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Home: Research: Compendia
Therapeutics 

Updated 16 December 2003

Important Notice: We are striving to include as many patents as possible, but we do not make a claim to being comprehensive. We may inadvertently omit specific patents due to a lack of information. If you notice an omission, please contact junekino@alzforum.org.

Click on the patent number to view the full text and images of the patent, U.S. and foreign references, related U.S. patent applications and literature citations. This service is provided by the U.S. Patent and Trademark Office web site.

Patent Number 
Description 
Date Filed in US
Date Issued
6548261 Alzheimer model for drug screening 12/30/98 4/15/03
6518235 Methods for improving brain function using leptin or analogs thereof 11/30/98 2/11/03
6514984 Treatment for alzheimer's disease 4/12/00 2/4/03
6514969 b-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions 7/24/01 2/4/03
6511966 Mitochondria protecting agents for treating mitochondria associated diseases 8/20/01 1/28/03
6509381 Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions 5/1/02 1/21/03
6509331 Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds 6/21/99 1/21/03
6506782 Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds 2/27/98 1/14/03
6503242 Therapeutic method for treatment of Alzheimer's disease 3/30/00 1/7/03
6495693 N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds 3/30/99 12/17/02
6492407 Pharmaceutical compositions containing triazolones and methods of treating neurodegenerative disease using triazolones 4/23/01 12/10/02
6486169 Botanical drug for treatment and prevention of alzheimer's disease 2/19/02 11/26/02
6472421 Methods for treating, preventing, and reducing the risk of the onset of alzheimer's disease using an HMG CoA reductase inhibitor 11/13/98 10/29/02
6471961 Interleukin antagonists for the treatment of neurological, retinal and muscular disorders 5/2/00 10/29/02
6471960 Methods for the prevention or treatment of alzheimer's disease 9/13/00 10/29/02
6469055 Compositions and methods for treatment of neurological disorders and neurodegenerative diseases 2/5/01 10/22/02
6469049 Method of treating, preventing or inhibiting central nervous system injuries and diseases 4/20/01 10/22/02
6462171 Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits 12/12/96 10/8/02
6451343 Composition for treating dementia and Alzheimer's disease 8/30/00 9/17/02
6451306 Methods for therapy of neurodegenerative disease of the brain 4/15/98 9/17/02
6444662 Stable hyperforin salts, method for producing same and their use in the treatment of alzheimer's disease 8/11/00 9/3/02
6444201 Treatment of alzheimer disease by modulation of synapsins 5/13/96 9/3/02
6436983 Treatment for alzheimer's disease 4/10/00 8/20/02
6436937 Use of desoxypeganine in the treatment of Alzheimer's dementia 8/16/01 8/20/00
6420351 Methods for treating neuropsychiatric disorders 4/13/01 7/16/02
6417229 a-sulfonylamino hydroxamic acid inhibitors of matrix metalloproteinases for the treatment of peripheral or central nervous system disorders 9/27/00 7/9/02
6413940 Pharmaceutically active agents that impede the formation of amyloid by impeding the genesis of DMS 2/3/98 7/2/02
6399628 N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds 3/12/99 6/4/02
6391871 Preventing neuronal degeneration in Alzheimer's disease 9/27/99 5/21/02
6383159 Devices and method for removing cerebrospinal fluids from a patient's CSF space 11/10/98 5/7/02
6369058 Brain delivery of folic acid for the prevention of alzheimer's disease and stroke 1/14/00 4/19/02
6362160 Immunophilin-binding agents prevent glutamate neurotoxicity associated with vascular stroke and neurodegenerative diseases 6/30/93 3/26/02
6358990 Method for treating Alzheimer's disease 4/13/00 3/19/02
6358975 Method of using selective parp inhibitors to prevent or treat neurotoxicity 2/11/00 3/19/02
