In accordance with the recent change
in the U.S. patent system under the American Inventors Protection
Act, the United States Patent and Trademark Office (USPTO) made
application available before it is patented. Published applications
are important reference materials for patent examiners and a valuable
resource to the public. For more information, please check USPTO
announcement.
Click on the Application number to view the full text and images
of the application. This service is provided by the U.S.
Patent and Trademark Office web site.
|
6509381 |
Method of preparing and using compositions extracted from vegetable matter for the treatment of neurological conditions |
5/1/02 |
1/21/03 |
|
6486169
|
Botanical drug for treatment and prevention of alzhimer's disease |
2/19/02 |
11/26/02 |
6472145
|
Method and composition for modulating amyloidosis |
6/5/01 |
10/29/02 |
|
6458549
|
Methods of diagnosing renal salt wasting syndrome and Alzheimer's disease and methods of treating the same |
6/11/98 |
10/1/02 |
|
6455552
|
Combination of a GABA a.5 inverse agonist and a muscarinic agonist |
8/24/00 |
9/24/02 |
|
6420429
|
Brain targeted low molecular weight hydrophobic antioxidant compounds |
6/1/99 |
7/16/02 |
|
6391914
|
Optically active aminopentane derivatives |
6/16/00 |
5/21/02 |
|
6369058
|
Brain delivery of folic acid for the prevention of alzheimer's disease and stroke |
1/14/00 |
4/9/02 |
|
6350856 |
Cytokine suppressive anti-inflammatory drug binding protein
|
3/24/98 |
2/26/02 |
|
6346280 |
Composition and methods for inhibiting the formation of brain amyloid
deposits |
11/24/98 |
2/12/02 |
|
6344323 |
Compositions and methods for inhibiting cox-2 expression and treating cox-2
associated disorders by using cox-2 antisense oligonucleotides |
9/16/99 |
2/5/02 |
|
6335328 |
Process for the isolation of galanthamine |
12/21/00 |
1/1/02 |
|
6333317 |
Regulation of amyloid precursor protein (APP) expression by administration
of an estrogenic compound |
3/27/98 |
12/25/01 |
|
6329155 |
Methods of identifying agents which regulate release of amyloid
precursor protein |
4/15/94 |
12/11/01 |
|
6323198 |
Preparation and use of a specific GABA-A.a.5 receptor ligand
for treatment of alzheimer's disease |
7/20/00 |
11/27/01 |
|
6319700 |
Human choline acetyltransferase |
12/15/98 |
11/20/01 |
|
6316405 |
Cyclosporin a conjugates and uses therefor |
2/22/99 |
11/13/01 |
|
6313176 |
Dosing method of administering deprenyl via intraoral administration
or inhalation administration |
3/14/00 |
11/6/01 |
|
6310213 |
Ethanesulfonyl-piperidine derivatives |
6/2/00 |
10/30/01 |
|
6294554 |
Muscarinic antagonists |
8/30/00 |
9/25/01 |
|
6277993 |
Intermediates for 5-substituted-3-oxadiazolyl-1,6-Naphthyridin-2(1H)-one
derivatives |
9/1/00 |
8/21/01 |
|
6277886 |
Pharmaceutical compositions comprising S-(-)-N-propargyl-1-aminoindan |
1/11/99 |
8/21/01 |
|
6270077 |
Non-competitive memory enhancement game |
12/20/99 |
8/7/01 |
|
6251903 |
Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
and the use thereof as glycine receptor antagonist |
9/13/00 |
6/26/01 |
|
6251669 |
Neuronal progenitor cells and uses thereof |
1/5/98 |
6/26/01 |
|
6245884 |
Secretases related to alzheimer's dementia |
