Updated 5 January 2009

General Information

Transgene: A 1.1-kb segment encoding the APLP2 promoter, first exon, and initial sequence of the first intron were replaced with PGKneo by homologous recombination. AB2.1 ES cells.

Mutation: Targeted mutation

Mouse strain: B6.129S7-Aplp2^tm1Dbo /J

Phenotype

Neuropathological Analysis:

At postnatal day 0, neuromuscular synapses appear normal in APLP2 knockout mice. Cognition not impaired. No Aplp2 gene product mRNA or protein detected.

Behavioral

No behavioral abnormalities. Viable and fertile. React similarly to controls in forelimb grip strength, balance, postural-, spinal-, and nociceptive reflexes. Cognition not impaired, in MWM and conditional avoidance tasks.

Availability

The Jackson Lab, cryopreserved, stock #004142. For research or non-commercial use only.

References

Primary:

von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS. Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice, Neurobiol. Aging 18 (1997), pp. 661-669. Abstract

Associated:

Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2. J. Neurosci.2005; 25: 1219-1225. Yang G, Gong YD, Gong K, Jiang WL, Kwon E, Wang P, Zheng H, Zhang XF, Gan WB, Zhao NM. Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2. Neurosci Lett. 2005 Aug 12-19;384(1-2):66-71.

Yang G, Gong YD, Gong K, Jiang WL, Kwon E, Wang P, Zheng H, Zhang XF, Gan WB, Zhao NM. Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2. Neurosci Lett. 2005 Aug 12-19;384(1-2):66-71.