Posted 10 June 2005
Transgene: For the generation of double-transgenic mice, single-transgenic APPV717I
mice (strain FVB/N) (Moechars, D) were intercrossed with ADAM10-dn animals.
Promoter: Mouse Thy1
Mouse strain: FVB/N
Bigenic mice having moderate neuronal overexpression of ADAM10 showed increased
secretion of the neurotrophic soluble α-secretase-released N-terminal APP domain
(APPsα), reduced formation of Aβ peptides, and prevented their deposition
in plaques. Functionally, impaired long-term potentiation and cognitive deficits
Improved performance in Morris Water Maze test as compared to APPV717I
Not available. For information on these mice, please contact:
Institute of Biochemistry
University of Mainz
Becherweg 30, D-55099 Mainz, Germany
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres
K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz
F. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal
defects in an Alzheimer disease mouse model. J. Clin. Invest. 113: 1456-1464, 2004.
Moechars, D. Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I,
Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F. Early phenotypic
changes in transgenic mice that overexpress different mutants of amyloid precursor
protein in brain. J. Biol. Chem. 274:6483-6492, 1999.