEvTac-derived SM-1 ES cells/injected
into C57BL/6J blastocysts/bred to C57BL/6J.
|
Origin: 129S6/SvEvTac, Generation: N1+F6 (29-DEC-08).
|
Homozygous mice are viable and fertile with no behavioral abnormalities.
|
Homozygotes have reduced plasma cholesterol levels; apolipoprotein B (apoB)-containing
low-density liproprotein (LDL) is nearly undetectable and apolipoprotein E (apoE)-containing
high density liproprotein (HDL) levels are reduced 30%.
|
The Jackson Lab,
available, stock #005993. Use by companies or for-profit entities requires a license
prior to shipping.
|
Rashid et al., 2005
|
mNOS2 ko
(See JAX datasheet)
Symbol: iNOS
Posted 06/14/10
|
B6;129P2-Nos2tm1Lau/J
|
Targeting construct was designated as pSPKO-NOS. The ApaI-KpnI fragment containing
the calmodulin-binding domain of Nos2 was replaced by the neomycin resistance gene.
|
Origin: 129P2/OlaHsd. Generation: F36 (21-Jan-10).
|
Homozygotes resemble wild-type mice in appearance and histology and are viable and
fertile.
|
Homozygotes had virtually no serum NO response.
|
The Jackson Lab,
available, stock #002596.
|
Laubach et al., 1995
|
mNOS2 ko
(See JAX datasheet)
Symbol: iNOS
Posted 06/14/10
|
CBy.129P2(B2)-Nos2tm1Lau/J
|
A neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding
domain.
|
Origin: 129P2/OlaHsd. Backcross: C57BL/6. Generation: N5F2 (17-Nov-09).
|
Homozygotes resemble wild-type mice in appearance and histology and are viable and
fertile.
|
Homozygotes had virtually no serum Nitric Oxide response.
|
The Jackson Lab,
available, stock #007072.
|
Laubach et al., 1995
|
|
mNOS2-/-
Symbol: iNOS
Posted 1/30/09
|
B6.129P2-Nos2tm1Lau/J
|
Calmodulin binding domain replaced with a neomycin resistance gene from pMC1NeopolA/electroporated
into 129P2/OlaHsd derived E14TG2a (ES) cells/ injected into C57BL/6J blastocysts.
|
Donor strain: 129P2, Background: C57BL/6, Generation: N11F10 (20-Dec-06).
|
Homozygotes resemble wildtype mice in appearance and histology and are viable and
fertile.
|
Homozygotes had virtually no serum NO response.
|
The Jackson Lab,
available, stock #002609.
|
Laubach et al., 1995
|
|
Ngfr, nerve growth factor receptor
Symbol: p75-KO
Posted 1/30/09
|
B6.129S4-Ngfrtm1Jae/J
|
Neomycin selection cassette inserted into the 3rd exon of the gene, disrupting the
sequences encoding cysteine repeats 2, 3, and 4/ 129/Sv-derived J1 ES cell line.
|
Origin: 129S4/SvJae, Background: C57BL/6J, Generation: N11F13pF3 (08-Jan-09).
|
Homozygous mice are viable and fertile.
|
p75-deficient DRG and SCG neurons displayed a 2- to 3-fold decreased sensitivity
to NGF at E-15 and postnatal day three, respectively. These ages coincide with the
peak of naturally occurring cell death. p75-deficient embryonic hippocampal neurons
in culture and forebrain neurons in adult mice are resistant to Aβ(1-42) induced
neuronal degeneration.
|
The Jackson Lab,
available, stock #002213. Use by companies or for-profit entities requires a license
prior to shipping.
|
Lee et al., 1992
|
|
Dld-/-
Symbol:
Posted 1/20/09
|
B6;129P2-Dldtm1Ptl/J
|
Exon 10 was disrupted by the insertion of a neomycin selection cassette/E14.1 ES
cells/bred to C57BL/6.
|
Origin: 129P2/OlaHsd, Generation: F?+F1 (02-JAN-09).
|
Mice heterozygous for the Dld (dihydrolipoamide dehydrogenase or E3 component)
targeted mutation are viable and fertile.
|
Heterozygous mice exhibit ~half of wt enzymatic activity levels for E3 and all affected
mitochondrial multienzyme complexes. Heterozygotes (on a C57BL/6;129P2 background)
exhibit increased vulnerability to treatments with MPTP (dopaminergic neurotoxin
used to induce Parkinson's lesions), malonate (inhibitor of cellular respiration
used to mimic Huntington's (HD) features), and 3-NP (mitochondrial toxin used to
mimic HD features).
|
The Jackson Lab,
available, stock #008333. Use by companies or for-profit entities requires a license
prior to shipping.
|
Johnson et al., 1997
|
|
Neuroglobin/EGFP
Symbol: Ngb-Tg
Posted 1/20/09
|
B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
|
Mouse neuroglobin/GFP/chicken beta actin promoter (ACTB) with CMV.
|
Origin: (C57BL/6 x DBA/2)F1 x CD-1, Generation: N5+ (08-SEP-08).
|
Mice that are homozygous for the targeted mutation are viable, normal in size and
do not display any gross physical or behavioral abnormalities.
|
Tg mice have NGB-overexpressing neurons, astrocytes and endothelial cells in the
cerebral cortex.
|
The Jackson Lab,
available, stock #007575.
|
Khan et al., 2006
Khan et al., 2007
|
|
CaMKII-R(AB)
Symbol:
Posted 1/20/09
|
B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J
|
cAMP-dependent protein kinase A (PKA or PRKACA) RIalpha regulatory subunit/Camk2a
promoter/ inj into (B6CBAF1/J x B6CBAF1)/bred to C57BL/6J.
|
Origin: (C57BL/6J x CBA/J)F2.
|
Mice hemizygous for the transgene are viable and fertile with no gross anatomical
abnormalities or structural lesions within the hippocampus or other regions. Mice
have defective long-term, but not short-term, memory in hippocampus-based spatial
and non-spatial tasks.
|
Tg expression seen in hippocampus, neocortex, olfactory bulb, striatum, and amygdala.
