Posted 1 April 2005

General Information

Transgene: Tg RAGE mice (see Yan) were crossed with animals expressing a mutant form of hAPP (Tg mAPP, (see TJL #004661) driven by PDGFβ-chain promoter, and in the C57BL/6 background.

Promoter: PDGF-β promoter for both RAGE and APP

Mouse strain: C57BL/6

Phenotype

Neuropathological analysis

TBigenic tg APP/RAGE mice displayed early abnormalities in spatial learning/memory, accompanied by altered activation of markers of synaptic plasticity and exaggerated neuropathologic findings, before such changes were found in single mAPP mice.

Availability

Shi Du Yan
Departments of Pathology and Surgery, Departments of Pathology and Surgery
Taub Institute for Alzheimer's Disease and the Aging Brain
College of Physicians & Surgeons of Columbia University
630 West 168th Street
New York, NY 10032, USA.
Phone: (212) 305 3958
Fax: (212) 305 5337
Email: sdy1@columbia.edu

Patents: None

References

Primary:

Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue L-F, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Yan SSD. RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice. The EMBO J. 23 (20): 4096-4105, 2004. Abstract