General Information

Posted 8 June 2010

Transgene: Human APP695 cDNA with the Arctic mutation (E693G).

Mutation: APP(E693G)

Promoter: Mouse Thy1.2

Mouse Strain: C57BL/6-CBA. Backcrossed to C57BL/6 for two generations to establish heterozygous offspring B6CBA-Tg(Thy1.2-hAPParc). Backcrossed to C57BL/6 for five generations. Heterozygous mice are viable and fertile.

Phenotype

Neuropathological Analysis:

Express APParc at levels ~threefold higher than endogenous APP. Age-dependent progression of amyloid deposition, starting in the subiculum at 7 months and spreading to the thalamus at 18 months. Neuropathology is more severe in female mice.

Behavioral:

Spatial learning and memory deficit in the Barnes maze test in female mice at 15 months.

Availability

Contact:
Caroline Graff
Karolinska Institutet, Dept. Neurobiology, Care Sciences and Society Karolinska Institutet Dainippon Sumitomo Pharma Alzheimer Ctr. (KASPAC)
Novum level 5, Huddinge SE-141 57, Sweden
Phone: +46 8 585 836 19
Fax: +46 8 585 836 10
E-mail: caroline.graff@ki.se

Patents: None

References

Primary:

Rönnbäck A, Zhu S, Dillner K, Aoki M, Lilius L, Näslund J, Winblad B, Graff C. Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model. Neurobiol Aging. 2009 Mar 27. Abstract