Tg mice have a 50% reduction in basal cAMP-dependent protein kinase A (PKA or PRKACA)
activity, defective protein synthesis-dependent late phase of LT potentiation, and
reduced place cell stability in hippocampus.
|
The Jackson Lab,
cryopreserved, stock #005855. Use by companies or for-profit entities requires a
license prior to shipping.
|
Abel et al., 1997
|
|
CK-p25 Tg
Symbol: CDK5R1 GFP
Posted 1/9/09
|
C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
|
Tg vector encoding p25, CDK5R1, GFP tag / TRE; tetO promoter/ C57BL/6J fertilized
embryos implanted into FVB foster mothers. Male offspring bred to C57BL/6J females,
tg-positive mice (line 337).
|
Origin: C57BL/6J, Backcrossed: C57BL/6J, Generation N20.
|
Hemizygous tg mice are viable, fertile, normal in size, and do not display any behavioral
abnormalities.
|
This tg strain is designed to breed with Tg(Camk2a-tTA) transgenic mice, (Stock No. 003010). The resulting bitransgenic mice exhibit
the hallmark phenotype of Alzheimer's disease; elevated p25/Cdk5 related hyperphosphorylation
of tau leading to compromised tau function and progressive tau aggregation.
|
The Jackson Lab,
cryopreserved, stock #005706. Companies or for-profit entities require a license
and/or approval before shipping; tet-system license may be required. Agreement between
Harvard Med School and Alzheimer Res. Consortium allows any researcher to mate these
mice for triple tg mice.
|
Cruz et al., 2003
|
|
ApoJ/clusterin ko
Symbol: Clu
Posted 1/9/09
|
B6.Cg-Clutm1Jakh/J
|
Insertion of an HPRT cassette deleted exons 1 and 2 of Clu gene/ 129S2/SvPas-derived
D3 ES cells/ C57BL/6J blastocysts / implanted into pseudopregnant (C3H/HeN x C57BL/6J)F1/
backcrossed to CF1 females.
|
Origin: 129S2/SvPas, Background: Black Swiss outbred strain for one generation and
then to C57BL/6J; Generation: N17p (11-Dec-05).
|
Homozygotes are viable, fertile, normal in size, and do not display any behavioral
abnormalities.
|
This mutant confers less fibrillar amyloid-beta damage and less neuritic dystrophy
when bred with Alzheimer's disease model mice compared to control.
|
The Jackson Lab,
cryopreserved, stock #005642. Companies or for-profit entities require a license
prior to shipping.
|
McLaughlin et al., 2000
|
|
PrP-mAbca1 line E
Symbol: ABCA1
Updated 05/28/09
|
B6.Cg-Tg(Prnp-Abca1)EHol/J.
|
Mouse Abca1 (ATP-binding cassette, subfamily A [ABC1], member 1) gene/mouse Prnp
(prion protein) promoter.
|
Origin: 50%C57BL/6: 50%CBA. Background: C57BL/6. Generation: N5+ (22-Jan-09).
|
None studied.
|
Founder line E mice have a sixfold increase in expression of ABCA1 in the cortex
over wild-type levels; Tg mice exhibit reduced ApoE levels in the hippocampus and
cerebrospinal fluid (CSF).
|
The Jackson Lab,
available, stock #008596
|
Wahrle et al., 2008
|
|
Tg-FDD
Symbol: FDD
Posted 5/23/08
|
|
Familial Danish dementia (FDD) form of human BRI2/ inserted into pBS/MoPrP.Xho vector/microinjected
into hybrid C3HeB/FeJ mouse embryos.
|
Background C57BL/6J, backcrossed 10 generations.
|
Aged (~1 year) animals show abnormal grooming behavior, an arched back and walk
with a wide-based gait and shorter steps.
|
Widespread CAA (~7 months), parenchymal ADan deposition, vascular amyloid deposition,
amyloid associated gliosis, tau immunoreactive deposits in neuropil. No NFTs.
|
Contact Rubin Vidal rvidal@iupui.edu
|
Vidal et al., 2008
|
|
AChE ko
Symbol: AchE
Updated 1/5/09
|
129-Achetm1Loc/J
|
Exons 2-5 replaced with neo cassette/R1 ES cells/C57Bl/6
|
Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl<+>; Generation >10+F2p
|
Null day 3-4 mice develop fine motor tremors, gait abnormalities, continuous circling.
