| 6509515 |
Transgenic mice expressing mutant human APP and forming congo red staining plaques |
3/2/99 |
1/21/03 |
| 6509333 |
Lactams substituted by cyclic succinates as inhibitors of A-β protein production |
6/1/01 |
1/21/03 |
| 6500820 |
Pharmaceutical composition for neurotrophic action |
10/10/00 |
12/31/02 |
| 6495540 |
Lactams as inhibitors of A-β protein production |
3/27/01 |
12/17/02 |
| 6489459 |
Identification of HOP-1 and uses thereof |
9/25/97 |
12/3/02 |
| 6476263 |
Compounds for inhibiting β-amyloid peptide release and/or its synthesis |
4/3/01 |
11/5/02 |
| 6468791 |
Chromosome 1 gene and gene products related to Alzheimer's Disease |
8/16/99 |
10/22/02 |
| 6452065 |
Transgenic mouse expressing non-native wild-type and familial Alzheimer's Disease mutant presenilin 1 protein on native presenilin 1 null background |
5/14/98 |
9/17/02 |
| 6440967 |
Combination of a GABAA alpha 5 inverse agonist and COX-2 inhibitor, NSAID, estrogen or vitamin E |
11/10/99 |
8/27/02 |
| 6440698 |
Alzheimer's disease secretase, APP substrates therefor, and uses therefor |
4/12/00 |
8/27/02 |
| 897545 |
Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
7/2/01 |
8/13/02 |
| 6420534 |
Alzheimer's disease secretase, APP substrates therefor, and uses thereof |
4/12/00 |
7/16/02 |
| 6420404 |
Use of amino-isoxazolidone compounds for improvement of implicit memory |
2/26/01 |
7/16/02 |
| 6395960 |
Transgenic mice expressing human presenilin proteins |
7/29/98 |
5/28/02 |
| 6391914 |
Optically active aminopentane derivatives |
6/16/00 |
5/21/02 |
| 6387674 |
Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions |
7/28/98 |
5/14/02 |
| 6387674 |
Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions |
7/28/98 |
5/14/02 |
| 6383758 |
Alzheimer's related proteins and methods of use |
1/8/99 |
5/7/02 |
| 6369052 |
Combination of huperzine and nicotinic compounds as a neuroprotective agent |
7/23/01 |
4/9/02 |
| 6359112 |
Peptides used as agonists and/or inhibitors of amyloid formation and
cytotoxicity and also for use in alzheimer's disease, in type II diabetes
mellitus and in spongiform encephalophathies |
6/12/98 |
3/19/02 |
|
6358945 |
Compounds useful as anti-inflammatory agents |
2/16/00 |
3/19/02 |
|
6340783 |
Rodent models of human amyloidoses |
10/3/96 |
1/22/02 |
|
6333317 |
Regulation of amyloid precursor protein (APP) expression by administration
of an estrogenic compound |
3/27/98 |
12/25/01 |
|
6331408 |
Use of small molecule radioligands to discover inhibitors of
amyloid-beta peptide production |
11/12/99 |
12/18/01 |
|
6313268 |
Secretases related to Alzheimer's dementia |
4/20/99 |
11/6/01 |
|
6310197 |
Translation enhancer element of the human amyloid precursor protein
gene |
11/9/98 |
10/30/01 |
|
6306857 |
Methods for treating or preventing alzheimer's disease using
substituted 1-aryl-3-piperazin-1'-yl propanones |
8/10/99 |
10/23/01 |
|
6303638 |
Substituted pyridines as modulators of the mammalian neuronal
nicotinic acetylcholine receptor |
8/20/99 |
10/16/01 |
|
6303576 |
Compounds and methods for modulating .beta.-catenin mediated
gene expression |
4/21/99 |
10/16/01 |
|
6300540 |
Transgenic mouse expressing an APP-FAD DNA sequence |
6/5/95 |
10/9/01 |
|
6300539 |
Model for chronic cerebral inflammation by intracerebral injection
of double stranded RNA |
12/30/99 |
10/9/01 |
|
6294346 |
Use of multipotent neural stem cells and their progeny for the
screening of drugs and other biological agents |
6/7/95 |
9/25/01 |
|
6264943 |
Method for transplanting cells into the brain and therapeutic
uses therefor |
12/10/99 |
7/24/01 |
|
6255054 |
Polymorphism of the human GluR-5 gene and risk factor for alzheimer
disease |
9/9/99 |
7/3/01 |
|
6248559 |
Gene encoding human tau-protein kinase I and use thereof |
12/21/98 |
6/19/01 |
|
6248555 |
Genetic alterations related to familial alzheimer's disease |
8/30/96 |
6/19/01 |
|
6245964 |
Transgenic rodent comprising APP-Swedish |
12/10/98 |
6/12/01 |
|
6245751 |
Methods for the treatment of apolipoprotein E related diseases |
9/10/99 |
6/12/01 |
