Updated 9 December 2008

General Information

Transgene: YAC containing entire wt 300 kb human APP gene with Swedish mutation (KM670N/671L) introduced into R1 embryonic ES cells

Mutation: Swedish mutation KM670N/671L

Mouse Strain: Original background (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then to DBA/2J, N7.;
Published/distributed Background C57BL/6J;
Generation: N22+F2 (08-DEC-07)

Phenotype

Neuropathological Analysis:

Highest level of brain and plasma Aβ 40 and 42 compared to D2-R1.40 and 129S1-R1.40 mice. Homozygous 13.5-month-old mice showed Aβ deposits in parietal cortex and by 20 months substantial deposits in frontal and parietal cortex.

Behavioral:

N/A

Availability

The Jackson Lab, available, stock #005300. For research or non-commercial use only.

Patents: None

References

Primary:

Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum Mol Genet. 1997 Sep ; 6(9):1535-41. Abstract

Associated:

Kulnane LS; Lamb BT. 2001. Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice. Neurobiol Dis 8(6):982-92. Abstract

Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Hum Mol Genet. 2003 Nov 15;12(22):2949-56. Abstract

Lehman EJ, Kulnane LS, Lamb BT. Alterations in beta-amyloid production and deposition in brain regions of two transgenic models. Neurobiol Aging. 2003 Sep;24(5):645-53. Abstract

Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93. Abstract

Ryman D, Gao Y, Lamb BT. Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease. Neurobiol Aging. 2008 Aug;29(8):1190-8. Abstract

Ryman D, Lamb BT. Genetic and environmental modifiers of Alzheimer's disease phenotypes in the mouse. Curr Alzheimer Res. 2006 Dec;3(5):465-73. Abstract