Posted 15 December 2003

General Information

Transgene: YAC containing entire wt 300 kb human APP gene introduced into R1 embryonic ES cells

Mutation: None

Mouse Strain: Original background 129S2/svPas;
Published/distributed Background C57BL/6J;
Generation: N22

Phenotype

Neuropathological Analysis:

Mice express hAPP transcripts and proteins at levels similar to endogenous mouse APP products in brain, neurons of hippocampus and neocortex and peripheral tissues. Mice did not show evidence of AD-type pathology.

Behavioral:

N/A

Availability

Bruce Lamb
Departments of Genetics and Neurosciences, Case Western Reserve University
10900 Euclid Avenue, Cleveland, OH 44106-4955, USA
Phone: (216) 368-2979
Fax: (216) 368-3432
Email: btl@po.cwru.edu

Patents: None

Reference

Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nat Genet. 1993 Sep;5(1):22-30. Abstract