Updated 9 December 2008

General Information

Transgene: 650-kb YAC with 400-kb huAPP + Swiss mutation/R1 ES cells.

Mutation: Swedish mutation KM670N/671L

Mouse Strain: Original background 129X1/SvJ x 129S1/Sv-+^P+^Tyr-cKitl^S1-J/+;
Published/distributed Background DBA/2J;
Generation: N28 (08-JAN-08)

Phenotype

Neuropathological Analysis:

Lowest level of brain and plasma Aβ40 and Aβ42 compared to B6-R1.40 and 129S1-R1.40. No Aβ deposits observed in homozygous mice at 13.5 months up to 20 months. Cross breeding with B6-R1.40 mice produced Aβ deposits thus indicating genetic dominance of B6 alleles over D2 alleles

Behavioral:

N/A

Availability

The Jackson Lab, available, stock #006472. For research or non-commercial use only.

Patents: None

References

Primary:

Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates β-amyloid precursor protein processing and β-amyloid deposition in the mouse. Hum Mol Genet. 2003 Nov 15 ; 12(22):2949-2956. Abstract

Associated:

Lamb BT; Call LM; Slunt HH; Bardel KA; Lawler AM; Eckman CB; Younkin SG; Holtz G; Wagner SL; Price DL; Sisodia SS; Gearhart JD. 1997. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum Mol Genet 6(9):1535-41. Abstract