General Information

Posted 12 January 2004

Transgene: Mouse pronuclei (B6D2F1) were injected with a transgenic construct containing cDNA-encoding hAPP751 with Swedish double mutation (at 670/671 position), regulated by the human Thy-1 promoter.

Promoter: Human Thy-1

Mouse Strain: Origin: C57B/6

Phenotype

Neuropathological Analysis:

2 fold overexpression of APP mRNA. APP14 mice do not show any indication of AD pathology up to an age of 2 years.

Behavioral:

No abnormal behavioral changes reported in APP14 mice.

Availability

Contact:
Matthias Staufenbiel
Novartis Pharma, Inc.,
CH-4002 Basel, Switzerland
Email: Matthias Staufenbiel

Patents: None

References

Primary:

Andrä, K., Abramowski, D., Duke, M., Probst, A., Wiederhold, K.-H., Bürki, K., Goedert, M., Sommer, B. & Staufenbiel, M. Expression of APP in transgenic mice: a comparison of neuron-specific promoters. 1996 Neurobiol. Aging 17, 183-190. Abstract

Associated:

Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13287-92. Abstract.