Updated 9 December 2008

General Information

Transgene: YAC containing entire wt 300 kb human APP gene with Swedish mutation (KM670N/671L) introduced into R1 embryonic ES cells

Mutation: Swedish mutation KM670N/671L

Mouse Strain: Original background (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then to DBA/2J, N7;
Published/distributed Background A/J;
Generation: N21+N1 (20-DEC-07)

Phenotype

Neuropathological Analysis:

Currently under analysis

Behavioral:

N/A

Availability

The Jackson Lab, available, stock #006555. For research or non-commercial use only.

Patents: None

References

Primary:

Lehman EJ, Kulnane LS, Lamb BT. Alterations in beta-amyloid production and deposition in brain regions of two transgenic models. Neurobiol Aging. 2003 Sep;24(5):645-53. Abstract

Associated:

Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93. Abstract

Ryman D, Gao Y, Lamb BT. Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease. Neurobiol Aging. 2008 Aug;29(8):1190-8. Abstract