|
6238892 |
Monoclonal antibodies directed against the microtubule-associated
protein tau |
3/15/96 |
5/29/01 |
|
6221645 |
.beta.-secretase antibody |
6/7/96 |
4/24/01 |
|
6218506 |
Amyloid .beta. protein (globular assembly and uses thereof) |
2/5/97 |
4/17/01 |
|
6211428 |
Transgenic mouse expressing a familial form of human amyloid
precursor protein |
4/28/97 |
4/3/01 |
|
6211235 |
Compounds for inhibiting .beta.-amyloid peptide release and/or
its synthesis |
9/30/98 |
4/3/01 |
|
6210919 |
Genetic sequences and proteins related to alzheimer's disease |
6/28/95 |
4/3/01 |
|
6207803 |
Human requiem |
1/19/99 |
3/27/01 |
|
6207710 |
Compounds for inhibiting .beta.-amyloid peptide release and/or
its synthesis |
9/30/98 |
3/27/01 |
|
6194153 |
Methods for determining risk of developing alzheimer's disease
by detecting mutations in the presenilin 1 (PS-1) gene |
7/31/98 |
2/27/01 |
|
6191166 |
Methods and compounds for inhibiting .beta.-amyloid peptide release
and/or its synthesis |
11/21/97 |
2/20/01 |
|
6187992 |
Transgenic mouse having a disrupted amyloid precursor protein
gene |
3/11/99 |
2/13/01 |
|
6184435 |
Transgenic mouse expressing APP770-V717F |
6/7/95 |
2/6/01 |
|
6184350 |
Hippocampus-associated proteins, DNA sequences coding therefor
and uses thereof |
3/17/99 |
2/6/01 |
|
6184248 |
Compositions and methods for treatment of neurological disorders
and neurodegenerative diseases |
11/8/99 |
2/6/01 |
|
6177242 |
Genomic DNA fragments containing regulatory and coding sequences
for the .beta.2-subunit of the neuronal nicotinic acetylcholine
receptor and transgenic animals made using these fragments or
mutated fragments |
12/14/94 |
1/23/01 |
|
6175057 |
Transgenic mouse model of alzheimer's disease and cerebral amyloid
angiopathy |
10/8/97 |
1/16/01 |
|
6172277 |
Non-transgenic rodent model of alzheimer's disease |
10/28/97 |
1/9/01 |
|
6156311 |
Modulators of expression and function of LRP in alzheimer's disease |
7/26/96 |
12/5/00 |
|
6140309 |
Vasoactive effects and free radical generation by .beta.-amyloid
peptides |
3/12/96 |
10/31/00 |
|
6133276 |
Compounds and methods for increasing endogenous levels of corticotropin-releasing
factor |
12/29/98 |
10/17/00 |
|
6126918 |
Screening assays to identify therapeutic agents for amyloidosis |
8/22/96 |
10/3/00 |
|
6117978 |
Presenilin-2 and mutations thereof |
7/29/98 |
9/12/00 |
|
6117901 |
N-(aryl/heteroarylacetyl) amino
acid esters, pharmaceutical compositions comprising same, and
methods for use |
11/21/97 |
9/12/00 |
|
6096782 |
N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions
comprising same and methods for inhibiting .beta.-amyloid peptide
release and/or its synthesis by use of such compounds |
11/21/97 |
8/1/00 |
|
6093397 |
Amyloid precursor protein protease |
10/2/97 |
7/25/00 |
|
6087153 |
Sel-10 and uses thereof |
7/24/97 |
7/11/00 |
|
6083920 |
Compositions for modulating intracellular inositol trisphosphate
concentration |
12/20/96 |
7/4/00 |
|
6083713 |
Cloning and expression of .beta.APP-C100 receptor (C100-R) |
11/15/95 |
7/4/00 |
|
6080778 |
Methods for decreasing beta amyloid protein |
3/23/98 |
6/27/00 |
|
6068990 |
Proteins, their production and use |
9/18/98 |
5/30/00 |
|
6066636 |
Muscarinic antagonists |
6/28/99 |
5/23/00 |
|
6057286 |
Identification and use of selective inhibitors of glycogen synthase
kinase 3 |
4/2/97 |
5/2/00 |
|
6057117 |
Identification and use of selective inhibitors of glycogen synthase
kinase 3 |
3/12/99 |
5/2/00 |
|
6054114 |
Organometallic ligands for the localization and quantification
of amyloid in vivo and in vitro |
5/7/97 |
4/25/00 |
|
6043255 |
Muscarinic antagonists |
3/10/99 |
3/28/00 |
|
6037521 |
Transgenic mouse expressing an .beta.-Amyloid transgene |
11/14/94 |
3/14/00 |
|
6037352 |
Muscarinic antagonists |
11/19/98 |
3/14/00 |
|
6025183 |
Transgenic animal assay system for anti-cholinesterase substances |
3/6/97 |
2/15/00 |
|
6020143 |
Method for identifying substances that affect the interaction
of a presenilin-1-interacting protein with a mammalian presenilin-1
