Updated 31 October 2010

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Name/ Symbol Strain Name Transgene/ Promoter and Regulatory Elements Genetic Background Behavioral  Phenotype Neurological  Characteristics Patents/  Availability Primary  Citation APP ki The Jackson Lab Symbol: ADF Posted 07/26/10 STOCK Apptm1Sud/J Insertion of a truncated exon 16 of the mouse Aβ (A4) APP/ Swedish mutant exon 16 and London/Dutch mutations of exon 17. Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl<+>; Backcross: C57BL/6; Generation: N?pN1. Homozygotes are viable and fertile. No overt phenotype has been observed. The Jackson Lab, cryopreserved, stock #008390. Sudhof, 2008 BRI-Aβ42 The Jackson Lab Symbol: APP695 Posted 07/26/10 B6.Cg-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J BRI-Aβ42 tg/mo prion PrP/ a cDNA seq. ITM2B/wt APP695/founder line 12e. Origin: C3B6F1 x B6; Backcrossed to C57BL/6J; Generation 5. Mice are viable and fertile with a normal lifespan and no obvious behavioral abnormalities. Three-month mice accumulate detergent-insoluble Aβ and plaques in the cerebellum. Extracellular Aβ plaques are present in the hippocampus at 12 months. The Jackson Lab, cryopreserved, stock #007182. McGowan et al., 2005 arcAβ Symbol: APP695 Posted 06/27/10   Swe (K670N + M671L) and Arc mutations (E693G)/pMoPrP-Xho. Origin: B6D2 F1; Background: hybrid C57BL/6 and DBA/2. Cognitively impaired from 6 months in MWM and Y-maze/active avoidance behavior. Aβ deposits at 6 months in cortex and hippocampus, no β-amyloid plaque. At 9-15 months, β amyloid plaques become prominent feature. Also severe CAA present. Contact Roger M. Nitsch, nitsch@bli.unizh.ch Knobloch et al., 2007 TgAPParc Symbol: APP Posted 06/08/10   HuAPP695 cDNA/ Arctic mutation (E693G)/ mouse Thy 1.2. Origin: C57BL/6-CBA; backcross C57BL/6 for 2 generations; current generation 5. Spatial learning and memory deficit at 15 months in Barnes maze. APParc levels ~threefold higher than endogenous; amyloid deposition in subiculum at seven months, spreading to thalamus at 18 months. Contact Caroline Graff: caroline.graff@ki.se Rönnbäck et al., 2009 APP695/EYFP Symbol: APP695 Posted 05/19/09 B6;C-Tg(Prnp-APP695*/EYFP)49Gsn/J Hu APP695 C-terminus tagged with enhanced yellow fluorescent protein (EYFP)/moPrnP. Origin: (BALB/c x C57BL/6)F1 Generation: F?+ (13-Mar-09). Mice are viable and have no observable abnormalities. EYFP expression in brain, spinal cord and sciatic nerve. Primary hippocampal cultures express EYFP at low levels. The Jackson Lab, under development, stock #008636. Use of mice by companies or for-profit entities requires a license prior to shipping.   BRI-Abeta42 Symbol: APP695 Posted 12/23/08 B6;C3-Tg(Prnp-ITM2B/APP695*42)A12Emcg/J Hu integral membrane protein 2B (ITM2B)/mo/hu APP695/MoPrP/ C3B6F1 x B6/line BRI-Aβ42A (12e). Origin: (C3H x C57BL/6)F1 X C57BL/6; Background: mixed B6C3; Generation: ?+N0 (28-Dec-07). Viable and fertile, normal lifespan, no obvious behavioral abnormalities. Hemizygous BRI-Aβ42 mice accumulate detergent-insoluble amyloid-β with age and develop cored plaques in the cerebellum at 3 months of age, later in the forebrain. The Jackson Lab, available, stock #007002. For research or non-commercial use only. McGowan et al., 2005 BRI-Abeta40 Symbol: APP695 Posted 12/23/08 B6.Cg-Tg(Prnp-ITM2B/APP695*40)1Emcg/J Hu integral membrane protein 2B (ITM2B) /mo/hu APP/MoPrP/ C3B6F1 x B6/line 1d. Origin: (C3H x C57BL/6)F1 X C57BL/6; Congenic, this is a C57BL/6J backcross of Stock No. 006880; Generation: N5F1 (18-Dec-08). Viable and fertile, normal lifespan, no obvious behavioral abnormalities. Mice expressing high levels of Aβ1-40 do not develop overt amyloid pathology or accumulate detergent-insoluble amyloid-β. The Jackson