Day 21 no righting reflex, closed eyelids.
|
Null mice live to 21 days, no AchE activity, normal neuron-muscle junction in 12
day mice.
|
The Jackson Lab,
cryopreserved, stock #005987
|
Xie et al., 2000
|
|
human SIRT1
Symbol: SIRT1
Posted 5/30/06
|
|
hSIRT1/RatNSE promoter
|
C57Bl/6J x SJL/J (B6SJL) F1
|
|
Elevation α-secretase activity in cortex. Approximate 2 fold elevation of hSIRT1
expression and decrease of ROCK protein in cortex of 3 month old tg mice.
|
Contact giulio.pasinetti@mssm.edu
|
Qin et al., submitted.
|
|
Senescence accelerated mouse
Symbol: SAM
Posted 5/28/06
|
|
Inbred AKR/J brothers/sisters led to 3 substrains labeled P for (accelerated senescence)
prone and 3 substrains R for (senescence) resistant. From SAM-P/2 new strain SAM-P/8
was developed.
|
AKR/J strain
|
|
SAMP-8 has early onset, irreversible, severe deficits related to learning and memory,
but shows low incidence of senile amyloidosia. Increase amount of APP with cDNA
sequence having 89.2% homology with human APP.
|
Contact Harlan
Requires a signed MTA
|
Yagi et al., 1988
|
|
GSK3βS9A
Symbol: GSK
Posted 6/13/05
|
|
Human cDNA coding GSK-3ß (S9A) / mouse Thy1 promoter/pronuclear FVB/N embryos.
|
Origin: C57BL, Backcross N>7
|
|
Over expressed in the CNS a constitutively active kinase resulting in a 2-fold increase
of GSK-3β kinase activity. Human GSK-3β (S9A) hyperphosphorylates murine
protein tau in the brain after 5-7 months. Rescue of the axonopathy in tau-4R x
GSK-3β double tg mice.
|
Contact Paul Van Dun
|
Spittaels et al., 2000
|
|
α2-Macroglobulin
Symbol: MAM
Posted 6/10/05
|
|
7.5-kb SstI/EcoRI fragment comprising exons 16-19 of the MAM gene/PGK
promoter/E14 ES cells.
|
Origin: C57BL, Backcross N>7
|
MAM-/- homozygotes are viable and fertile with somewhat sub-normal litter size.
No apparent phenotype.
|
|
Contact Paul Van Dun
|
Umans et al., 1995
|
|
ADAM10, inactive ADAM10
Symbol:ADAM
Posted 6/10/05
|
|
minigene cDNA's coding for C-terminally HA-tagged bovine ADAM10 (a disintegrin and
metalloproteinase)/ neuron-specific mouse thy1 promoter.
|
Origin: FVB/N
|
normal
|
|
Not available.
Contact Falk Fahrenholz
Fax 49-6131-392-5348
|
Postina et al., 2004
|
|
ADAM10 dn (catalytically inactive mutant)
Symbol: ADAM
Posted 6/10/2005
|
FVB/N
|
Minigene cDNA's coding for C-terminally HA-tagged bovine ADAM10 dominant negative
form, ADAM10-E384A-HA/ neuron-specific mouse thy1 promoter.
|
Origin: FVB/N
|
normal
|
point mutation in zinc-binding motif. In cultured cells mutant has been shown to
inhibit generation of APPsα.
|
Not available.
Contact Falk Fahrenholz
Fax 49-6131-392-5348
|
Postina et al., 2004
|
APP sw/Tau (P301L)/PS1 (M146V)
3x tg
Symbol: APP/Tau/PS1
Updated 05/24/2010
|
B6;129-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa/J
|
APPSw(KM670/671NL) Tau(P301L)/Thy-1.2 promoter/ co-microinjected
into pronuclei of embryos of PS1M14VKI mice (TJL #004193).
|
Origin hybrid: 129/C57Bl/6. Backgrounds on a pure FVB/N and on a pure C57BL/6. Generation
N6.
|
Cognitive impairments by 4 months as retention/retrieval deficits occur prior to
any plaques or tangle pathology. Early cognitive deficits can be reversed by immunotherapy.
|
Age related and progressive plaques and tangles. Deficits in LTP correlate with
accumulation of intraneuronal Aβ. Tau and APP expression doubled in homozygous
mice in hippocampus and cerebral cortex.
|
The Jackson Lab,
available, Stock #004807. Use of mice only available to non-profit entities.
|
Oddo et al., 2003
|
|
Tg WtRAGE
Symbol: RAGE
Posted 4/1/05
|
|
Full-length wt hRAGE /PDGF-β promoter/6apc1 vector/microinjected into B6CBAF1/J
oocytes
|
C57BL/6, generation N8
|
Normal gross development, reproductive fitness and lifespan
|
Overexpression of Receptor for Advanced Glycation Endproducts (RAGE).
|
Contact Shi Du Yan
|
Arancio et al., 2004
|
Plasminogen activator, urokinase
(See JAX datasheet)
Symbol: Plau
Updated 1/20/09
|
B6.129S2-Plautm1Mlg/J
|
Targeted mutation/neomycin-resistant gene (neo) replacing all but 23 amino acids
of the coding sequence/D3 ES cells.
|
Origin: 129S2, Background:C57BL/6
|
Homozygotes develop normally, are fertile and have a normal life span.
|
Homozygous ko mice have increased levels of Aβ and Aβ in plasma. Brain
Aβ levels are not significantly different than controls.