6353015 Method of treating neurodegenerative disorders 3/23/01 3/5/02
6352715 Transdermal rate-controlled delivery of Huperzine A for treatment of alzheimer's disease 6/12/00 3/5/02
6346280 Composition and methods for inhibiting the formation of brain amyloid deposits 11/24/98 2/12/02
6340709 Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing 6/25/98 1/22/02
6333351 N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds 5/3/99 12/25/01
6326507 Therapeutic compounds and methods of use 6/17/99 12/4/01
6323218 Agents for use in the treatment of Alzheimer's disease 3/11/98 11/27/01
6323198 Preparation and use of a specific GABA-A.alpha.5 receptor ligand for treatment of alzheimer's disease 7/20/00 11/27/01
6322824 Use of hyperforin and hyperforin-containing extracts in the treatment of dementia diseases 8/11/00 11/27/01
6319919 Galanthamine derivatives for treatment of alzheimer's disease 6/7/95 11/20/01
6313152 N(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds 9/7/99 11/6/01
6306912 Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 6/7/95 10/23/01
6294383 Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases 4/19/95 9/25/01
6277828 Pharmaceutical formulations of nerve growth factor 8/20/93 8/21/01
6277372 Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases 4/19/95 8/21/01
6274615 Method for delaying the onset of alzheimer's disease and for treatment or delaying the onset of other amyloidosis-related diseases/disorders 3/25/99 8/14/01
6274606 Methods of treating central nervous system disorders with aryl substituted olefinic amine compounds 10/12/98 8/14/01
6269270 Apparatus and method for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and external stimulator 10/26/98 7/31/01
6268358 Compounds for the treatment of Alzheimer's disease 6/7/95 7/31/01
6264625 Method and apparatus for treating adult-onset dementia of the Alzheimer's type 7/25/97 7/24/01
6262302 N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds 9/17/99 7/17/01
6252081 Process for production of donepezil derivative 6/27/00 6/26/01
6251928 Treatment of alzheimer's disease employing inhibitors of cathepsin D 3/16/94 6/26/01
6251903 Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones and the use thereof as glycine receptor antagonist 9/13/00 6/26/01
6251863 Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin 2/18/99 6/26/01
6245911 Donepezil polycrystals and process for producing the same 6/5/00 6/12/01
6245766 Method of treating psychiatric conditions 12/18/98 6/12/01
6245751 Methods for the treatment of apolipoprotein E related diseases 9/10/99 6/12/01
6245736 Use of peptidic bradykinin antagonists for the treatment and prevention of Alzheimer's disease 10/14/97 6/12/01
6245575 Screening of agents for treatment of alzheimer's disease 7/16/99 6/12/01
6242421 Methods for preventing and treating Alzheimer's disease 6/4/99 6/5/01
6239111 In vivo method of improving survival rate of brain neurons 1/26/98 5/29/01
6235769 Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase 7/2/98 5/22/01
6228878 Methods for treating or preventing alzheimer's disease using substituted 2-aryl-3-morpholinopropanones 8/10/99 5/8/01
6228875 Methods for treating neuropsychiatric disorders 4/14/99 5/8/01
6218405 Heteroarylsulfonamide derivatives and pharmaceutical compositions containing them 6/16/99 4/17/01
6218404 Subtype-selective NMDA receptor ligands and the use thereof 9/16/98 4/17/01
6218383 Pharmaceutical compositions for the prevention and treatment of central nervous system disorders 8/7/98 4/17/01
6214334 Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries 5/3/99 4/10/01
6211245 Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 11/4/98 4/3/01
6211235 Compounds for inhibiting .beta.-amyloid peptide release and/or its synthesis 9/30/98 4/3/01
6207803 Human requiem 1/19/99 3/27/01
6207710 Compounds for inhibiting .beta.-amyloid peptide release and/or its synthesis 9/30/98 3/27/01