Lab, available, stock #007180. For research or non-commercial use only. McGowan et al., 2005 BRI-Abeta40 Symbol: APP695 Posted 12/23/08 B6;C3-Tg(Prnp-ITM2B/APP695*40)1Emcg/J Hu integral membrane protein 2B (ITM2B)/mo/hu APP695/MoPrP/ C3B6F1 x B6/line 1d. Origin: (C3H x C57BL/6)F1 X C57BL/6, Background: mixed B6C3, Generation: N1F2 (18-Dec-08). Viable and fertile, normal lifespan, no obvious behavioral abnormalities. Mice expressing high levels of Aβ1-40 do not develop overt amyloid pathology. The Jackson Lab, available, stock #006880. For research or non-commercial use only. McGowan et al., 2005 5X FAD Symbol: APP695/PSEN1 Posted 12/22/08 B6SJL-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/J First transgene huAPP695/Swe (K670N, M671L), Florida (I716V), and London (V717I); second transgene huPS1 (M146L and L286V) mutations/exon2 of mThy1/ C57/B6XSJL hybrid embryos. Origin: (C57BL/6 x SJL)F1, Generation: ?+N11N3 (04-Nov-08). Hemizygous mice are viable and fertile. Aβ42 accumulation (1.5 months), amyloid deposition and gliosis (2 months), synapse degeneration (4 months), increased p25 levels (9-12 months), neuron loss, and spatial learning deficit (4-5 months). The Jackson Lab, available, stock #006554. For research or non-commercial use only. Oakley et al., 2006 Tg(Prnp-App/APPswe)E1-2Dbo Symbol: APP Posted 12/18/08 B6.Cg-Tg(Prnp-App/APPswe)E1-2Dbo/J Chimeric mo/huAPP(APPswe) /mo prnp/founder line E1-2. Origin (C57BL/6J x C3H/HeJ)F2, Backcross C57BL/6J, Generation: N14?N5 (20-Dec-07). Congenic mice, 12-13-month-old performed cognitive tasks similar to non-transgenics. Express APP(Swe) at levels ~threefold higher than endogenous moAPP. Aβ1-42 in brain increases with aging from low levels at 6-14 months of age to relatively high levels at 24-26 months, when deposits of Aβ start to form. The Jackson Lab, available, stock #006005. For research or non-commercial use only. Borchelt et al., 1996; Savonenko et al., 2003 Tg(Prnp-APP)A-2Dbo Symbol: APP Posted 12/18/08 B6.Cg-Tg(Prnp-APP)A-2Dbo/J HuAPP/moPrnp/C57BL/6J egg/ founder line A-2. Origin: C57BL/6J, Breeding: cross hemizygous male x C57BL/6J female. Hemizygous mice are viable and fertile. No abnormal phenotype detected. The Jackson Lab, cryopreserved, stock #006006. For research and non-commercial use only. N/A Tg-SwDI/B Symbol: APP/Swe/Dutch/Iowa Posted 12/16/08 C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/J 2.1-kb transgene construct hu AβPP770, with Swedish K670N/M671L, Dutch/Iowa E693Q/D694N mutations/Thy1.2 promoter/C57BL/6. Background C57Bl/6, Generation: F?+ (22-Jul-08). Mice homozygous for the transgenic insert are viable and fertile. Learning and memory deficit by 3 months. Plaques in hippocampus and cortex by 3 months; amyloid-β deposits throughout forebrain by 12 months. The Jackson Lab, available, stock #007027. For research or non-commercial use only. Davis et al., 2004 APPDutch Symbol: APP Posted 11/14/08 C57BL/6J-Tg(Thy1-APPDutch) huAPP751 with E693Q mutation/Thy1.2 C57BL/6J N/A Develop cerebral amyloid angiopathy (in the absence of parenchymal amyloid) at approx. 2 yrs., Aβ40>>Aβ42. Contact Mathias Jucker, mathias.jucker@uni-tuebingen.de Herzig et al., 2004 APPArcSwe Symbol: APP Posted 02/19/08 C57BL/6J-CBA-F1 Human APP cDNA clone with artic mutation (E693G) and Swedish mutation (KM670/671N)/modified Kozak seq/murine Thy-1 promoter. Origin: C57BL/6J-CBA; Background: C57Bl/6J; Backcross five generations. Spatial learning deficits at 4-8 months of age in MWM. Inclusion of the Artic mutation results in enhanced accumulation of soluble Aβ aggregates, facilitated accumulation of Aβ inside neurons and more robust senile plaques. PCT WO2005/089539; Assignee BioArctic Neuroscience. Non-commercial use: Contact Lars