Updated 5 November 2008

General Information

Transgene: Thy1-APPKM670/671NL and Thy1-PS1L166P constructs were coinjected into male pronuclei of C57BL6J oocytes, integration site on the lower arm of chr 2 between 40 and 60 cM. Generated on a pure C57BL/6J background.

Mutation: coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated presenilin 1

Promoter: neuron specific Thy 1

Mouse Strain: B6-Tg(Thy1-APPswe; Thy1-PS1 L166P)

Phenotype

Neuropathological Analysis:

APPPS1 develops cerebral amyloidosis at 6-8 weeks, Aβ 42 >> Aβ 40

Behavioral Phenotype:

Cognitive deficits in a 4-arm spatial maze task at 8 months of age

Availability

Contact Dr. Mathias Jucker, University of Tuebingen, mathias.jucker@uni-tuebingen.de

Reference

Primary:

Radde R, Bolmont T, Käser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, Jucker M (2006) Ab42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO reports 7: 940-946. Abstract