Updated 9 December 2008

General Information

Transgene: YAC containing entire wt 300 kb human APP gene introduced into R1 embryonic ES cells

Mutation: None

Mouse Strain: Original background 129S2/svPas-derived D3 ES cells;
Published/distributed Background C57BL/6J;
Generation: N11+N1F2 (20-DEC-07).

Phenotype

Neuropathological Analysis:

Mice express hAPP transcripts and proteins at levels similar to endogenous mouse APP products in brain, neurons of hippocampus and neocortex and peripheral tissues. Mice did not show evidence of AD-type pathology.

Behavioral:

N/A

Availability

The Jackson Lab, available, stock #005301. For research or non-commercial use only.

Patents: None

References

Primary:

Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nat Genet. 1993 Sep;5(1):22-30. Abstract

Associated:

Alpar A, Ueberham U, Bruckner MK, Arendt T, Gartner U. 2006. The expression of wild-type human amyloid precursor protein affects the dendritic phenotype of neocortical pyramidal neurons in transgenic mice. Int J Dev Neurosci 24(2-3):133-40. Abstract

Alpar A, Ueberham U, Seeger G, Arendt T, Gartner U. 2007. Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network. Neuroreport 18(12):1247-50. Abstract