|
Cryopreserved The
Jackson Lab, Stock #002509
|
Carmeliet et al., 1994
|
Plasminogen activator, urokinase
(See JAX datasheet)
Symbol: Plau
Updated 1/20/09
|
FVB.129S2-Plautm1Mlg/J
|
Targeted mutation/neomycin-resistant gene (neo) replacing all but 23 amino acids
of the coding sequence/D3 ES cells.
|
Origin: 129S2, Background: FVB/N
|
Homozygotes develop normally, are fertile and have a normal life span.
|
Homozygous ko mice have increased levels of Aβ42 and Aβ40 in plasma. Brain
Aβ levels are not significantly different than controls.
|
Cryopreserved The
Jackson Lab, Stock #002329
|
Carmeliet et al., 1994
|
Plasminogen activator, urokinase
(See JAX datasheet)
Symbol: Plau
Updated 1/20/09
|
C.129S2-Plautm1Mlg/J
|
Targeted mutation/neomycin-resistant gene (neo) replacing all but 23 amino acids
of the coding sequence/D3 ES cells.
|
Origin: 129S2, Background: BALB/c
|
Homozygotes develop normally, are fertile and have a normal life span.
|
Homozygous ko mice have increased levels of Aβ42 and Aβ40 in plasma. Brain
Aβ levels are not significantly different than controls.
|
Cryopreserved The
Jackson Lab, Stock #002328
|
Carmeliet et al., 1994
|
Syn-cre
(See JAX datasheet)
Symbol: Cre
Posted 4/1/05
|
B6.Cg-Tg(Syn1-cre)671Jxm/J
|
Transgenic construct containing a Cre recombinase gene under the direction of a
synapsin promoter.
|
Origin B6;CBAF1; Background C57BL/6NHsd; Generations 5
|
Homozygous mice are viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities.
|
Recombinase activity is detected in neuronal cells by E12.5.
|
Available The Jackson Lab, Stock
#003966
|
Zhu et al., 2001
|
GFAP-cre
(See JAX datasheet)
Symbol: Cre
Posted 4/1/05
|
FVB-Tg(GFAP-cre)25Mes/J
|
tg construct having a 2.2Kb 5' flanking region of hGFAP gene, cre coding sequence,
SV40 nuclear localization signal, and a portion of mouse protamine (Prm1) gene which
supplies intronic sequence and a polyadenylation site.
|
FVB/N background
|
Hemizygous mice are viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities. Homozygous mice are not viable.
|
Recombination primarily in the CNS, affecting astrocytes, oligodendroglia, ependyma
and some neurons. Expression activity also in periportal cells of the liver. Expression
occurs in regions of the telencephalon by E13.5. In adult cerebellum, only astrocytes
are immunoreactive.
|
Available The Jackson Lab, Stock
#004600
|
Zhuo et al., 2001
|
nestin-cre
(See JAX datasheet)
Symbol: Cre
Posted 4/1/05
|
B6.Cg-Tg(Nes-cre)1Kln/J
|
Human growth hormone polyadenylation signal and a Cre recombinase gene/ rat nestin
promoter and nervous system enhancer present in the second intron of the rat nestin
gene.
|
Origin: B6SJLF2, Backcrossed C57BL/6J, Generation N6+4F2 (2003)
|
Hemizygous mice are viable, fertile, and normal in size, and display no gross physical
or behavioral abnormalities.
|
Cre is primarily expressed in the central and peripheral nervous system
with a few isolated kidney and heart cells also expressing activity. Cre
recombinase activity is present in nervous tissue by E11.
|
Available The Jackson Lab, Stock
#003771
|
Tronche et al., 1999
|
Cre recombinase
(See JAX datasheet)
Symbol: Cre
Posted 4/1/05
|
B6.129-Tg(Pcp2-cre)2Mpin/J
|
Cre gene inserted into exon 4 of Pcp2 gene/ Purkinje cell protein
2 (L7) promoter/ ES R1 cells
|
Origin B6;129. Background C57BL/6Crl. Generation N4+6F4 (2004)
|
Homozygous mice are viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities.
|
Recombinase activity is observed in most Purkinje cells and some retinal bipolar
neurons starting at day 6, fully established by 2 to 3 weeks after birth.
|
Available The Jackson Lab, Stock
#004146
|
Barski et al., 2000
|
Cyan Fluorescent Protein
(See JAX datasheet)
Symbol: CFP
Posted 4/1/05
|
B6.Cg-Tg(Thy1-CFP)23Jrs/J
|
Transgenic construct containing a CFP gene/mouse Thy1 gene promoter/a 6.5
kb fragment from the 5' portion of the Thy1 gene, extending from the promoter
to the intron following exon 4. Exon 3 and its flanking introns are absent.
|
Origin: B6CBAF1, Background: C57BL/6J, Generation N5+6 (2003)
|
N/A
|
Mice express a spectral variant of GFP (cyan-CFP) at high levels in motor and sensory
neurons, as well as subsets of central neurons. Axons are brightly fluorescent all
the way to the termials. No expression in non-neural cells. Strong expression from
a mid-gestational stage into adulthood.
|
Available The Jackson Lab, Stock
#003710
|
Feng et al., 2000
|
Harlequin
Symbol: Pdcd8Hq (programmed cell death 8)
Posted 3/6/05
|
B6CBACa Aw-J/A-Pdcd8Hq/J
|
Spontaneous mutation. X chromosome. Hq allele of Pdcd8 has a murine ecotropic proviral
insertion in intron 1 beginning at genomic base pair 3432.
|
Origin: CF1 outbred. Transferred to a B6CBACa-Aw-J/A (B6CBA) background/
Generation N?+5
|
Hemizygous males, homozygous females and hemizygous females are all viable and fertile.
|
Progressive degeneration of terminally differentiated cerebellar and retinal neurons.
