Posted 12 January 2004
Transgene: Mouse pronuclei (B6D2F1) were injected with a transgenic construct containing
cDNA-encoding hAPP751 with Swedish double mutation (at 670/671 position) plus London
mutationV717I (replaces a 600bp BglII-Spel fragment), regulated by the human Thy-1
Promoter: Human Thy-1 promotor
Mouse Strain: Origin: C57B/6
2 fold overexpression of APP mRNA. APP22 mice show inflammatory and massive glial
response. Aβ deposits, a diffuse type, are detected in neocortex and hippocampus
of 18 month old mice, but not in 12 month old. APP22 mice show neuritic changes,
dystrophic cholinergic fibers and hyperphosphorylated tau.
No abnormal behavioral changes reported in APP14 mice.
Novartis Pharma, Inc.,
S-386.809, CH-4002 Basel, Switzerland
Email: Matthias Staufenbiel
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S,
Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst
A, Staufenbiel M, Sommer B. Two amyloid precursor protein transgenic mouse models
with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13287-92.