Updated 16 December 2008

General Information

Transgene: YAC containing entire 300 kb human APP gene with Swedish (K670N/M671L) and London(V717I) mutation introduced into J1 ES cells/founder line J1.96

Mutation: Swedish Mutation (K670N/M671L) and London Mutation (V717I)

Mouse Strain: Original background 129S4/SvJae;
Published/distributed Background C57BL/6J;
Generation: N12+F2 (30-Apr-08)

Phenotype

Neuropathological Analysis:

High levels of Aβ peptides are detected in the brains of YAC transgenic mice expressing human APPK670N/M671L and APPV717I. Moreover, the levels of Aβ total and 42/43 are elevated in these YAC Tg expressing human APPV717I.

Behavioral:

N/A

Availability

The Jackson Lab , available, stock #006406. For research or non-commercial use only.

Patents: None

Reference

Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Hum Molec Genet. 1997;6(9):1535-41. Abstract