AIF (apoptosis inducing factor) expression is reduced by 80%. Neurons damaged by
oxidative stress re-enter the cell cycle before undergoing apoptosis.
|
Available: The Jackson
Lab, Stock # 000501
|
Klein et al., 2002
|
Paired-like homeodomain transcription factor 3, aphakia
(See JAX datasheet)
Symbol: Pitx3ak
Posted 3/6/05
|
B6 x C57BLKS-Pitx3ak/J
|
Spontaneous mutation/ two genomic deletions in the Pitx3 sequence.
|
Origin: 129/Sv-KitlSl-J strain.
|
N/A
|
The mesencephalic dopamine system is malformed; homozygotes fail to develop dopaminergic
neurons of the substantia nigra. Mice display motor deficits that are reversed by
L-DOPA and evidence of "dopaminergic supersensitivity" in the striatum (Hwang, 2005).
|
Available The Jackson
Lab, Stock #000942
|
Varnum et al., 1968
|
Down syndrome model; segmental trisomy 16
Symbol: Ts(1716)65Dn
Updated 3/16/09
|
B6EiC3Sn a/A-Ts(1716)65Dn
|
3 copies of mouse APP/Translocation of distal end of mouse Chr 16 to Chr 17.
|
Origin: DBA/2J; Generation: N?+N6 (08-Oct-08).
|
Mice live until adult age. Low birth weight, developmental delay, muscle trembling,
male sterility, reduced learning.
|
APP elevated in cerebral cortex. At 6 months, higher level of Aß in hippocampus
and mice show decline in cholinergic phenotype and cognitive deterioration.
|
The Jackson Lab,
Stock #001924. For recipient’s research only, not to be sold to third parties for
breeding or any other use.
|
Davisson et al., 1990
|
Pin 1 Null
Symbol: Pin
Updated 1/28/05
|
|
Deleted all Pin 1 exons with targeting vector of pLNTK, carrying neomycin, thymidine
kinase and Lox-P genes
|
Origin: 129/SV; Backcross C57BL/6, N 11
|
Progressive age-dependent motor and behavioral deficits, abnormal limb-clasping
reflexes, hunched postures, reduced mobility and eye irritation.
|
Tau hyperphosphorylation, tau filament formation and neuronal degeneration. Null
mice neurons have NFT-like pathologies
|
Contact Takafumi Uchida
|
Fujimori et al., 1999
|
AD11 Anti-NGF
Symbol: NGF
Posted 7/14/2004
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B6.SJL-Tg (AD11-VH)
Tg (AD11-VK)
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HCMV early promoter region
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Origin: C57BL/6 x SJL
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Starting from 4 months, age dependent deficits in spatial and recognition memory
(Radial maze, Morris water maze, object recognition test)
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Cholinergic loss in the basal forebrain, phosphorylated tau and tangles in hippocampal
and neurons, accumulation of β-Amyloid in the hippocampus
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International Application:
WO2000IT00321
07/28/2000
USA application
10/049,306
06/05/2002
Mice available for collaboration
agreements, service for fee activity,
non exclusive license agreements.
Contact F. Giuliani
or Simona Capsoni, PhD
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Ruberti et al., 2000
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2xIDE
(See JAX datasheet)
Symbol: IDE
Updated 1/9/09
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C57BL/6-Tg(Camk2a-IDE)1Selk/J
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Tg construct of human insulin-degrading enzyme, IDE, gene / mouse Camk2a promoter,
and SV40 polyadenylation site sequence/injected into fertilized C57BL/6 oocytes.
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Origin: C57BL/6; backcross ~7 generations. Maintained as hemizygote.
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Healthy and fertile, no overt phenotypic abnormalities
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2 fold IDE expressed. Significant reductions in steady-state levels of soluble AβX-40,-42
in 2-3 month mice that correlated with the magnitude of Aβ burden in APP transgenic
crosses (B6.Cg-Tg(PDGFB-APPSwInd)20Lms/J (STOCK# 006293).
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Cryopreserved
The Jackson Lab
Stock# 005087. Companies or for-profit entities require a license prior to shipping.
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Leissring et al., 2003
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8xNEP
(See JAX datasheet)
Symbol: MME
Updated 1/9/09
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C57BL/6-Tg(Camk2a-MME)3Selk/J
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Mice express human membrane metallo-endopeptidase (MME)/mouse Camk2a promoter
and SV40 polyadenylation sequence/injected into C57BL/6 fertilized oocytes.
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Origin: C57BL/6; backcross ~7 generations. Maintained as hemizygote.
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Healthy and fertile, no overt phenotypic abnormalities. Tg mice have poor reproductive
performance.
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Eightfold MME expressed. Reductions in steady-state levels of soluble AβX-40,-42
in 2-3 month. When crossed with B6.Cg-Tg(PDGFB-APPSwInd)20Lms/J (STOCK# 006293) Aβ plaques do not develop in bigenic mice.