Nilsson, lars.nilsson@pubcare.uu.se Phone: +46 18 471 5039. fax: +46 18 471 4808 Uppsala University, Sweden Lord et al., 2006 APPPS1 Symbol: APP Posted 05/06/07 B6-Tg(Thy1-APPswe; Thy1-PS1 L166P) Pronuclei coninjected with Thy1-APPKM670/671NL and Thy1-PS1L166P constructs, integration site on the lower arm of chr 2 between 40 and 60 cM C57BL/6J Cognitive deficits in a 4-arm spatial maze task at 8 months of age. APPPS1 develops cerebral amyloidosis at 6-8 weeks, Aβ 42 >> Aβ 40. Contact Mathias Jucker, mathias.jucker@uni-tuebingen.de Radde et al., 2006 TetO-APPSwe/Ind (line 885) Symbol: APP Updated 12/09/08 B6C3-Tg(tetO-APPswe/ind)8-85Dbo/J Chimeric mo/hu APP695(Swe/Ind) x tetO/ C57BL/6J X C3HeJ F2. Origin founder line 8-85, male hemizygous x female B6C3F1/J. Generation: [?+N1p]+N4 (11-Nov-08) Hemizygous mice viable/fertile. Bigenic mice have 10-fold more activity. Activity abolished by rearing with doxycycline. Mo/huAPP protein at 10-30-fold over endogenous. Treatment with doxycycline inhibits APP expression by >95% and reduces Aβ production. Plaques at 6 months. The Jackson Lab, available, stock #006004. For research or non-commercial use only; tet-system licence may be required. Jankowsky et al., 2005 Tg(TetO-APPSwe/Ind)102Dbo Symbol: APP Posted 12/18/08 B6.Cg-Tg(tetO-APPswe/ind)102Dbo/J Chimeric mo/hu APP695(Swe/Ind)/tetO/ C57BL/6J X C3H/HeJ F1. Origin (C57BL/6J x C3H/HeJ)F1, Background: founder line 102 bred to tgCamk2a-tTA mice on a B6;CBA mix, Congenic, Generation: N11+ (10-Dec-07). Hemizygous mice viable/fertile. Mo/huAPP protein at 10-30-fold over endogenous APP levels. Line 102 has the greatest sensitivity to doxycycline. The Jackson Lab, available, stock #007051. For research or non-commercial use only; tet-system license may be required. Jankowsky et al., 2005 Tg(TetO-APPSwe/Ind)107Dbo Symbol: APP Posted 12/18/08 B6.Cg-Tg(tetO-APPswe/ind)107Dbo/J Chimeric mo/hu APP695(Swe/Ind)/tetO/ C57BL/6J X C3H/HeJ F1. Origin (C57BL/6J x C3H/HeJ)F1, Background: founder line 107 bred to tgCamk2a-tTA mice on a B6;CBA mix, Congenic, Generation: ?+ F0 (20-Dec-07). Hemizygous mice viable/fertile. Mo/huAPP protein at 10-30-fold over endogenous APP levels. Line 107 has intermediate sensitivity to doxycycline. The Jackson Lab, available, stock #007052. For research or non-commercial use only; tet-system license may be required. Jankowsky et al., 2005 TetO-APPSwe/Ind (line 885) Symbol: APP Posted 12/09/08 B6.Cg-Tg(tetO-APPswe/ind)885Dbo/J Chimeric mo/hu APP695(Swe/Ind) x tetO/ C57BL/6J X C3HeJ F2. Origin founder line 8-85, male hemizygous x female B6C3F1/J. Congenic, Generation: N11+F2 (12-May-08). Hemizygous mice viable/fertile. Bigenic mice have 10-fold more activity. Activity abolished by rearing with doxycycline. MMo/huAPP protein at 10-30-fold over endogenous. Treatment with doxycycline inhibits APP expression by >95% and reduces A? production. Plaques at 6 months. The Jackson Lab, available, stock #007049. For research or non-commercial use only; tet-system license may be required. Jankowsky et al., 2005 Amyloid β (A4) precursor protein-binding, family B, member 1 (Apbb 1) Symbol: P97FE65 Updated 01/05/09 B6.129-Apbb1tm1Quhu/J 500bp frag with first 3 start codons in exon 2 replaced by PKG promoter neo-cassette/R1 ES cells/C57BL/6. Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl<+>; backcross C57BL/6J Gen >10. Viable and normal, no physical abnormalities. Null mice have slower learning rates in aversive/spatial memory tasks. p97 protein not expressed in null mice, p60 N-term truncated isoform four- to fivefold greater levels. The Jackson Lab, cryopreserved, stock #005708. Companies or for-profit entities require a license prior to shipping. Wang et al., 2004 APPSWE (2576) Symbol: APP Updated 10/31/10 B6;SJL-Tg(APPSWE)2576Kha Human AP695 cDNA with KM670/671NL/ hamster prion protein gene promoter C57BL/6. Currently breeding hemizygous males with B6SJLF1 females Memory deficits seen in 9-10 month old tg mice. Numerous Aβ plaques, oxidative lipid and glycoxidative damages  Patent: 5,877,399 Taconic Datasheet. Stock #001349. For research purposes only. For breeding must have a Research Crossbreeding Agreement with Taconic. No distribution to third parties. Hsiao et al., 1996 APPSWE (2576) on 129S6 background Symbol: APPSWE (2576) Posted 10/31/10 129S6.Cg-Tg(APPSWE)2576Kha N20+? Human APP695 cDNA with KM670/671NL/hamster prion protein gene promoter. Founder Line 2576. Backcrossed: 129S6, Generation N16. Maintained by backcrossing hemizygous male with 129S6/SvEvTac female. Memory deficits seen in 9-10 month old tg mice. Numerous Aβ plaques, oxidative lipid and glycoxidative damages. This background does not carry the Pde6b rd1 retinal degeneration mutation, but does carry a mutated Disc1 gene. Taconic Datasheet. Stock #002789. For research purposes only. For breeding must have a Research Crossbreeding Agreement with Taconic. No distribution to third parties. Hsaio et al., 1996 Human BACE Symbol: BACE Posted 6/13/2005   Human wtBACE-1 cDNA /mouse Thy 1/microinjected DBA/C57BL/6 embryos. Origin: FVB. Background C57BL/J   Transgene expressed in neurons only. Line 16 had high expression of human BACE. Frozen embryos stored at Charles River Breeding Labs. Contact: Michael Willem Willem et al., 2004 APPSw Symbol: APP Posted 6/7/2005 Tg.AD147.71H Human APPK670N, M671L (Swedish), mThy1.2. Origin: C57BL/6, DBA/2. Backcrossed C57BL/6 for 3N, then intercrossed F13.   Amyloidosis in the 2nd year of life, Amyloidosis 4X more prominent in females than males. Congophilic plaques in cortex and hippocampus, brain Aβ42 levels are 10 fold lower than Aβ40 levels. Contact: Laurence Ozmen Laurence.ozmen@roche.com Richards et al., 2003 hAPPSw/Ind/Arctic Symbol: APP Posted 4/21/2005   Arctic (E22G), Swedish, and Indiana mutations human APP/PDGFß promoter Origin: C57BL/6Hsd; Background C57BL/6J; Generation Arc6 - N5 and Arc48 - N3 Pending Arctic mice form amyloid plaques faster and more extensively than J20 mice, even though they had lower Aβ 1-42/1-40 ratios. Relative levels of hAPP and of the β-secretase-generated C99 fragment were lower in Arc6 and higher in Arc48 than in J20 mice. Contact Lennart Mucke Lmucke@gladstone.ucsf.edu Cheng et al., 2004 APPSw-NSE Symbol: APP Posted 2/5/2005   CMVAPP695sw construct, containing APPsw695/rat pNSE-CAT promoter / NSE-APPsw with the prokaryotic sequence eliminated. Origin: C57BL/6 x DBA/2, Background C57BL/6, Backcross 5 generations At 12 months showed longer escape latencies and increased escape distances in water maze. At 12 months increased Aβ-42 staining without plaque formation. Tau phosphorylation enhanced, JNK and p38 activated. Cox-2 levels, Caspase-3 and TUNEL staining seen. Patent filing date: 11/4/02 Contact: Yong K Kim kimyongkyu@hanmail.net Hwang et al., 2004 APP695K612V or SβCK612V Symbol: APP Posted 12/18/2004   Valine substituted for lysine at site of βAPP/cytomegalovirus enhancer and chicken β-actin promoter. OE C99 Origin: C57BL/6 x C3H. Backcrossed to C57BL/6 Generation 4 (1998)   No brain lesions or plaque formation. 9-13 month old mice show 5x expression of protein product in muscle. Dr. Lee-Way Jin. These mice are no longer available Jin et al., 1998 Down syndrome model; segmental trisomy 16 Symbol: Ts(1716)65Dn Updated 3/16/09 B6EiC3Sn a/A-Ts(1716)65Dn 3 copies of mouse APP/Translocation of distal end of mouse Chr 16 to Chr 17. Origin: DBA/2J; Generation: N?