protein |
7/3/97 |
2/1/00 |
|
6011019 |
Vasoactive effects and free radical generation by .beta.-amyloid
peptides |
11/12/96 |
1/4/00 |
|
6010874 |
Early onset alzheimer's disease gene and gene products |
6/26/96 |
1/4/00 |
|
6001970
|
Modified human neuropeptide Y1 Receptors |
5/6/97 |
12/14/99 |
|
5986054 |
Genetic sequences and proteins related to alzheimer's disease |
1/26/96 |
11/16/99 |
|
5977138 |
Ether muscarinic antagonists |
8/13/97 |
11/2/99 |
|
5977131 |
Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor
binding agents |
3/31/98 |
11/2/99 |
|
5932780 |
Transgenic non-human animal assay system for anti-cholinesterase
substances |
1/9/95 |
8/3/99 |
|
5912410 |
Transgenic non-human mice displaying the amyloid-forming pathology
of alzheimer's disease |
4/13/95 |
6/15/99 |
|
5898094 |
Transgenic mice expressing APPK670N,M671L and a mutant presenilin
transgenes |
7/30/97 |
4/27/99 |
|
5894078 |
Transgenic mouse expressing C-100 app |
2/26/96 |
4/13/99 |
|
5891991 |
Amyloid precursor-like protein and uses thereof |
8/6/96 |
4/6/99 |
|
5885800 |
DNA encoding tumor necrosis related receptor, TR4 |
2/4/97 |
3/23/99 |
|
5877015 |
APP770 mutant in alzheimer's disease |
1/21/92 |
3/2/99 |
|
5877399 |
Transgenic mice expressing APP-Swedish mutation develop progressive
neurologic disease |
6/17/96 |
3/2/99 |
|
5874277 |
Proteins, their production and use |
4/4/97 |
2/23/99 |
|
5869336 |
Recombinant enzymatically active calpain expressed in a baculovirus
system |
7/17/97 |
2/9/99 |
|
5856169 |
Isoforms of human interleukin-1.beta. converting enzyme and methods
of using the same |
2/21/95 |
1/5/99 |
|
5851787 |
Nucleic acid encoding amyloid precursor-like protein and uses
thereof |
1/21/93 |
12/22/98 |
|
5850003 |
Transgenic rodents harboring APP allele having swedish mutation |
1/22/97 |
12/15/98 |
|
5849999 |
Transgenic non-human mice expressing Flag-APP-C100 protein develop
alzheimer's disease brain morphology and behavior |
10/16/96 |
12/15/98 |
|
5840540 |
Nucleic acids encoding presenilin II |
11/10/97 |
11/24/98 |
|
5837841 |
Human Reg protein |
10/11/96 |
11/17/98 |
|
5811633 |
Transgenic mouse expressing APP.sub.770 |
6/7/95 |
9/22/98 |
|
5801184 |
Carbon monoxide dependent guanylyl cyclase modifiers and methods
of use |
6/8/95 |
9/1/98 |
|
5795963 |
Amyloid precursor protein in alzheimer's disease |
3/13/97 |
8/18/98 |
|
5777194 |
Gene-targeted mice with humanized A.beta. sequence and Swedish
FAD mutation |
4/23/96 |
7/7/98 |
|
5767248 |
Apolipoprotein E isoform-specific monoclonal antibodies |
4/8/97 |
6/16/98 |
|
5720936 |
Transgenic mouse assay for compounds affecting amyloid protein
processing |
7/29/94 |
2/24/98 |
|
5716828 |
Kit for detecting the ApoE4 allele, and for diagnosing the existence
or risk of developing Alzheimer's disease |
5/15/95 |
2/10/98 |
|
5670634 |
Reversal of .beta./A4 amyloid peptide induced morphological changes
in neuronal cells by antisense oligonucleotides |
6/1/95 |
9/23/97 |
|
5563048 |
Human stromal derived factor 1.alpha. and 1.beta., and DNAs encoding
the same |
10/14/94 |
10/8/96 |
|
5643726 |
Methods for modulating transcription from the amyloid beta.-protein
precursor (APP) promoter |
11/10/94 |
7/1/97 |
|
5612486 |
Transgenic animals harboring APP allele having swedish mutation |
11/1/93 |
3/18/97 |
|
5604131 |
cDNA-genomic DNA hybrid sequence encoding APP770 containing a
genomic DNA insert of the KI and OX-2 regions |
9/17/93 |
2/18/97 |
|
5854392 |
ß APP-C100 receptor |
8/30/93 |
12/29/98 |
|
5501979 |
Herpes simplex virus type I expression vector |
11/30/93 |
3/26/96 |
|
5489514 |
DNA coding for growth-inhibitory factor and use thereof |
8/28/92 |
2/6/96 |
|
5449604 |
Chromosome 14 and familial Alzheimers disease genetic markers
and assays |
10/21/92 |
9/12/95 |
|
5387742 |
Transgenic mice displaying the amyloid-forming pathology of alzheimer's
disease |
6/17/91 |
2/7/95 |
|
5218100 |
DNA encoding for the precursor protein of APC polypeptide associated
with Alzheimer's disease |
1/15/88 |
6/8/93 |
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