10/16/98 |
6/12/01 |
|
6245572 |
Flow cytometric characterization of amyloid fibrils |
4/30/99 |
6/12/01 |
|
6245540 |
Human choline acetyltransferase |
6/5/95 |
6/12/01 |
|
6242448 |
Trisubstituted-oxazole derivatives as serotonin ligands |
12/13/99 |
6/5/01 |
|
6239179 |
N-aminoalkyl-2-anthracenecarboxamides; new dopamine receptor
subtype specific ligands |
2/4/00 |
5/29/01 |
|
6239111 |
In vivo method of improving survival rate of brain neurons |
1/26/98 |
5/29/01 |
|
6221670 |
Methods to identify .beta.-amyloid reducing agents |
3/21/97 |
4/24/01 |
|
6221667 |
Method and composition for modulating amyloidosis |
8/25/99 |
4/24/01 |
|
6221662 |
Tryptamine treated, human differentiated, neuronal alzheimer-like
cell and attendant methods of cell modeling |
8/27/99 |
4/24/01 |
|
6214569 |
Methods for screening for inhibitors of Alzheimer .beta.-peptide
filament formation |
8/19/97 |
4/10/01 |
|
6210974 |
Compositions and methods for promoting nerve regeneration |
4/7/99 |
4/3/01 |
|
6204387 |
Process for making diaryl pyridines useful as COX-2 inhibitors |
3/23/00 |
3/20/01 |
|
6204292 |
Bicyclic metabotropic glutamate receptor ligands |
7/17/98 |
3/20/01 |
|
6204261 |
Inhibitors of interleukin-1.beta. Converting enzyme inhibitors |
12/6/96 |
3/20/01 |
|
6194410 |
Pyrazolopyrimidine and pyrazolines and process for preparation
thereof |
2/24/99 |
2/27/01 |
|
6194404 |
Process for the isolation of galanthamine |
8/7/97 |
2/27/01 |
|
6184351 |
a-synuclein super-mutants accelerate a-synuclein
aggregation |
9/24/99 |
2/6/01 |
|
6184237 |
Substituted pyridine compounds and methods of use |
11/1/99 |
2/6/01 |
|
6184200 |
Truncated glial cell line-derived neurotrophic factor |
9/28/95 |
2/6/01 |
|
6180649 |
1-(4-piperidyl)-benzimidazoles having neurotrophic activity |
11/19/98 |
1/30/01 |
|
6177458 |
Isochroman compounds and their production process |
11/21/99 |
1/23/01 |
|
6175015 |
Fused indolecarboxamides: dopamine receptor subtype specific
ligands |
10/28/99 |
1/16/01 |
|
6172086 |
Methods and compositions for stimulating neurite growth |
11/23/98 |
1/9/01 |
|
6172041 |
Use of conantokins |
2/10/99 |
1/9/01 |
|
6166209 |
Piperidine derivatives |
11/20/98 |
12/26/00 |
|
6161044 |
Method and apparatus for treating chronic pain syndromes, tremor,
dementia and related disorders and for inducing electroanesthesia
using high frequency, high intensity transcutaneous electrical
nerve stimulation |
11/23/98 |
12/12/00 |
|
6156787 |
Substituted thienlycyclohexanone derivatives for enhancing cognition |
4/22/99 |
12/5/00 |
|
6156761 |
Substituted tetralone derivatives for enhancing cognition |
4/22/99 |
12/5/00 |
|
6153652 |
N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical
compositions comprising same, and methods for inhibiting .beta.-amyloid
peptide release and/or its synthesis by use of such compounds |
11/21/97 |
11/28/00 |
|
6147075 |
Alkyl, azido, alkoxy and fluoro-substituted and fused quinoxalinediones
and the use thereof as glycine receptor antagonist |
8/18/99 |
11/14/00 |
|
6143773 |
Substituted thienobenzisoxazole derivatives for enhancing cognition |
4/22/99 |
11/7/00 |
|
6136832 |
5,5-disubstituted-3,4-dihydroxy-2(5H)-furanones and methods of
use therefor |
5/19/99 |
