General Information

Transgene: APP V717F PDAPP plus Swedish mutation

Mutation: double mutations at KM670/671/NL (Swedish mutation), added to V717F (Indiana mutation)

Promoter: platelet-derived growth factor

Mouse Strain: C57BL/6 x DBA/2 F2

Phenotype

Neuropathological Analysis:

Young mice (2-4 mos) with both Indiana and Swedish mutations had almost twice as much Aβ in their hippocampi, but much lower human APP levels.

No amyloid plaques were detected in the brains of 2- to 4-month-old mice, yet electrophysiological recordings in hippocampal slice prepartions from these mice detected synaptic transmission deficits.

Availability

Patents:

Reference

Hsia AY, Masliah E, McConlogue L, Yu G-Q, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L. Plaque-independent disruption of neural ciruits in Alzheimer's disease mouse models. Proc Nat Acad Sci (USA). Mar 1999;96:3228-33. Abstract