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Cryopreserved
The Jackson Lab
Stock #005086. Companies and for-profit entities require a license prior to shipping.
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Leissring et al., 2003
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Src Kinase p59
(See JAX datasheet)
Symbol: Fyn
Updated 1/18/05
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B6;129S7--Fyntm1Sor/J
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Targeted mutation
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Origin: B6;129S7, backcross F?+18
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Mice homozygous for the Fyntm1Sor targeted mutation are viable
and fertile displaying no overt phenotype.
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T cell receptor signaling is defective in Fyn-/- mice. Neurological defects include
blunted long-term potentiation (LTP), impaired special learning, and altered hippocampal
development.
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Available
The Jackson Lab: Stock #002385
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Stein et al., 1992.
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Src Kinase p59
(See JAX datasheet)
Symbol: Fyn
Updated 1/18/05
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129-Fyntm1Sor/J
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Targeted mutation
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Origin: 129S1
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Mice homozygous for the Fyntm1Sor targeted mutation are viable
and fertile displaying no overt phenotype.
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T cell receptor signaling is defective in homozygous mutant mice. Neurological defects
include blunted long-term potentiation (LTP), impaired special learning, and altered
hippocampal development.
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Available
The Jackson Lab: Stock #002271
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Stein et al., 1992.
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GFAP-GFP
(See JAX datasheet)
Symbol: GFP
Posted 4/1/05
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FVB/N-Tg(GFAPGFP)14Mes/J
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Tg mice express a mutant form of GFP (hGFP-S65T) /human astrocyte-specific glial
fibrillary acidic protein (GFAP) promoter. This strain is also homozygous for the
retinal degeneration allele Pde6brd1
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Origin: FVB/N, Generation N13 (2003).
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N/A
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Bright fluorescence is observed in the cell bodies and processes of astrocytes throughout
the CNS of hemizygous mice. In addition retinal Mullers cells expressed the GFP
transgene in response to degeneration of neighboring photoreceptors.
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Available The Jackson Lab, Stock
#003257
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Zhuo et al., 1997
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L7-PCP
(See JAX datasheet)
Symbol: GFP (green fluorescent protein)
Posted 5/19/2004
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B6;FVB-Tg(Pcp2-EGFP)146.244Yuza/J
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mouse Pcp2, Purkinje cell protein 2 (L7)/ construct with Enhanced Green
Fluorescent Protein / fertilized FVB/N mouse eggs.
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Origin: B6;FVB background
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Mice hemizygous for the transgene are viable, fertile, normal in size and do not
display any gross physical or behavioral abnormalities.
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Expression of GFP in dendrites, axons and soma of Purkinje cells. GFP expression
mimics endogenous Purkinje cell protein 2 expression pattern. Fluorescence is detectable
at embryonic day 17 in Purkinje cells and retinal bipolar cells. Low levels of fluorescence
are seen in olfactory periglomerular cells, interpeduncular nucleus and superior
colliculus neurons.
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Under development
The Jackson Lab:
Stock #004690
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Tomomura et al., 2001
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Hb9:GFP-1B
(See JAX datasheet)
Symbol: GFP (green fluorescent protein)
Updated 1/18/05
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B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
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Hlxb9 promoter/ a 9kb portion of mHlxb9 gene, a GFP open reading
frame, and bovine growth hormome polyadenylation site /B6CBAF1 mouse eggs.
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Origin: C57BL6/J; Backcrossed 8 generations. Maintained as a hemizygote.
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Mice homozygous for the transgenic insert are viable, fertile, do not display any
gross behavioral abnormalities, but are smaller in size than wildtype littermates.
Homozygous pups have a high mortality rate.
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Display distinct expression of GFP in dendrites, axons and soma of spinal motor
neurons, allowing identification, isolation and purification of spinal motor neurons
by FACS. GFP expression mimics endogenous HLXB9 expression pattern. Fluorescence
is detected in axons, dendrites and processes of spinal motor neurons at embryonic
day 9.5 to postnatal day 10 aged mice.
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Available
The Jackson Lab:
Stock #005029
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Wichterle et al., 2002
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EYFP
(See JAX datasheet)
Symbol: YFP
Posted 4/1/2005
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129-Tg(ACTB-EYFP)2Nagy/J
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Enhanced Yellow Fluorescent Protein gene/chicken beta actin promoter coupled with
the CMV immediate early enhancer/ R1 embryonic stem (ES) cells.
|
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Homozygous mice are viable, fertile, normal in size and do not display any gross
physical or behavioral abnormalities.
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Hemizygous mice display fluorescence in all tissue cell types under appropriate
lighting conditions. Homozygotes exhibit double the fluorescent intensity. In erythrocytes
and adipocytes fluorescence is negligible or absent.
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Available
The Jackson Lab:
Stock #005483
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Hadjantonakis et al.,
2002
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Yellow Fluorescent Protein
(See JAX datasheet)
Symbol: YFP
Posted 2/26/2004
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B6.Cg-Tg(Thy1-YFP)16Jrs/J
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Construct of YFP/Thy1promoter/ injected into fertilized B6CBAF1 mouse eggs.
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Origin: mixed B6CBAF1. Backcross to C57BL/6J, N5+5F3 generation.
|
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High levels of FYP in motor,sensory neurons and subsets of central neurons. No expression
in nonneural cells. Strong and specific vital marker for axons; fluorescence is
stable to aldehyde fixation.