10/24/00 |
|
6136548 |
Methods for identifying useful T-PA mutant derivatives for treatment
of vascular hemorrhaging |
9/2/99 |
10/24/00 |
|
6133299 |
Methods for treating neurodegenerative diseases and disorders
using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other
anticonvulsant compounds |
2/25/93 |
10/17/00 |
|
6130234 |
4-substituted piperidine analogs and their use as subtype selective
NMDA receptor antagonists |
12/20/96 |
10/10/00 |
|
6124456 |
Pyrazolopyridine compound and pharmaceutical use thereof |
1/19/99 |
9/26/00 |
|
6124317 |
2-substituted piperidine analogs and their use as subtype-selective
NMDA receptor antagonists |
11/18/98 |
9/26/00 |
|
6114132 |
Prosphatase binding assay |
11/4/97 |
9/5/00 |
|
6117901 |
N-(aryl/heteroarylacetyl) amino
acid esters, pharmaceutical compositions comprising same, and
methods for use |
11/21/97 |
9/12/00 |
|
6110911 |
Cyclic amine derivatives of substituted
quinoxaline 2,3-diones as glutamate receptor antagonists |
3/19/99 |
8/29/00 |
|
6107305 |
Use of pyrazolo [3,4-b] pyridine
as cyclin dependent kinase inhibitors |
12/11/98 |
8/22/00 |
|
6103910 |
D-proline derivatives |
10/27/98 |
8/15/00 |
|
6103882 |
Method of producing a 19P2 ligand |
6/26/98 |
8/15/00 |
|
6096771 |
Isoxazole derivatives |
2/3/99 |
8/1/00 |
|
6096744 |
Sulfonamide derivatives of substituted quinoxaline 2,3-diones
as glutamate receptor antagonists |
5/4/98 |
8/1/00 |
|
6093720 |
Trans apovincaminic acid ester derivatives |
6/9/98 |
7/25/00 |
|
6090808 |
Dimeric piperidine, tetrahydropyridine and piperazine derivatives |
5/6/98 |
7/18/00 |
|
6075026 |
Certain substituted 1-aryl-3-piperazin-1'-yl propanones |
4/21/97 |
6/13/00 |
|
6071709 |
Nerve growth factor/receptor complex |
5/29/92 |
6/6/00 |
|
6068990 |
Proteins, their production and use |
9/18/98 |
5/30/00 |
|
6057349 |
2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives
of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides
and ureas and their use |
3/8/99 |
5/2/00 |
|
6046213 |
Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol
derivatives |
2/13/97 |
4/4/00 |
|
6046203 |
Substituted 3-(aminoalklamino)-1,2-benzisoxazoles and related
compounds |
6/6/95 |
4/4/00 |
|
6022683 |
Methods for assessing the prognosis of a patient with a neurodegenerative
disease |
12/16/96 |
2/8/00 |
|
6018024 |
Methods and compositions for monitoring cellular processing of
beta-amyloid precursor protein |
5/1/97 |
1/25/00 |
|
6017963 |
Naphthylazo inhibition of amyloidosis |
5/3/99 |
1/25/00 |
|
6010878
|
Interleukin-1 .beta. converting enzyme like apoptotic protease-6 |
5/8/97 |
1/4/00 |
|
6010854 |
Autoantibodies to neurotransmitter receptors |
7/3/97 |
1/4/00 |
|
6008217 |
Inhibitors of interleukin-1.beta. converting enzyme |
12/20/95 |
12/28/99 |
|
6008042 |
Interleukin-1 beta converting enzyme like apoptotic protease-7 |
5/7/97 |
12/28/99 |
|
6008024 |
Monoclonal antibodies specific for PHF-tau, hybridomas secreting
them, antigen recognition by these antibodies and their applications |
6/20/96 |
12/28/99 |
|
6005000 |
5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods
of use therefor |
8/20/97 |
12/21/99 |
|
6001970 |
Modified human neuropeptide Y1 Receptors |
5/6/97 |
12/14/99 |
|
