Click on the patent number to view the full text and images of the patent, U.S. and foreign references, related U.S. patent applications and literature citations. This service is provided by the U.S. Patent and Trademark Office web site.

Patent Number	Description	Date Filed in US	Date Issued
6548261	Alzheimer model for drug screening	12/30/98	4/15/03
6518235	Methods for improving brain function using leptin or analogs thereof	11/30/98	2/11/03
6514984	Treatment for alzheimer's disease	4/12/00	2/4/03
6514969	b-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions	7/24/01	2/4/03
6511966	Mitochondria protecting agents for treating mitochondria associated diseases	8/20/01	1/28/03
6509381	Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions	5/1/02	1/21/03
6509331	Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds	6/21/99	1/21/03
6506782	Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds	2/27/98	1/14/03
6503242	Therapeutic method for treatment of Alzheimer's disease	3/30/00	1/7/03
6495693	N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds	3/30/99	12/17/02
6492407	Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones	4/23/01	12/10/02
6486169	Botanical drug for treatment and prevention of alzheimer's disease	2/19/02	11/26/02
6472421	Methods for treating, preventing, and reducing the risk of the onset of alzheimer's disease using an HMG CoA reductase inhibitor	11/13/98	10/29/02
6471961	Interleukin antagonists for the treatment of neurological, retinal and muscular disorders	5/2/00	10/29/02
6471960	Methods for the prevention or treatment of alzheimer's disease	9/13/00	10/29/02
6469055	Compositions and methods for treatment of neurological disorders and neurodegenerative diseases	2/5/01	10/22/02
6469049	Method of treating, preventing or inhibiting central nervous system injuries and diseases	4/20/01	10/22/02
6462171	Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits	12/12/96	10/8/02
6451343	Composition for treating dementia and Alzheimer's disease	8/30/00	9/17/02
6451306	Methods for therapy of neurodegenerative disease of the brain	4/15/98	9/17/02
6444662	Stable hyperforin salts, method for producing same and their use in the treatment of alzheimer's disease	8/11/00	9/3/02
6444201	Treatment of alzheimer disease by modulation of synapsins	5/13/96	9/3/02
6436983	Treatment for alzheimer's disease	4/10/00	8/20/02
6436937	Use of desoxypeganine in the treatment of Alzheimer's dementia	8/16/01	8/20/00
6420351	Methods for treating neuropsychiatric disorders	4/13/01	7/16/02
6417229	a-sulfonylamino hydroxamic acid inhibitors of matrix metalloproteinases for the treatment of peripheral or central nervous system disorders	9/27/00	7/9/02
6413940	Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis of DMS	2/3/98	7/2/02
6399628	N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds	3/12/99	6/4/02
6391871	Preventing neuronal degeneration in Alzheimer's disease	9/27/99	5/21/02
6383159	Devices and method for removing cerebrospinal fluids from a patient's CSF space	11/10/98	5/7/02
6369058	Brain delivery of folic acid for the prevention of alzheimer's disease and stroke	1/14/00	4/19/02
6362160	Immunophilin-binding agents prevent glutamate neurotoxicity associated with vascular stroke and neurodegenerative diseases	6/30/93	3/26/02
6358990	Method for treating Alzheimer's disease	4/13/00	3/19/02
6358975	Method of using selective parp inhibitors to prevent or treat neurotoxicity	2/11/00	3/19/02
6353015	Method of treating neurodegenerative disorders	3/23/01	3/5/02
6352715	Transdermal rate-controlled delivery of Huperzine A for treatment of alzheimer's disease	6/12/00	3/5/02
6346280	Composition and methods for inhibiting the formation of brain amyloid deposits	11/24/98	2/12/02
6340709	Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing	6/25/98	1/22/02
6333351	N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds	5/3/99	12/25/01
6326507	Therapeutic compounds and methods of use	6/17/99	12/4/01
6323218	Agents for use in the treatment of Alzheimer's disease	3/11/98	11/27/01
6323198	Preparation and use of a specific GABA-A.alpha.5 receptor ligand for treatment of alzheimer's disease	7/20/00	11/27/01
6322824	Use of hyperforin and hyperforin-containing extracts in the treatment of dementia diseases	8/11/00	11/27/01
6319919	Galanthamine derivatives for treatment of alzheimer's disease	6/7/95	11/20/01
6313152	N(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds	9/7/99	11/6/01
6306912	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases	6/7/95	10/23/01
6294383	Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases	4/19/95	9/25/01
6277828	Pharmaceutical formulations of nerve growth factor	8/20/93	8/21/01