6204281 Method of treatment and pharmaceutical composition 7/8/99 3/20/01
6204053 Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases 4/19/95 3/20/01
6200990 Neuroprotective agents having antioxidant and NMDA antagonist activity 12/14/99 3/13/01
6194581 Substituted pyridines useful as modulators of acetylcholine receptors 12/22/98 2/27/01
6194404 Process for the isolation of galanthamine 8/7/98 2/27/01
6194403 Tacrine derivatives for treating Alzheimer's disease 9/9/99 2/27/01
6191166 Methods and compounds for inhibiting .beta.-amyloid peptide release and/or its synthesis 11/21/97 2/20/01
6191154 Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases 11/27/98 2/20/01
6187785 Agent for treating neurodegenerative disorders 3/25/99 2/13/01
6187756 Composition and methods for treatment of neurological disorders and neurodegenerative diseases 1/28/00 2/13/01
6184248 Compositions and methods for treatment of neurological disorders and neurodegenerative diseases 11/8/99 2/6/01
6184236 Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative 8/9/99 2/6/01
6180603 Method for administering neurologic agents to the brain 1/8/97 1/30/01
6177472 Regulation of alzheimer's disease proteins and uses thereof 10/27/98 1/23/01
6177077 TNT inhibitors for the treatment of neurological disorders 12/31/99 1/23/01
6172055 Apoptosis inhibitors for treating neurodegenerative diseases 8/14/98 1/9/01
6172043 Treatments for neurotoxicity in Alzheimer's disease caused by .beta. amyloid peptides 1/9/98 1/9/01
6172041 Use of conantokins 2/10/99 1/9/01
6169115 Use of aminoguanidine analogs for the treatment of diseases of the nervous system 5/21/99 1/2/01
6166209 Piperidine derivatives 11/20/98 12/26/00
6161044 Method and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation 11/23/98 12/12/00
6153652 N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds 11/21/97 11/28/00
6150354 Compounds for the treatment of Alzheimer's disease 10/19/93 11/21/00
6140369 Benzamides for neurodegenerative disorder treatment 9/7/99 10/31/00
6136832 5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones and methods of use therefor 5/19/99 10/24/00
6136548 Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging 9/2/99 10/24/00
6133299 Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds 2/25/93 10/17/00
6133259 Alkyl, alkenyl and alkynyl chrysamine G derivatives for inhibition of cell degeneration and toxicity associated with amyloid deposition 11/9/98 10/17/00
6127370 Method for treating alzheimer's disease 11/8/99 10/3/00
6124456 Pyrazolopyridine compound and pharmaceutical use thereof 1/19/99 9/26/00
6117912 Sublingual and buccal administration of selegiline for treating certain selegiline-responsive diseases and conditions 4/28/98 9/12/00
6114365 Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents 8/12/99 9/5/00
6114334 Piperazine derivatives as therapeutic agents 12/17/97 9/5/00
6107310 Heteroarylcarboxamide derivatives for treating CNS disorders 6/16/98 8/22/00
6103754 Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof 3/9/98 8/15/00
6100269 Pharmaceutical compositions for prevention and treatment of central nervous system disorders 5/6/99 8/8/00
6087372 Method of enhancing cognition with 2-(4-methoxyphenyl)-pyrazolo[4,3-c]quinolin-3-one 5/25/99 7/11/00
6077852 Treatment of central nervous system disorders with selective estrogen receptor modulators 4/9/98 6/20/00
6071970 Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 6/7/95 6/6/00
6071694 Screening method for therapeutic agents against Alzheimer's disease 6/5/95 6/6/00
6060516 N.sup.1 -propargylhydrazines, N.sup.2 -propargylhydrazines and their analogs for the treatment of depression, anxiety and neurodegeneration 2/17/98 5/9/00
6060048 Method for transplanting cells into the brain and therapeutic uses therefor 6/2/95 5/9/00