+N6 (08-Oct-08). Mice live until adult age. Low birth weight, developmental delay, muscle trembling, male sterility, reduced learning. APP elevated in cerebral cortex. At 6 months, higher level of Aß in hippocampus and mice show decline in cholinergic phenotype and cognitive deterioration. The Jackson Lab, Stock #001924. For recipient’s research only, not to be sold to third parties for breeding or any other use. Davisson et al., 1990 APP-C99 (tg13592) Symbol:APP Posted 10/2/04   5 copies C99 of b-APP /cytomegalovirus enhancer/b-actin promoter /C57BL/6 x DBA/2 Crossed to C57BL/6J >10 Generations Mice exhibit hypoactivity and spatial learning deficit. From 6-12 months display Aβ-immunoreactive deposits within the skeletal muscle fibers. Availability: Contact Dr. Ken-ichiro Fukuchi Fukuchi et al., 1996 APPV642IKI Symbol:APP Posted 8/10/04   APPV642I/ 'knock-in' technique of homologous recombination and Cre-loxP system/Clone R34C(30)-9. Origin: C57BL/6 x CBA and CD-1 Significant deterioration of long-term memory. Acquisition of spatial memory slightly affected, but no deterioration in short-term working memory. 2yr old mice show no neuritic plaques or neurofibrillary tangles, but increases in amount of β-amyloid Aβ42 (43) compared to Aβ40. US Patent Application No.60/482,021 and PCT/JP2004/002296 Availability: Contact Dr Masaaki Matsuoka Kawasumi et al., 2004 A-R1.40 Symbol:APP Posted 12/09/08 A.129(B6)-Tg(APPSw)40Btla/J YAC with 300 kb hAPPSwe gene/R1 ES cells. Origin: (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then to DBA/2J, N7. Background A/J, Generation: N21+N1 (20-DEC-07) N/A Exhibits levels of amyloid beta comparable to the B6-R1.40 strain, but with later onset. The Jackson Lab, available, stock #006555. For research or non-commercial use only. Lehman et al., 2003 B6-R1.40 Symbol:APP Updated 12/09/08 B6.129-Tg(APPSw)40Btla/J YAC with 300 kb hAPPSwe gene/R1 ES cells Origin: (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then to DBA/2J, N7. Background C57BL/6J, N22+F2 (08-DEC-07) N/A Highest-level Aβ40/42 compared to D2-R1.40 and 129S1-R1.40 mice. Aβ deposits in frontal and parietal cortex of >1-year-old mice The Jackson Lab, available, stock #005300. For research or non-commercial use only. Lamb et al., 1997 B6-Py8.9 Symbol:APP Updated 12/09/08 B6.129S2-Tg(APP)8.9Btla/J 650 kb YAC with hAPP and 350 kb flanking region Origin: 129S2/SvPas-derived D3 ES cells Background C57BL/6J, Generation: N11+N1F2 (20-DEC-07) N/A Mice express hAPP transcripts and proteins at levels similar to endogenous mouse. No evidence of AD-type pathology The Jackson Lab, available, stock #005301. For research or non-commercial use only. Lamb et al., l993 D2-R1.40 Symbol:APP Updated 12/09/08 D2.129(B6)-Tg(APPSw)40Btla/J 650-kb YAC with 400-kb huAPP + Swiss mutation/R1 ES cells Origin: 129X1/SvJ x 129S1/Sv-+P+Tyr-cKitlS1-J/+ Background DBA/2J, Generation N28 (08-JAN-08) N/A Lowest level of Aβ40 and Aβ42 compared to B6-R1 The Jackson Lab, available, stock #006472. For research or non-commercial use only. Lehman et al., 2003 129S1-R1.40 Symbol:APP Updated 12/08/08 129S1.Cg-Tg (APPSw)40Btla/J YAC with 300 kb hAPPSwe gene/R1 ES cells Origin: (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then to DBA/2J, N7. Background 129S1/SvImJ, N24. N/A Lower amts of APP CTFs, intermediate levels of Aβ40 and Aβ42 and equivalent levels of holo-APP compared to D2- and B6-R1.4 mice. The Jackson Lab, available, stock #006409. For research or non-commercial use only. Lehman et al., 2003. 