6277372	Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases	4/19/95	8/21/01
6274615	Method for delaying the onset of alzheimer's disease and for treatment or delaying the onset of other amyloidosis-related diseases/disorders	3/25/99	8/14/01
6274606	Methods of treating central nervous system disorders with aryl substituted olefinic amine compounds	10/12/98	8/14/01
6269270	Apparatus and method for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and external stimulator	10/26/98	7/31/01
6268358	Compounds for the treatment of Alzheimer's disease	6/7/95	7/31/01
6264625	Method and apparatus for treating adult-onset dementia of the Alzheimer's type	7/25/97	7/24/01
6262302	N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds	9/17/99	7/17/01
6252081	Process for production of donepezil derivative	6/27/00	6/26/01
6251928	Treatment of alzheimer's disease employing inhibitors of cathepsin D	3/16/94	6/26/01
6251903	Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist	9/13/00	6/26/01
6251863	Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin	2/18/99	6/26/01
6245911	Donepezil polycrystals and process for producing the same	6/5/00	6/12/01
6245766	Method of treating psychiatric conditions	12/18/98	6/12/01
6245751	Methods for the treatment of apolipoprotein E related diseases	9/10/99	6/12/01
6245736	Use of peptidic bradykinin antagonists for the treatment and prevention of Alzheimer's disease	10/14/97	6/12/01
6245575	Screening of agents for treatment of alzheimer's disease	7/16/99	6/12/01
6242421	Methods for preventing and treating Alzheimer's disease	6/4/99	6/5/01
6239111	In vivo method of improving survival rate of brain neurons	1/26/98	5/29/01
6235769	Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase	7/2/98	5/22/01
6228878	Methods for treating or preventing alzheimer's disease using substituted 2-aryl-3-morpholinopropanones	8/10/99	5/8/01
6228875	Methods for treating neuropsychiatric disorders	4/14/99	5/8/01
6218405	Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them	6/16/99	4/17/01
6218404	Subtype-selective NMDA receptor ligands and the use thereof	9/16/98	4/17/01
6218383	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders	8/7/98	4/17/01
6214334	Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries	5/3/99	4/10/01
6211245	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases	11/4/98	4/3/01
6211235	Compounds for inhibiting .beta.-amyloid peptide release and/or its synthesis	9/30/98	4/3/01
6207803	Human requiem	1/19/99	3/27/01
6207710	Compounds for inhibiting .beta.-amyloid peptide release and/or its synthesis	9/30/98	3/27/01
6204281	Method of treatment and pharmaceutical composition	7/8/99	3/20/01
6204053	Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases	4/19/95	3/20/01
6200990	Neuroprotective agents having antioxidant and NMDA antagonist activity	12/14/99	3/13/01
6194581	Substituted pyridines useful as modulators of acetylcholine receptors	12/22/98	2/27/01
6194404	Process for the isolation of galanthamine	8/7/98	2/27/01
6194403	Tacrine derivatives for treating Alzheimer's disease	9/9/99	2/27/01
6191166	Methods and compounds for inhibiting .beta.-amyloid peptide release and/or its synthesis	11/21/97	2/20/01
6191154	Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases	11/27/98	2/20/01
6187785	Agent for treating neurodegenerative disorders	3/25/99	2/13/01
6187756	Composition and methods for treatment of neurological disorders and neurodegenerative diseases	1/28/00	2/13/01
6184248	Compositions and methods for treatment of neurological disorders and neurodegenerative diseases	11/8/99	2/6/01
6184236	Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative	8/9/99	2/6/01
6180603	Method for administering neurologic agents to the brain	1/8/97	1/30/01
6177472	Regulation of alzheimer's disease proteins and uses thereof	10/27/98	1/23/01
6177077	TNT inhibitors for the treatment of neurological disorders	12/31/99	1/23/01
6172055	Apoptosis inhibitors for treating neurodegenerative diseases	8/14/98	1/9/01
6172043	Treatments for neurotoxicity in Alzheimer's disease caused by .beta. amyloid peptides	1/9/98	1/9/01
6172041	Use of conantokins	2/10/99	1/9/01
6169115	Use of aminoguanidine analogs for the treatment of diseases of the nervous system	5/21/99	1/2/01
6166209	Piperidine derivatives	11/20/98	12/26/00
6161044	Method and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation	11/23/98	12/12/00
6153652	N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds	11/21/97	11/28/00
6150354	Compounds for the treatment of Alzheimer's disease	10/19/93	11/21/00
6140369	Benzamides for neurodegenerative disorder treatment	9/7/99	10/31/00
