General Information

Phenotype

Behavior:

Healthy, fertile and appear normal in gross anatomy, tissue histology.

Availability

Licensing/academic distribution contact information:

Patents: None

Reference

Primary:

Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, Vassar R. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 2001 Mar;4(3):231-2. Abstract.

Secondary:

Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC. BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 2001 Mar;4(3):233-4. Abstract.