Updated 9 December 2008
Transgene: YAC containing entire wt 300 kb human APP gene with Swedish mutation
(KM670N/671L) introduced into R1 embryonic ES cells
Mutation: Swedish mutation KM670N/671L
Mouse Strain: Original background (129X1/SvJ x 129S1/Sv); bred to C57BL/6J, then
to DBA/2J, N7;
Published/distributed Background A/J;
Generation: N21+N1 (20-DEC-07)
Currently under analysis
The Jackson Lab,
available, stock #006555. For research or non-commercial use only.
Lehman EJ, Kulnane LS, Lamb BT. Alterations in beta-amyloid production and deposition
in brain regions of two transgenic models. Neurobiol Aging. 2003 Sep;24(5):645-53.
Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers
induce neuronal cell cycle events in Alzheimer's disease. J Neurosci. 2008 Oct 22;28(43):10786-93.
Ryman D, Gao Y, Lamb BT. Genetic loci modulating amyloid-beta levels in a mouse
model of Alzheimer's disease. Neurobiol Aging. 2008 Aug;29(8):1190-8.