6001814 |
Serine protease inhibitors |
6/3/98 |
12/14/99 |
|
6001813 |
Val-pro containing a-keto oxadiazoles as serine protease
inhibitors |
6/3/98 |
12/14/99 |
|
5998460 |
Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N1-benzylnoreseroline:
selective inhibitors of acetyl and butyrylcholinesterase, pharmaceutical
compositions and method of use thereof |
7/26/93 |
12/7/99 |
|
5998460 |
Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N1-benzylnoreseroline:
selective inhibitors of acetyl and butyrylcholinesterase, pharmaceutical
compositions and method of use thereof |
7/26/93 |
12/7/99 |
|
5990126 |
Quinolinic sulfide derivatives acting as NMDA receptor antagonists
and process for preparation thereof |
3/31/98 |
11/23/99 |
|
5990078 |
Means of increasing estrogen receptor levels in neural tissue |
7/12/96 |
11/23/99 |
|
5981195 |
Chimeric receptors and methods for identifying compounds active
at metabotropic glutamate receptors |
7/25/96 |
11/9/99 |
|
5981193 |
Human neuronal nicotinic acetylcholine receptor compositions
and methods employing same |
11/30/92 |
11/9/99 |
|
5981168 |
Method and composition for modulating amyloidosis |
5/15/98 |
11/9/99 |
|
5932596 |
Imidazoylalkyl substituted with a six membered nitrogen containing
nitrogen containing heterocyclic ring |
6/1/95 |
8/3/99 |
|
5910443 |
Medium for culturing human olfactory neurons |
9/25/92 |
6/8/99 |
|
5876948 |
Screening methods to identify neurotoxin inhibitors |
7/29/91 |
3/2/99 |
|
5871712 |
Methods for detecting calpain activation and identifying calpain
inhibitors |
1/26/96 |
2/16/99 |
|
5869336 |
Recombinant enzymatically active calpain expressed in a baculovirus
system |
7/17/ |
2/9/99 |
|
5866318 |
Inhibition of phospholipase A2 to reduce neuronal cell death |
6/7/95 |
2/2/99 |
|
5858326 |
Methods of increasing amyloid deposition |
6/6/95 |
1/12/99 |
|
5856169 |
Isoforms of human interleukin-1.beta. converting enzyme and methods
of using the same |
2/21/95 |
1/5/99 |
|
5852053 |
Use of 2-4-amino-4-(4-fluorobenzylamino) (-1-ethoxy-carbonylaminobenzene
for the prophylaxis and treatment of the neurodegenerative disorders |
10/28/96 |
12/22/98 |
|
5849988 |
Rat comprising straight filaments in its brain |
6/17/94 |
12/15/98 |
|
5837672 |
Methods and compositions for the detection of soluble .beta.-amyloid
peptide |
6/1/95 |
11/17/98 |
|
5837479 |
Screening assays for inhibitors of mammalian prostaglandin H
synthase-2 |
6/7/95 |
11/17/98 |
|
5837473 |
Methods of screening for agents affecting the deposition of .beta.-amyloid
peptides on amyloid plaques in human tissue |
5/3/95 |
11/17/98 |
|
5834244 |
Factor VIIa inhibitors from Kunitz domain proteins |
3/3/95 |
11/10/98 |
|
5817626 |
Modulators of beta-amyloid peptide aggregation |
3/14/95 |
10/6/98 |
|
5811243 |
Methods and compositions for binding tau and MAP2c proteins |
10/25/96 |
9/22/98 |
|
5807999 |
Monoclonal antibody that distinguishes between phosphorylated
and nonphosphorylated histone H1 and uses therefor |
2/1/93 |
9/15/98 |
|
5804560 |
Peptide and peptide analog protease inhibitors |
1/6/95 |
9/8/98 |
|
5801184 |
Carbon monoxide dependent guanylyl cyclase modifiers and methods
of use |
6/8/95 |
9/1/98 |
|
5780587 |