6136832	5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones and methods of use therefor	5/19/99	10/24/00
6136548	Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging	9/2/99	10/24/00
6133299	Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds	2/25/93	10/17/00
6133259	Alkyl, alkenyl and alkynyl chrysamine G derivatives for inhibition of cell degeneration and toxicity associated with amyloid deposition	11/9/98	10/17/00
6127370	Method for treating alzheimer's disease	11/8/99	10/3/00
6124456	Pyrazolopyridine compound and pharmaceutical use thereof	1/19/99	9/26/00
6117912	Sublingual and buccal administration of selegiline for treating certain selegiline-responsive diseases and conditions	4/28/98	9/12/00
6114365	Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents	8/12/99	9/5/00
6114334	Piperazine derivatives as therapeutic agents	12/17/97	9/5/00
6107310	Heteroarylcarboxamide derivatives for treating CNS disorders	6/16/98	8/22/00
6103754	Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof	3/9/98	8/15/00
6100269	Pharmaceutical compositions for prevention and treatment of central nervous system disorders	5/6/99	8/8/00
6087372	Method of enhancing cognition with 2-(4-methoxyphenyl)-pyrazolo[4,3-c]quinolin-3-one	5/25/99	7/11/00
6077852	Treatment of central nervous system disorders with selective estrogen receptor modulators	4/9/98	6/20/00
6071970	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases	6/7/95	6/6/00
6071694	Screening method for therapeutic agents against Alzheimer's disease	6/5/95	6/6/00
6060516	N.sup.1 -propargylhydrazines, N.sup.2 -propargylhydrazines and their analogs for the treatment of depression, anxiety and neurodegeneration	2/17/98	5/9/00
6060048	Method for transplanting cells into the brain and therapeutic uses therefor	6/2/95	5/9/00
6056725	Therapeutic method for treatment of alzheimer's disease	8/3/98	5/2/00
6051684	Methods of treating neurodegenerative disorders using protease inhibitors	5/17/95	4/18/00
6051610	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases	2/18/99	4/18/00
6043224	Compositions and methods for treatment of neurological disorders and neurodegenerative diseases	9/5/97	3/28/00
6037327	Specific saccharide compositions and methods for treating Alzheimer's disease and other amyloidoses	8/28/98	3/14/00
6034119	Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof	2/18/99	3/7/00
6034080	Use of Maillard reaction inhibitors for the treatment of amyloidosis-based disease	12/4/98	3/7/00
6030984	Pyridone compounds useful in treating Alzheimer's disease	9/28/98	2/29/00
6025395	Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders	4/14/97	2/15/00
6022859	Inhibitors of .beta.-amyloid toxicity	11/14/97	2/8/00
6017965	Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases	12/11/96	1/25/00
6017913	Naphthylazo inhibition of amyloidosis	5/3/99	1/25/00
5990132	Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders	6/17/96	11/23/99
5985936	Method of preventing and delaying onset of Alzheimer's disease and composition therefore	12/18/97	11/16/99
5985930	Treatment of neurodegenerative conditions with nimesulide	4/1/97	11/16/99
5985581	Use of presenilin-1 for diagnosis of alzheimers disease	7/17/97	11/16/99
5981508	Facilitation of repair of neural injury with CM101/GBS toxin	1/29/97	11/9/99
5980933	Transdermal formulation of xanomeline	9/29/97	11/9/99
5980480	Method and apparatus for treating adult-onset dementia of the alzheimer's type	7/11/96	11/9/99
5977181	Therapeutic uses for nitric oxide inhibitors	11/13/97	11/2/99
5972956	Inhibition of amyloidosis by 9-acridinones	4/29/98	10/26/99
5958964	Use of melatonin to prevent cytotoxic effects of amyloid beta protein	2/18/97	9/28/99
5958919	Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration	9/20/96	9/28/99
5952349	Muscarinic antagonists for treating memory loss	7/8/97	9/14/99
5948800	Preventive or therapeutic drug for Alzheimer's disease	8/4/97	9/7/99
5948763	Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits	4/10/96	9/7/99
5928882	Treatment and prevention of neurodegenerative diseases using modulators of Fe65	10/24/97	7/27/99
5900409	Cerebration improver	11/2/95	5/4/99
5891887	Uses of [R-(Z)]-.alpha.-(methoxyimino)-.alpha.-(1-azabicyclo [2.2.2.] oct-3-yl)	4/25/97	4/6/99
5891923	R-enantiomer of N-propargyl-1-aminoindan for the treatment of dementia	6/6/95	4/6/99
5886023	Agent for improving dementia	5/22/95	3/23/99
5880116	Use of celastrol to treat alzheimer's disease	12/13/96	3/09/99
5880256	Factor VIIa inhibitors from Kunitz domain proteins	3/03/95	3/09/99
5877173	Preventing neuronal degeneration in Alzheimer's disease	8/28/96	3/2/99
5876948	Screening methods to identify neurotoxin inhibitors	7/29/91	3/2/99