Important Notice: We are striving to include as many patents as possible, but we do not make a claim to being comprehensive. We may inadvertently omit certain patents due to a lack of information. If you notice an omission, please contact junekino@alzforum.org.

Patent Number	Description	Date Filed in US	Date Issued
6518011	Method for screening compounds to identify b-amyloid production modulators	1/12/00	2/11/03
6498017	Method for measuring the association of substructures of pathological protein depositions	5/22/00	12/24/02
6495335	Compositions and methods for diagnosing alzheimer's disease	12/7/00	12/17/02
6485911	Methods for determining risk of developing alzheimer's disease by detecting mutations in the presenilin 2 (PS-2) gene	8/11/00	11/26/02
6475161	Methods for diagnosing Alzheimer's disease and other forms of dementia	3/29/01	11/5/02
6472140	a-2- macroglobulin therapies and drug screening methods for Alzheimer's disease	2/2/99	10/29/02
6465195	Predictive diagnostic for Alzheimer's disease	12/29/00	10/15/02
6461831	Diagnostic test for alzheimer's disease	9/21/00	10/8/02
6458549	Methods of diagnosing renal salt wasting syndrome and Alzheimer's disease and methods of treating the same	6/11/98	10/1/02
6455757	Transgenic mice expressing human APP and TGF-b demonstrate cerebrovascular amyloid deposits	3/4/99	9/24/02
6455494	Use of p97 and iron binding proteins as diagnostic and therapeutic agents	4/1/99	9/24/02
6451547	Process for differential diagnosis of Alzheimer's dementia and device therefor	4/25/01	9/17/02
6432643	Method of determining Alzheimer's disease risk using apolipoprotein E4 genotype analysis in combination with decreased estrogen levels	10/22/99	8/13/02
6417178	Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits	11/6/97	7/9/02
6410747	Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias	6/17/99	6/25/02
6391553	Method for diagnosing Alzheimer disease	3/16/00	5/21/02
6374130	Methods for tracking the progression of Alzheimer's disease identifying treatment using transgenic mice	4/6/00	4/16/02
6365414	Vitro system for determining formation of A-amyloid	8/26/94	4/2/02
6358681	Diagnostic methods for alzheimer's disease by detection of multiple mRNAs	10/30/98	3/19/02
6342350	a-2-macroglobulin diagnostic test	9/4/98	1/29/02
6329531	Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infrared radiation (NIR radiation)	11/18/99	12/11/01
6329155	Methods of identifying agents which regulate release of amyloid precursor protein	4/5/94	12/11/01
6306086	Memory tests using item-specific weighted memory measurements and uses thereof	8/6/99	10/23/01
6300085	Diagnostic method for Alzheimer's disease	7/18/97	10/9/01
6287793	Diagnostic methods for alzheimer's disease	3/12/92	9/11/01
6245575	Screening of agents for treatment of alzheimer's disease	7/16/99	6/12/01
6225069	Methods to identify genetic predisposition to alzheimer's disease	2/29/00	5/1/01
6223074	Method and computer program product for assessing neurological conditions and treatments using evoked response potentials	9/28/99	4/24/01
6214569	Methods for screening for inhibitors of Alzheimer b-peptide filament formation	8/19/97	4/10/01
6210970	Method of diagnosing or categorizing disorders from biochemical profiles	7/16/93	4/3/01
6210895	Ho-1 as a diagnostic and prognostic test for dementing diseases	6/1/99	4/3/01
6200768	Method of screening for compounds that dissolve paired helical filaments	11/28/94	3/13/01
6194217	Method of diagnosing or categorizing disorders from biochemical profiles	8/12/93	2/27/01
6194153	Methods for determining risk of developing alzheimer's disease by detecting mutations in the presenilin 1 (PS-1) gene	7/31/98	2/27/01
6183981	Diagnostic assay for late-onset Alzheimer's disease	3/4/99	2/6/01
