Updated 17 June 2010

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Name/ Symbol Strain Name Transgene/ Promoter and Regulatory Elements Genetic Background Behavioral  Phenotype Neurological  Characteristics Patents/  Availability Primary Citation Cox-1 (See Taconic datasheet) Symbol: Cox-1 Updated 3/12/09 B6;129P2-Ptgs1tm1Unc The Ptgs1 gene that encodes COX-1 has been inactivated by gene-targeting. E14TG2a ES cells Origin: B6;129P2 COX-1 mice develop normally and appear healthy. Homozygous mutant females mated to homozygous mutant males produce few live offspring. Unknown Available. Taconic Stock 002180-M (homozygotes) Stock 002180-T (heterozygotes) For research purposes only. For breeding must have a Research Crossbreeding Agreement with Taconic. No distribution to third parties. Langenbach et al., 1995 Cox-2 (See Taconic datasheet) Symbol: Cox-2 Updated 3/12/09 B6;129P2-Ptgs1tm1Smi The Ptgs2 gene that encodes COX-2 has been inactivated by gene-targeting. E14TG2a ES cells Origin: B6;129P2 Survival is normal. COX-2 deficiency results in small kidneys with lesions that cause a progressive deterioration with aging. Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid. Unknown Available. Taconic Stock 002181-M (homozygotes) Stock 002181-T (heterozygotes) Stock 002181-W (wild-type) For research purposes only. For breeding must have a Research Crossbreeding Agreement with Taconic. No distribution to third parties. Morham et al., 1995 hCOX2 Symbol: Cox2 Updated 5/30/06   1950-bp HindIII cDNA with humanCox2/RatNSE promoter C57BL/6J x C3H/J (B6C3)   Overexpress hCox2 in neurons. 2x increase brain prostaglandin. Kainic acid induced seizures increased in hCox-2 relative to wt. Giulio Maria Pasinetti giulio.pasinetti@mssm.edu Kelley et al., 1999 COX-2 Null   homologous recombination to disrupt the mouse gene encoding COX-2       Unpatented Morham et al., 1995 Iadecola al. Cox2 (line 303) The Jackson Lab Symbol: Cox2 Posted 6/17/10 C57BL/6J-Tg(Thy1-PTGS2)303Kand/J The human COX-2 ORF subcloned into the Thy-1 promoter. Origin: C57BL/6J; Generation: N6+ (07-Jun-10). Mice are viable and fertile. At 12 months deficit in spatial memory develops and at ~20 months a significant deterioration in non-spatial memory tasks develops. ~25-40-fold increase in PGE2 (Cox2) expression primarily to neurons of the amygdala, striatum, cerebral cortex, and hippocampus. The Jackson Lab, under development, stock #010703. Use by companies or for-profit entities requires a license prior to shipping. Andreasson et al., 2001 Cox2 (line 300) The Jackson Lab Symbol: Cox2 Posted 6/17/10 C57BL/6J-Tg(Thy1-PTGS2)300Kand/J The human COX-2 ORF subcloned into the Thy-1 promoter Origin: C57BL/6J; Generation: N6+ (07-Jun-10). Significant deficits in spatial and nonspatial memory, aversive behavior. ~10-12-fold increase in PGE2 (Cox2) expression directed primarily to neurons of the amygdala, striatum, cerebral cortex, and hippocampus. The Jackson Lab, under development, stock #010800. Use by companies or for-profit entities requires a license prior to shipping. Andreasson et al., 2001