6056725 Therapeutic method for treatment of alzheimer's disease 8/3/98 5/2/00
6051684 Methods of treating neurodegenerative disorders using protease inhibitors 5/17/95 4/18/00
6051610 Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 2/18/99 4/18/00
6043224 Compositions and methods for treatment of neurological disorders and neurodegenerative diseases 9/5/97 3/28/00
6037327 Specific saccharide compositions and methods for treating Alzheimer's disease and other amyloidoses 8/28/98 3/14/00
6034119 Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof 2/18/99 3/7/00
6034080 Use of Maillard reaction inhibitors for the treatment of amyloidosis-based disease 12/4/98 3/7/00
6030984 Pyridone compounds useful in treating Alzheimer's disease 9/28/98 2/29/00
6025395 Method of preventing or delaying the onset and progression of Alzheimer's disease and related disorders 4/14/97 2/15/00
6022859 Inhibitors of .beta.-amyloid toxicity 11/14/97 2/8/00
6017965 Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases 12/11/96 1/25/00
6017913 Naphthylazo inhibition of amyloidosis 5/3/99 1/25/00
5990132 Polycyclic systems, and derivatives thereof, as neurotransmitter release enhancers useful in the treatment of cognitive disorders 6/17/96 11/23/99
5985936 Method of preventing and delaying onset of Alzheimer's disease and composition therefore 12/18/97 11/16/99
5985930 Treatment of neurodegenerative conditions with nimesulide 4/1/97 11/16/99
5985581 Use of presenilin-1 for diagnosis of alzheimers disease 7/17/97 11/16/99
5981508 Facilitation of repair of neural injury with CM101/GBS toxin 1/29/97 11/9/99
5980933 Transdermal formulation of xanomeline 9/29/97 11/9/99
5980480 Method and apparatus for treating adult-onset dementia of the alzheimer's type 7/11/96 11/9/99
5977181 Therapeutic uses for nitric oxide inhibitors 11/13/97 11/2/99
5972956 Inhibition of amyloidosis by 9-acridinones 4/29/98 10/26/99
5958964  Use of melatonin to prevent cytotoxic effects of amyloid beta protein 2/18/97 9/28/99
5958919 Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration 9/20/96 9/28/99
5952349 Muscarinic antagonists for treating memory loss 7/8/97 9/14/99
5948800 Preventive or therapeutic drug for Alzheimer's disease 8/4/97 9/7/99 
5948763 Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits 4/10/96 9/7/99
5928882 Treatment and prevention of neurodegenerative diseases using modulators of Fe65 10/24/97 7/27/99
5900409  Cerebration improver 11/2/95  5/4/99
5891887  Uses of [R-(Z)]-.alpha.-(methoxyimino)-.alpha.-(1-azabicyclo [2.2.2.] oct-3-yl) 4/25/97  4/6/99
5891923  R-enantiomer of N-propargyl-1-aminoindan for the treatment of dementia 6/6/95  4/6/99
5886023  Agent for improving dementia 5/22/95  3/23/99
5880116  Use of celastrol to treat alzheimer's disease 12/13/96  3/09/99
5880256  Factor VIIa inhibitors from Kunitz domain proteins 3/03/95  3/09/99
5877173  Preventing neuronal degeneration in Alzheimer's disease 8/28/96  3/2/99
5876948  Screening methods to identify neurotoxin inhibitors 7/29/91  3/2/99
5874424  Inhibitors of interleukin-1.beta. converting enzyme 2/8/96  2/23/99
5874421  Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide 6/6/95  2/23/99
5874277  Proteins, their production and use 4/4/97  2/23/99
5872101  Methods of treating neurodegenerative disorders using protease inhibitors 5/18/95  2/16/99
5869500 Pyridone compounds useful in treating Alzheimer's disease 11/24/97 2/9/99
5864018  Antibodies to advanced glycosylation end-product receptor polypeptides and uses therefor 4/16/96  1/26/99
5863893  Factor VIIa inhibitors from kunitz domain proteins 3/3/95  1/26/99
5863902  Methods of treating neurodegenerative disorders using protease inhibitors 5/18/95  1/26/99
5856169  Isoforms of human interleukin-1.beta. converting enzyme and methods of using the same 2/21/95  1/5/99
5854215  Modulators of .beta.-amyloid peptide aggregation 6/07/95  12/29/98