6162186	Non-invasive method for diagnosing alzheimer's disease in a patient	11/9/99	12/19/00
6136530	Compositions and methods for assessing risk factors in Alzheimer's disease	11/27/96	10/24/00
6132977	Measurement of a CNS protein in cerebrospinal or amniotic fluid	3/13/98	10/17/00
6130048	Method of diagnosing Alzheimer's disease	11/10/97	10/10/00
6114175	Compound for the antemortem diagnosis of Alzheimer's Disease and in vivo imaging and prevention of amyloid deposition	11/9/98	9/5/00
6114133	Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-b peptide (x-.gtoreq.41)	11/14/94	9/5/00
6107050	Diagnostic test for alzheimers disease	5/11/98	8/22/00
6096302	Assay for the measurement of neuronal degradation and uses thereof	10/4/96	8/1/00
6087118	Method for diagnosing alzheimer's disease	3/4/99	7/11/00
6083694	Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the alzheimer's S182 gene	10/25/96	7/4/00
6080582	Cell tests for Alzheimer's disease	5/15/98	6/27/00
6071705	Method of detecting neurological disease or dysfunction	6/6/95	6/6/00
6067986	Method and apparatus employing motor measures for early diagnosis and staging of dementia	10/29/93	5/30/00
6027899	Method for determining propensity for developing late-onset Alzheimer's disease	9/9/98	2/22/00
6027896	Methods of detecting Alzheimer's disease	4/15/98	2/22/00
6024707	Non-invasive method for diagnosing Alzheimer's disease in a patient	9/17/97	2/15/00
6022683	Methods for assessing the prognosis of a patient with a neurodegenerative disease	12/16/96	2/8/00
6001331	Method of imaging amyloid deposits	7/22/98	12/14/99
5994084	Models of Alzheimer's disease	8/23/96	11/30/99
5985581	Use of presenilin-1 for diagnosis of alzheimer's disease	7/17/97	11/16/99
5985564	Assay for identifying agents that inhibit chromosome non-disjunction	8/8/97	11/16/99
5981208	Diagnostic assay for Alzheimer's disease based on the proteolysis of the amyloid precursor protein	10/6/94	11/9/99
5981194	Use of p97 and iron binding proteins as diagnostic and therapeutic agents	8/31/95	11/9/99
5976817	Diagnostic method for detecting Alzheimer's disease in living patients	10/31/96	11/2/99
5976816	Cell tests for alzheimer's disease	9/26/94	11/2/99
5965614	N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting b-amyloid peptide release and/or its synthesis by use of such compounds	11/21/97	10/12/99
5942400	Assays for detecting b-secretase	6/7/96	8/24/99
5879883	Method for screening for alzheimer's disease	5/3/95	3/9/99
5874312	Diagnosis of alzheimer disease stage by mononuclear cell cytokine secretions	1/10/97	2/23/99
5871712	Methods for detecting calpain activation and identifying calpain inhibitors	1/26/96	2/16/99
5849600	Diagnostic assays for Alzheimer's disease	11/10/93	12/15/98
5833988	Transferrin receptor specific antibody- neuropharmaceutical or diagnostic agent conjugates	4/18/96	11/10/98
5830670	Neural thread protein gene expression and detection of Alzheimer's disease	5/30/95	11/3/98
5826585	Method for diagnosis of incontinence of corticocerebral origin by neurologic examination	5/24/96	10/27/98
5807999	Monoclonal antibody that distinguishes between phosphorylated and nonphosphorylated histone H1 and uses therefor	2/1/93	9/15/98
5778893	Method of diagnosing and monitoring a treatment for Alzheimer's disease	5/19/95	7/14/98
5773219	Process for detecting Alzheimer disease using cultured cells	3/8/96	6/30/98
5767248	Apolipoprotein E isoform-specific monoclonal antibodies	4/8/97	6/16/98
5766846	Methods of screening for compounds which inhibit soluble b-amyloid peptide production	6/17/93	6/16/98
5744368	Methods for the detection of soluble amyloid b-protein or soluble transthyretin (TTR)	11/4/93	4/28/98