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Available
The Jackson Lab:
Stock #003709
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Feng et al., 2000
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Yellow Fluorescent Protein
(See JAX datasheet)
Symbol: YFP
Posted 2/26/2004
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B6.Cg-Tg(Thy1-YFPH)2Jrs/J
Common Strain Name: eYFP-H, Line H
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Construct of YFP/Thy1promoter/ injected into fertilized B6CBAF1 mouse eggs.
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Origin: mixed B6CBAF1. Backcross to C57BL/6J, N5+N5 generation.
|
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High levels of FYP in motor,sensory neurons and subsets of central neurons. No expression
in nonneural cells. Strong and specific "Golgi-like" vital marker for neuronal subsets,
with minimal labeling of nearby axons.
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Available
The Jackson Lab:
Stock #003782
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Feng et al., 2000
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Parkin-Null
Symbol: PRKN
Posted 4/18/2004
|
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Knockout mouse Parkin gene (exon 3)/replaced with pPN2T plasmid +Neo and TK selection/CK35
ES cells
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Background 129SV or 129SV-C57/Bl6 (Crl) Backcross C57/BL6 (Crl)
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Mice are viable and fertile. Display abnormal motor activity, decreased weight and
temperature.
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Cognitive deficits. Endogenous dopamine increased, increased metabolism of dopamine
by MAO. No loss of nigrostiatal dopamine neurons, but transporter protein reduced.
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Patents: Application FR 0212395, October 2, 2002
Available
Contact:
Thomas A. Rooney
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Itier et al., 2003
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Parkin-Null
Symbol: PRKN
Posted 2/17/2004
|
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Deleted Parkin mutation/replaced with EGFP sequence/PGK-neo/J1 (129/Sv)
ES cells.
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Pure 129/Sv and C57BL/6 and 129/Sv hybrid. Backcross to C57BL/6 >10 generations
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Viable and fertile, no obvious abnormalitites. No alterations in general behavior
and exploratory anxiety. Exhibit deficits in tasks sensitive to nigrostriatal pathway.
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Normal brain morphology, increased extracellular dopamine in striatum, reduced synaptic
reaction in spiny striatal neurons. Dopaminergic neurons normal to 24 months.
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Available
Contact Jie Shen
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Goldberg et al., 2003
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Quaking
(See JAX datasheet)
Symbol: Qkqk
Posted 2/12/2004
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B6C3Fe a/a-Qkqk/J
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Spontaneous mutation: Parkin gene (PRKN) and Parkin Co-Regulated Gene (PACRG) deleted.
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Origin: B6C3
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Reduced locomotor/exploratory activity.
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Mice exhibit rapid tremor during locomotion. Tremor begins at day 10, fully developed
by 3 weeks. Older mice have seizures. CNS is deficient in myelin, PNS less severe
myelin deficiency.
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Available
The Jackson Lab:
Stock 000506
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Sidman et al., 1964
Lockhart et al., 2004
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Bdnf2lox
(See JAX datasheet)
Symbol: Bdnf
Posted 12/30/2003
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STOCK Bdnftm2Jae/J
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loxP sites on either side of exon 5 of the targeted gene/ cytomegalovirus
promoter /J1 ES cells
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Origin: mixed C;129S4. Background mixed B6, 129S4, BALB/c.
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Mice that are homozygous for this allele are viable, fertile, normal in size and
do not display any gross physical or behavioral abnormalities.
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When used in conjunction with Cre recombinase-expressing strains, this
line is useful in generating tissue-specific and/or developmentally-regulated knockouts
of Bdnf.
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Available
The Jackson Lab:
Stock 004339
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Rios et al., 2001
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B6-Gabra1
(See JAX datasheet)
Symbol: Gabra1
Posted 12/30/03
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B6.129(FVB)-Gabra1tm1Geh/J
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Targeting vector loxP for the α1 null allele (-/-) and the cre
transgene/R1 ES cells
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Origin: B6;129, Crossed to FVB/N and then C57BL/6 for N6
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Homozygous mice for this Gabra1 allele are viable, fertile, and normal
in size. No gross physical or behavioral abnormalities
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When used in conjunction with Cre recombinase-expressing strains, this line is useful
in generating tissue-specific and/or developmentally-regulated knockouts of the
alpha1 subunit of the GABA receptor.
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Available
The Jackson Lab:
Stock 004318
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Vicini et al., 2001
|
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Galanin
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pDGF
|
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Unpatented
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Blakeman K et al.,
2001
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GalOE
(See JAX datasheet)
Symbol: Gal
Updated 1/9/09
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B6.Cg-Tg(DBH-Gal)1923Stei/J
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4.6 Kb sequence of mouse galanin gene/5.8 Kb sequence of hu dopamine α-hydroxylase
promoter/ fertilized SJL X C57BL/6 eggs.
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Origin: (SJL x C57BL/6)F1; Generation: N8F1N1+N1p (20-Nov-05).
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Homozygous mice are viable, normal in size and do not display any gross physical
or behavioral abnormalities.
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5x increase in galanin mRNA levels in the locus coeruleus region and a 2x increase
in peptide level in the forebrain. Decrease in basal forebrain cholinergic neurons.
Exhibit impaired learning and memory.
