Transgene: APP V717F PDAPP plus Swedish
Mutation: double mutations at KM670/671/NL (Swedish mutation), added to V717F (Indiana
Promoter: platelet-derived growth factor
Mouse Strain: C57BL/6 x DBA/2 F2
Young mice (2-4 mos) with both Indiana and Swedish mutations had almost twice as
much Aβ in their hippocampi, but much lower human APP levels.
No amyloid plaques were detected in the brains of 2- to 4-month-old mice, yet electrophysiological
recordings in hippocampal slice prepartions from these mice detected synaptic transmission
Hsia AY, Masliah E, McConlogue L, Yu G-Q, Tatsuno G, Hu K, Kholodenko D, Malenka
RC, Nicoll RA, Mucke L. Plaque-independent disruption of neural ciruits in Alzheimer's
disease mouse models. Proc Nat Acad Sci (USA). Mar 1999;96:3228-33.