5733734	Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments	10/29/93	3/31/98
5721243	Radiopharmaceutical agents for the detection of Alzheimers disease	6/13/94	2/24/98
5721106	In Vitro method for screening b-amyloid deposition	9/12/94	2/24/98
5716828	Kit for detecting the ApoE4 allele, and for diagnosing the existence or risk of developing Alzheimer's disease	5/15/95	2/10/98
5704369	Non-invasive method for diagnosing Alzeheimer's disease in a patient	9/22/95	1/6/98
5705401	Method of assaying for alzheimer's disease	9/16/94	1/6/98
5693478	Method of detecting amyloid precursor proteins	6/5/95	12/2/97
5686269	Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in CSF	7/28/94	11/11/97
5631168	Antemortem diagnostic test for Alzheimer's disease	12/12/94	5/20/97
5624807	Methods for detecting Alzheimer's disease by measuring ratios of calcium-activated neutral protease isoforms	1/24/94	4/29/97
5617861	Magnetic resonance spectral analysis of the brain for diagnosis of clinical conditions	2/16/94	4/8/97
5604102	Methods of screening for ß-amyloid peptide production inhibitors	10/27/93	2/18/97
5593846	Methods for the detection of soluble b-amyloid peptide	5/9/95	1/14/97
5580748	Diagnostic tests for alzheimers disease	5/3/93	12/3/96
5571671	Method for detecting Alzheimer's disease	3/23/94	11/5/96
5545566	Antemortem diagnostic test for alzheimer's disease	6/5/95	8/13/96
5536639	Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products	3/25/94	7/16/96
5535760	Method for detecting and treating Alzheimer's disease	3/24/95	7/16/96
5525339	Isolated components of dense microspheres derived from mammalian brain tissue and antibodies thereto	12/17/93	6/11/96
5508167	Methods of screening for Alzheimer's disease	4/13/94	4/16/96
5492812	Diagnostic method for Alzheimer's disease by screening for tau-peptides in the blood of a patient	11/30/93	2/20/96
5449604	Chromosome 14 and familial Alzheimers disease genetic markers and assays	10/21/92	9/12/95
5445937	Detection of Alzheimer's disease and other diseases using an improved photoaffinity labeling method	10/20/93	8/29/95
5309923	Method and apparatus for determining brain activity including the nature of brain lesions by electroencephalography	8/12/92	5/10/94
5269315	Determining the nature of brain lesions by electroencephalography	8/16/91	12/14/93
5262332	Diagnostic method for Alzheimer's disease: examination of non-neural tissue	9/19/89	11/16/93
5234814	Diagnostic assay for alzheimer's disease	6/1/89	8/10/93
5230346	Diagnosing brain conditions by quantitative electroencephalography	2/4/92	7/27/93
5221607	Assays and reagents for amyloid deposition	10/29/91	6/22/93
5200324	Method of diagnosing senile dementia of the Alzheimer type	8/1/91	4/6/93
5134062	Diagnosis of neuronal disorders and screening potential therapeutic agents therefor	3/22/88	7/28/92
5109868	Method for diagnosing senile dementia of the Alzheimer's type	3/18/91	5/5/92
5082446	Method for the assessment of severe dementia	6/12/90	1/21/92
5015570	Molecular diagnosis of Alzheimer Disease	5/13/88	5/14/91
4939124	Treatment and diagnosis of dementia	1/26/88	7/3/90
4874694	Use of phosphoprotein patterns for diagnosis of neurological and psychiatric disorders	4/7/87	10/17/89
4728605	Methods for recognizing and diagnosing subsets of Alzheimer's disease associated with immune system dysfunction, and for the in vitro testing of possible therapeutic agents for treatment of same	7/31/1984	3/1/88
4701407	Diagnosis of Alzheimer disease	8/23/85	10/20/87
4699875	Diagnosis of amyotrophic lateral sclerosis by neurotrophic factors	8/23/85	10/13/87
4666829	Polypeptide marker for Alzheimer's disease and its use for diagnosis	5/15/85	5/19/87

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