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Cryopreserved
The Jackson Lab:
Stock 004996
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Mazarati et al, 2000
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GIN (GFP-expressing Inhibitory Neurons)
(See JAX datasheet)
Symbol: GFP
Posted 11/11/03
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FVB-Tg(GadGFP)45704Swn/J
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tg construct of 5' mGad1gene/GFP/SV40 injected into FVB/N mouse eggs.
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FVB/NHsd background. Homozygote x Homozygote
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Homozygous mice exhibit no apparent physical or behavioral defects.
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Transgene expression occurs in a specific subpopulation of hippocampal and cortical
GABAergic interneurons that express somatostatin.
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Available
The Jackson Lab: Stock 003718
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Oliva et al, 2000
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Neprilysin
|
|
|
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Normal in reproductive, developmental and physiological aspects.
|
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Unpatented
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Iwata N et al., 2001
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NSE-p25 line A
(See JAX datasheet)
Symbol: Cdk5r1
Updated 1/9/09
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FFVB/N-Tg(Eno2CDK5R1)1Jdm/J
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Human p25 fragment obtained from full-length p35 clone/rat NSE promoter
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homozygote on a FVB/N background (N6)
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Mice exhibit whole-body tremors at 4-9 weeks of age and enhanced open-field locomotor
activity
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Expression of the amino terminal proteolytic fragment p25 of hCDK5R1 is detected
in the amygdala, thalamus/hypothalamus, cerebral cortex, and cerebellum. A 2-fold
increase in the catalytic activity of Cdk5 is sufficient to produce hyper-phosphorylation
of tau and neurofilament as well as cytoskeletal disruptions
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Cryopreserved
The Jackson Lab:
Stock 003753. Companies or for-profit entities require a license prior to shipping.
|
Ahlijanian et al., 2000
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p35 or D11Bwg0379e
(See Jax datasheet)
Symbol: Cdk5r
Updated 1/9/09
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B6.129S4-Cdk5rtm1Lht/J
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Deleted the genomic p35 locus by replacing the entire p35-coding region with the
(neoR) gene in the opposite transcriptional orientation. Targeting construct
electroporated into J1 ES cells
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Origin B6;129S4; Backcross C57BL/6; Generation: N5F?+4pN1 (15-Feb-04).
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No behavior abnormalities. Homozygous mice are viable, fertile, normal in size,
and do not display any gross physical or behavioral abnormalities.
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The normal lamination pattern of cortical neurons is disrupted; axonal trajectories
and dendritic structures are altered.
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Cryopreserved
The Jackson Lab:
Stock 004163. Companies or for-profit entities require a license prior to shipping.
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Chae et al., 1997
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TGF-β1 T64
Symbol: TGFβ1
Posted 9/30/2004
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TGFβ1 secreted as bioactive peptide/mouseGFAP
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Origin: BALB/c x SJL. Background: C57BL/6J, 10 generations
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Homozygous mice display neurological complications such as tremors, seizures, incoordination,
runting and severe hydrocephalus.
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Transgene copy number: approximately 1; mRNA levels: -/+ 100 +/+ 700; Hydrocephalus:
5-20 % penetrance in heterozygous mice depending on strain; 100% penetrance in homozygous
mice. Other pathology: Cerebrovascular astrocytosis and amyloid deposition is age-
and dose-related.
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Contact Tony Wyss-Coray
twc@stanford.edu
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Wyss-Coray et al.,
1995
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TGF-β1 T115 (AKA T65)
Symbol: TGFβ1
Posted 9/30/2004
|
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TGFβ1 secreted as bioactive peptide/mouseGFAP
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Origin: BALB/c x SJL. Background: C57BL/6J, 10 generations
|
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Transgene copy number: approximately 10; mRNA levels: -/+ 200 +/+ 400; Hydrocephalus:
Never observed; Other pathology: Cerebrovascular astrocytosis and amyloid deposition
is age- and dose-related.
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Contact Tony Wyss-Coray
twc@stanford.edu
|
Lesne et al., 2003
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Transforming growth factor β1
(See JAX datasheet)
Symbol: TGFβ1 null
Posted 8/27/2004
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B6.129S2-Tgfβ1tm1Doe/J
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The vector targeted neo insertion into exon 6 of the Tgfβ1 gene/129-derived
D3 ES cells.
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Origin: Backcrossed 10 or more times to C57BL/6J inbred mice.
|
Homozygous mice develop normally but die within 2-3 weeks of birth from wasting
syndrome (massive inflammatory response and tissue necrosis
|
|
Available
The Jackson Lab: Stock # 002220
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Shull et al., 1992.
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Transforming growth factor β1
(See JAX datasheet)
Symbol: Tgfb1
Posted 8/27/2004
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STOCK Tgfβ1tm1Doe/J1
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The vector targeted neo insertion into exon 6 of the Tgfβ1
gene/ 129-derived D3 ES cell.
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Origin: Mixture of random bred CF1 mice, inbred 129 and inbred C57BL/6.
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Homozygotes, by 2-3 weeks, succumb to a wasting syndrome accompanied by a multifocal,
mixed inflammatory cell response and tissue necrosis, leading to organ failure and
death.
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Homozygous mice show no gross developmental abnormalities.
|
Available
The Jackson Lab: Stock # #002098
Heterozygous may be ordered
|
Shull et al., 1992.
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