129S1-R1.40 Symbol:APP Posted 12/08/08 129S1.129(Cg)-Tg (APPSw)40Btla/2J YAC transgene with 300 wt hAPPgene/K670N/M671L(Swe)/R1 ES cells. Origin: (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then to DBA/2J, N7. Background: 129S1/SvImJ, N24. N/A Higher transgene copy number than Stock # 006409. Transgene expression (mRNA and full-length protein) is two- to threefold the wt mouse App expression level. Lower amts of APP CTFs, intermediate levels of Aβ40 and Aβ42 and equivalent levels of holo-APP compared to D2- and B6-R1.4 mice. The Jackson Lab, under development, stock #008609. For research or non-commercial use only. Lehman et al., 2003. Amyloid β(A4) precursor-like protein 2 Symbol: Aplp2 Updated 01/05/09 B6.129S7-Aplp2tm1Dbo/J Inactivated Aplp2 gene by deleting 1.1kb segment/PGKneo cassette/AB2.1 ES cells. Origin: B6;129S7; Backcross C57BL/6J for 5 generations (7/01). No behavioral abnormalities. No Aplp2 gene product (mRNA or protein) is detected. The Jackson Lab, cryopreserved, stock #004142. For research or non-commercial use only. von Koch et al., 1997 APPnull: Amyloid-β (A4) precursor protein Symbol: APP Updated 12/18/08 B6.129S7-Apptm1Dbo/J Inactivated Mouse APP gene/ PGKneo targeting vector/AB2.1 ES cells. Origin B6;129S7. Backcross C57BL/6J. Generation: N10+N7F8 (04-Dec-07). Homozygous mice are viable, no physical or behavioral abnormalities at birth. By 14 weeks decreased locomotor activity. At birth no App gene product detected,14 weeks the mice exhibit evidence of reactive gliosis. Available The Jackson Lab, available, stock #004133. For research or non-commercial use only. Zheng et al., 1995 APP -C100   Human APP695 cDNA Carboxy terminal 100 a.a./ dystrophin neural promoter C58BL/6 x SJL  homozygous Tg showed significant deficits in cued, spatial and reversal performance.  age-dependent impairment of spatial learning. age-dependent neuronal and synaptic degeneration, irregular cytoplasmic accumulations of atypical secondary lysosomes, and an increased neurofilament concentration in unmyelinated axons 5,672,805, 5,849,999, 5,894,078 Contact Rachael Neve These mice are no longer available. Neve RL et al., 1996 APP Flemish/ APPDutch   Human APP770 cDNA with A682G/ Human APP770 cDNA with E693Q/ mouse thy-1 gene promoter FVB/N differential glutamatergic responses, increased aggression, occasional spontaneous seizures and variable premature death significantly decrease α-secretase APP while increasing β-secretase cleaved C-terminal fragments. Aβ level remains low without formation of amyloid plaque. Unpatented Contact Paul Van Dun These mice are no longer available. Kumar-Singh et al., 2000 B6-J1-96 Symbol: APPSwLon Updated 12/16/08 B6.129S4-Tg(APPSwLon)96Btla/J YAC with 300 kb hAPPSwe/London gene/J1 ES cells/founder line J1.96 Origin: 129S4/SvJae; Background C57BL/6J, Generation: N12+F2 (30-Apr-08) N/A High levels of Aβ peptides in tg with Swe and London mutations. Aβ total and 42/43 are elevated in tg with London mutation. The Jackson Lab, available, stock #006406. For research or non-commercial use only. Lamb et al., 1997 APP London V717I Updated 5/27/05   Human APP695 cDNA with V717I/ mouse thy-1 gene. The thymus specific regulatory elements in intron 3 are thereby deleted, making the resulting promoter "neuron-specific" FVB/N decreased exploration, increased neophobicity, increased male aggressivity amyloid plaques and cerebrovascular angiopathy - onset 10-12 months, cholinergic fiber distortion Unpatented Contact Paul Van Dun Moechars D et al., 1999 NORBA   signal peptide and 99 residues of CTF of bAPP under control of cytomegalovirum enhancer/chicken b-actin promoter. 2000 copies of bA-NOR b were microinjected into one pronucleus of fertilized B6C3F1 x C57BL/6N hybrid eggs N/A Aβ was detected biochemically in brain, kidney, and pancreas with the largest amount present in Pancreas. over 30 times Aβ accumulation in transgenic plasma than in normal human plasma. Contact Mikio Shoji Kawarabayashi et al., 1996 PDGF-APPWT (See JAX datasheet) Symbol:App Updated 3/16/09 B6.Cg-Tg(PDGFB-APP)5Lm/J APPInd tg sequence converted to wildtype by PCR primer modification/PDGFB promoter/(v-sis) oncogene homolog. Origin:C57BL/6 X DBA/2 F2. Backcross C57BL/6J. Maintained as hemizygote. Generation N11+13 (24-Dec-08).   