Compounds and methods for inhibiting .beta.-protein filament
formation and neurotoxicity |
4/6/95 |
7/14/98 |
|
5773219 |
Process for detecting Alzheimer disease using cultured cells |
3/8/96 |
6/30/98 |
|
5750374 |
Process for producing hydrophobic polypeptides and proteins,
and fusion proteins for use in producing same |
6/29/94 |
5/12/98 |
|
5744368 |
Methods for the detection of soluble amyloid beta.-protein or
soluble transthyretin (TTR) |
11/4/93 |
4/28/98 |
|
5733734 |
Method of screening for Alzheimer's disease or disease associated
with the accumulation of paired helical filaments |
10/29/93 |
3/31/98 |
|
5723301 |
Method to screen compounds that affect GAPDH binding to polyglutamine |
11/3/95 |
3/3/98 |
|
5721130 |
Antibodies and fragments thereof which bind the carboxyl-terminus
of an amino-terminal fragment of .beta.APP |
5/12/95 |
2/24/98 |
|
5721106 |
In Vitro method for screening .beta.-amyloid deposition |
9/12/94 |
2/24/98 |
|
5714471 |
Peptide and peptide analog protease inhibitors |
5/17/95 |
2/3/98 |
|
5670634 |
Reversal of .beta./A4 amyloid peptide induced morphological changes
in neuronal cells by antisense oligonucleotides |
6/1/95 |
9/23/97 |
|
5656477 |
Amyloid precursor proteins and method of using same to assess
agents which down-regulate formation of .beta.-amyloid peptide |
9/20/93 |
8/12/97 |
|
5643726 |
Methods for modulating transcription from the amyloid beta.-protein
precursor (APP) promoter |
11/10/94 |
7/1/97 |
|
5605811 |
Methods and compositions for monitoring cellular processing of
beta-amyloid precursor protein |
5/12/95 |
2/25/97 |
|
5593846 |
Methods for the detection of soluble .beta.-amyloid peptide |
5/9/95 |
1/14/97 |
|
5550216 |
Gelatinase A inhibitor, and analytical reagent thereof for the
determination of gelatinase A |
4/25/94 |
8/27/96 |
|
5547841 |
In vitro method for screening for drugs that inhibit production
or degradation of human A4-amyloid |
12/15/92 |
8/20/96 |
|
5536639 |
Methods for detecting calpain activation by detection of calpain
activated spectrin breakdown products |
3/25/94 |
7/16/96 |
|
5506097 |
Method for inhibiting .beta.-protein enzymatic activity |
1/10/94 |
4/9/96 |
|
5459051 |
Methods and vectors for over-expression of ubiquitin fusion proteins
in host cells |
8/2/93 |
10/17/95 |
|
5441870 |
Methods for monitoring cellular processing of ß-amyloid
precursor protein |
10/26/92 |
8/15/95 |
|
5361763 |
Method for segmenting features in an image |
3/2/93 |
11/8/94 |
|
5348963 |
Method of screening for modulators of amyloid formation |
5/26/93 |
9/20/94 |
|
5338663 |
Method of identifying inhibitors of .beta.-protein esterase activity |
1/13/92 |
8/16/94 |
|
5262945 |
Method for quantification of brain volume from magnetic resonance
images |
8/9/91 |
11/16/93 |
|
5221607 |
Assays and reagents for amyloid deposition |
10/29/91 |
6/22/93 |
|
5214031 |
Growth-inhibitory factor obtained from human brain |
5/6/91 |
5/25/93 |
|
5200339 |
Proteases causing abnormal degradation of amyloid ß-protein
precursor |
4/5/91 |
4/6/93 |
|
5017375 |
Method to prepare a neurotrophic composition |
5/18/87 |
5/21/91 |
|
4816416 |
Microspheric bodies for use in screening therapies for Azheimer's
disease and related conditions |
3/3/87 |
3/28/89 |
Home