5854204  A.beta. peptides that modulate beta.-amyloid aggregation 5/14/95  12/29/98
5851996  Materials and methods for treatment of plaquing diseases 2/13/98  12/22/98
5849782 Methods of inhibiting neurodegenerative diseases 7/12/96 12/15/98
5847135  Inhibitors of interleukin-1.beta. converting enzyme 5/25/95 12/8/98
5847074  Phospholipase C-inhibiting peptides  5/5/95 12/8/98
5843904  Inhibitors of interleukin-1.beta.converting enzyme  12/20/95 12/1/98
5843695 Method for decomposing amyloid protein precursor and amyloid .beta.-protein 4/30/96 12/1/98
5840746  Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases  9/5/97 11/24/98
5837853 Preventive or therapeutic agents for alzheimers disease a screening method of alzheimers disease and tau-protein kinase I originated from human being 2/20/96 11/17/98
5837707  Dimeric piperidine, tetrahydropyridine and piperazine derivatives   6/6/95  11/17/98
5834244  Factor VIIa inhibitors from Kunitz domain proteins  3/3/95  11/10/98
5833988  Transferrin receptor specific antibody- neuropharmaceutical or diagnostic agent conjugates  4/18/96 11/10/98
5830910  Cytochalasins useful in providing protection against nerve cell injury associated with neurodegenerative disorders  10/23/95 11/3/98
5830896  Dimeric piperidine, tetrahydropyridine and piperazine derivatives  6/7/95 11/3/98
5824692  Pharmaceutical compositions for prevention and treatment of central nervous system disorders  1/6/95  10/20/98 
5817656   Mental Disorders (2-Methyl-4-(4-methyl-1- piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiazepine   11/13/96   10/6/98 
5817655  Methods of treatment using a thieno- benzodiazepine  11/13/96 10/6/98
5817626  Modulators of beta-amyloid peptide aggregation  3/14/95  10/6/98
5804560  Peptide and peptide analog protease inhibitors  1/6/95  9/8/98
5807871  Piperidine derivatives having anxiolytic effect  6/7/95 9/15/98
5807887  Agent for potentiating nerve growth factor activity containing 1,2-ethanediol derivative or salt thereof  4/23/97 9/15/98
5804560  Peptide and petide analogs of protease inhibitors 1/6/95 9/8/98
5801184  Carbon monoxide dependent guanylyl cyclase modifiers and methods of use  6/8/95 9/1/98
5798102 Treatment of cardiomyopathy 3/4/97 8/25/98
5795954  Factor VIIa inhibitors from Kunitz domain proteins  3/4/94 8/18/98
5786328  Use of kunitz type plasma kallikrein inhibitors  6/5/95 7/28/98
5786187  Method for reducing neuronal degeneration associated with seizure  9/21/95 7/28/98
5780587  Compounds and methods for inhibiting .beta.-protein filament formation and neurotoxicity  4/6/95  7/14/98
5780265  Kunitz type plasma kallikrein inhibitors  6/5/95 7/14/98
5778893  Method of diagnosing and monitoring a treatment for Alzheimer's disease  5/19/95  7/14/98
5776946  Peripheral benzodiazepine receptor ligands as antiinflammatory agents  8/28/95 7/7/98
5773466 Pharmaceutical product comprising sympathomimetic drug havingtherapeutic properties on the human sensibility and autocinesis in general 11/1/96 6/30/98
5762953 Transdermal propentofylline compositions for the treatment of Alzheimers disease 8/22/96 6/9/98
5756482  Method of attenuation of nervous system damage  6/16/96  5/26/98
5756084  Human stromal derived factor 1.alpha. and 1.beta.   7/1/96  5/26/98
5753624  Materials and methods for treatment of plaquing disease 8/8/96 5/19/98
5750542  Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors  9/28/93 5/12/98
5744476   Dopamine D.sub.1 agonists for the treatment of dementia 6/27/94 4/28/98 
5736546 1,4-(diphenlyalkyl) piperazine derivatives 3/25/96 4/7/98
5733926  Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions 12/13/96 3/31/98
5723496  Method for prevention and treatment of harmful effects of intracellular acidosis 3/15/95 3/3/98
5716929  Inhibitors of interleukin-1.beta. converting enzyme 6/5/95 2/10/98
5714471  Peptide and peptide analog protease inhibitors 5/17/95 2/3/98