Transgene expression in cerebral neurons, neocortex and hippocampus, with total Aβ levels and 42 Aβ levels lower than in the APP SwInd mutant line. No amyloid plaques up to 24 months of age. Available The Jackson Lab Stock# 004662. Strain serves as control for Stock # 006293. For nonprofit entities only. Mucke et al., 2000 PDAPP SwInd(J20) Symbol:App Updated 12/2/08 B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2J Tg construct: hAPPSwInd Promotor: PDGFB Injected: C57BL/6 x DBA/2F2 embryos C57BL/6 X DBA/2 F1 mice. Generation: N12+3 (03-JUN-07) WM spatial memory retention, acquisition, deficits 6-7 months (Palop et al., 2003) Total Aβ, and Aβ42 in neocortical and hippocampus High levels of Aβ(1-42) resulted in age-dependent formation of Aβ plaques in mutant hAPP mice but not wild-type hAPP mice Available The Jackson Lab Stock# 004661 extinct; replaced by Stock# 006293. See TJL datasheet. Mucke et al., 2000 PDGF -APPSwInd line J9 Updated 7/7/04   The Swedish mutation was introduced into the PDGF-APPInd transgene. PDGF-APPSw, Ind transgene injected into (C57BL/6 × DBA/2) F2 one-cell embryos. C57BL/6 x DBA/2 F2 N/A 2-4 month old tg mice had almost twice as much A in their hippocampi, but much lower human APP levels than APPInd (line H6) tg mice. No amyloid plaques were detected yet electrophysiological recordings in hippocampal slice preparations detected synaptic transmission deficits.   Hsia et al., 1999 APP695 Line C3-3 Symbol: App695 Updated 12/30/08 C3B6-Tg(APP695)3Dbo/J B6C3H pronuclei were injected with cDNA encoding a chimeric APP695, with human gene Swedish mutations K595N, M596L, regulated by mouse prion promoter. Origin: (C57BL/6J x C3H/HeJ)F2. Congenic mice with APPswe develop memory deficits Mice expressing this transgene develop amyloid deposits in brain tissue by 18-20 months of age. Cryopreserved The Jackson Lab Stock#: 003375 Borchelt et al., 1996 APP/RK    Alpha Secretion cDNA with K687E, R684D/ mouse thy-1 gene promoter FVB/N neophobic reaction, progressive CNS disorganization, premature death no change in NMDA receptor density or distribution. None of the typical hallmark of AD (Amyloid deposits, neurofibrillary tangles) Unpatented Contact Paul Van Dun. These mice are no longer available. Moechars D et al., 1996  TgAPPSwe-KI   humanized Aβ and introduced the K670N/M671L FAD mutation into a single transgenic line, exon 16. Outbred CD-1 N/A 9 fold greater than in normal human brain and nonamyloidogenic processing is depressed. Spatial and temporal expression patterns of human Aβ are reproduced. Contact: Dorothy Flood or Steve Trusko Reaume et al., 1996 APP751Swedish (APP14) Symbol: APP Updated 1/12/04   APP751 Swedish /Human Thy-1 Origin: C57B6J No abnormal behavior reported 2 fold overexpression of APP mRNA. No indication of AD pathology up to an age of 2 years. Unpatented Contacts: Matthias Staufenbiel Andrä et al., 1996 APP Swe/London (APP22) Symbol: APP Updated 1/12/04   APP Swe/London/Human Thy-1 promoter Origin:C57B/6J   2x over expression of APP mRNA. Diffuse Aβ deposits detected in neocortex and hippocampus at 18 months. Exhibit Neuritic changes, dystrophic cholinergic fibers and hyperphosphorylated tau. Unpatented Contact: Matthias Staufenbiel Sturchler-Pierrat et al., 1997 APP751 Swedish (APP23) Symbol: APP Updated 1o/30/05   APP751Swedish/ murine Thy-1.2 Origin: C57BL/6J Learning impairment in Morris water maze and a passive avoidance paradigm. 