Posted 10 June 2005

General Information

Transgene: The cDNA's coding for C-terminally HA-tagged bovine ADAM10 (a disintegrin and metalloproteinase) were cloned under control of a neuron-specific mouse thy1 promoter. The minigenes were microinjected into pronuclear embryos from superovulated FVB/N females.

Mutation: Mouse Thy1

Mouse strain: FVB/N

Phenotype

Behavioral

normal

Availability

Not available. For information on these mice, please contact:
Falk Fahrenholz
Institute of Biochemistry
University of Mainz
Becherweg 30, D-55099 Mainz, Germany
Fax: 49-6131-392-5348
Email: bio.chemie@uni-mainz.de

References

Primary:

Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. J. Clin. Invest. 113: 1456-1464, 2004. Abstract

Associated:

Moechars, D. Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 274:6483-6492, 1999. Abstract