5708007  2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin- 4-yl) benzofuran-7-ol and carbamate derivatives for treating memory dysfunction  8/27/96 1/13/98
5693668 Acetylcholinesterase inhibitors  1/31/95 12/2/97
5693614  Drug for the treatment of senile dementia of the ischemic and hypoglycemic types  6/14/94 12/2/97
5691368  Substituted oxazolidine calpain and/or cathepsin B inhibitors 12/11/95 11/25/97
5691201  Use of sabeluzole in chronic neurodegenerative diseases 10/11/95 11/25/97
5684012  Dimeric piperidine, tetrahydropyridine and piperazine derivatives  6/7/95 11/4/97
5683422  Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation   4/25/96 11/4/97
5665725  Piperidine derivatives having anxiolytic effect  12/13/93 9/9/97
5665706  Nerve growth induction, stimulation and maintenance and enzyme potentiation  10/12/95 9/9/97
5658924  1,8-naphthyridin-2-one derivative and use thereof   6/1/95 8/19/97
5658921  Dimeric piperidine, tetrahydropyridine and piperazine derivatives  12/12/94 8/19/97
5656627  Inhibitors of interleukin-1.beta. converting enzyme  3/17/95 8/12/97
5650148  Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system  3/10/94 7/22/97
5643960  Method of delaying onset of alzheimer's disease symptoms 4/15/94  7/1/97
5629165 Neural calcium-activated neutral proteinase inhibitors  2/25/94 5/13/97
5605897  2-methyl-thieno-benzodiazepine 2/13/95 2/25/97
5594000  Spirofurane derivatives 6/6/95 1/14/97
5583140  Pharmaceutical compositions for the treatment of central nervous system disorders  5/17/95 12/10/96
5580898  Method of stabilizing microtubules  5/24/94 12/3/96
5576353  Method of treating memory disorders using R-enantiomers of N-propargyl-aminoindan compounds  6/2/95 11/19/96
5567724  Alkaline and acid phosphatase inhibitors in treatment of neurological disorders  6/1/94 10/22/96
5547965  Use of substituted amines for the treatment of brain function disorders  4/19/95 8/20/96
5538983  Method of treating amyloidosis by modulation of calcium  4/29/94  7/23/96
5538968  Geneserine derivatives processes as cholinesterase inhibitors  3/3/94 7/23/96
5535760  Method for detecting and treating Alzheimer's disease 3/24/95 7/16/96
5532219 Dapsone and promin for the treatment of dementia 4/5/93 7/2/96
5523295  Method for treating and preventing alzheimer's disease 7/6/94 6/4/96
5516772  K-252 derivatives which enhance neurotrophin-induced activity   9/16/94 5/14/96
5506097  Method for inhibiting .beta.-protein enzymatic activity  1/10/94  4/9/96
5492913  N-benzylpiperazine compounds   3/23/94 2/20/96
5486541  Monofluorinated derivatives of N-propargyl-1- aminoindan and their use as inhibitors of monoamine oxidase  9/22/94 1/23/96
5482938  Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment  2/1/94 1/9/96
5480645  Hydroxyamines N-acyl derivatives having scavenger activity and useful in acute and chronic pathologies associated with peroxidation and inflammation phenomena  12/29/93 1/2/96
5478857 Use of PLA2 inhibitors as treatment for alzheimer's disease 12/23/93 12/26/95
5470951  Peptides for antagonizing the effects of amyloid .beta.protein  9/29/93 11/28/95
5468726  Treatment of neuropsychiatric disorders  2/23/90 11/21/95
5457133 R-enantiomers of N-propargyl-aminoindan compounds, their preparation and pharmaceutical compositions containing them  2/17/94 10/10/95
5453428  Method and composition for the treatment of apathy-amotivation syndrome  9/7/93 9/26/95
5447939  Carbon monoxide dependent guanylyl cyclase modifiers and methods of use  7/25/94 9/5/95
5428043  Tricyclic-cyclic amines as novel cholinesterase inhibitors  10/29/92 6/27/95
5399565  Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations thereof  11/12/93 3/21/95
5385915  Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation 6/7/93 1/31/95
5380878  Benzo[b]thiophen-5-yl derivative and process for producing the same  3/29/94 1/10/95
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