7x over expression of APP mRNA. A deposits at 6 months, by 24 months in neocortex and hippocampus. Inflammation, neuritic and synaptic degeneration and tau hyperphosphorylation. Evidence for Cerebral amyloid angiopathy (CAA). Unpatented Contact: Matthias Staufenbiel Sturchler-Pierrat et al., 1997 TgCRND8 Updated 10/30/05   APPSwe/Ind (KM670/671NL+V717F)/ hamster prior promoter Hybrid C3H/He-C57BL/6 At 3 months impairment in acquisition and learning reversal in memory version of the Morris water maze. Immunization against Aβ42 offset learning impairment (Janus). Aβ deposits at 3 months of age, by 10 weeks levels of Aβ40 and Aβ42 peptides 5-fold higher than endogenous Mo-APP. Dense-cored plaques and neuritic pathology evident from 5 months of age. Activated microglia appear concurrently with plaques. Contact: David Westway Chishti, MA et al., 2001 PDAPP(Line109) Symbol:APP Updated 10/30/05   Minigene encoding codon717Valine to Phenylalanine mutation/modified hAPP introns 6,7,8 in construct resulted in expression of 770, 751 and 695 isoforms of human APP/PDGF-β promoter. SwissWebster x B6D2F1 (C57Bl/6 x DBA/2) Significant impairment on a variety of different learningand memory tests Aβ deposits, neuritic plaques, synaptic loss, astrocytosis and microgliosis 5,811,633,  5,877,015, Contact: Dora Games or Dale Schenk Games et al., 1995; Rockenstein et al., 1995 BACE2delta6 Symbol: BACE2 Posted 12/30/08 B6;129P2-Bace2tm1Bdes/J, Breeding: bred as homozygotes Targeting vector (loxP site/hygromycin resistance gene flanked by FRT sites) introduced into intron 5/2nd loxP site inserted within intron 6/electroproated into 129P2/OlaHsd derived E14 (ES) cells/C57BL/6J blastocysts. Chimeric animals crossed to mice expressing Cre recombinase with the phosphoglycerate kinase promoter to delete exon 6. Origin: 129P2/OlaHsd. Homozygous mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Proteins generated from the targeted locus lack beta-secretase activity. The Jackson Lab, cryopreserved, stock #005618. Companies or for-profit entities require a license prior to shipping. License Requirements for Strains using Cre-lox Technology only apply in Canada. Dominguez et al., 2005 hBACE Symbol: APP Posted 3/6/2005   hBACE / MoPrP.Xho /a 15.9-kb NotI linear fragment Origin and background C57B6/C3H. Maintained as homozygous N/A BACE L, M and H express 7, 10 and 20-fold BACE over endogenous levels, respectively. No evidence of Aß deposition. Increased BACE expression in neuronal cell bodies, axons and synaptic elements of the hippocampus, puncta within the granule cell layer of the cerebellum, and neuropil within the spinal cord. Contact: Virginia M-Y Lee vmylee@mail.med.upenn.edu Lee et al., 2005 hBACE54 Symbol: BACE Posted 8/10/04   hBACE cDNA inserted into Xho1 of vector pTSCa1/murine Thy-1 promoter Origin: C57BL/6J; backcross >10 gen No major changes. Detailed analysis not yet performed hBACE mRNA ~ 4x higher than endogenous mRNA. Consistant hBACE protein expression in BACE54/4 line but variation in the Bace54/11 line. Highest protein in the cortex and hippocampus and lowest in the cerebellum. Contact Paolo Paganetti Bodendorf et al., 2002 Bace1 -/- (See JAX datasheet) Symbol: BACE Updated 12/30/08 B6.129-Bacetm1Pcw/J Disrupted 2-kb of BACE 1 containing exon 1 (residues 1-87)/replaced with a neomycin-resistance gene/transfected into R1 ES cells/C57BL/6J blastocysts. Origin: C57BL/6 mice; Backcross N7F?+N1F7 (05-Dec-07). Viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No gene product detected in brain tissue. Primary cultures of cortical neurons do not secrete amyloid-β peptides (Aβ1-40/42 or Aβ11-40/42) or beta C-terminal fragments (CTFs). The Jackson Lab, available, stock #004714. For research or non-commercial use only. Cai et al., 2001 BACE1 Null     Normal Healthy, fertile and appear normal in gross anatomy, tissue histology.   Unpatented Luo Y et al