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DIHYDROLIPOAMIDE S-SUCCINYLTRANSFERASE (DLST). Gene Map Locus: 14q24.3 [OMIM 126063]
DLSTs act by decarboxylating alpha-keto acids in mitochondria. It was a candidate gene for the chromosome 14-mapping familial AD gene.
Comment on DLST from John Blass (firstname.lastname@example.org)
Association of DLST with AD has now been reported from Japan, the USA,
and Sweden (cf Nakano et al, Lancet 1997; 350:1367-1368;Sheu et al Ann
Neurol 1999; 45: 48-53; Sheu et al, Neurology 1999; 52: 1505-1507; Sheu,
Lilius et al, Neurobiol Aging 1998; 19:S293). A single negative report,
from Japan, was of a series in which controls and AD patients were not
matched for age or sex (Kunugi et al, Lancet 1998;351:1584-1585). Thus,
DLST, a nuclear gene encoding a mitochondrial component, seems more
clearly linked to AD than just as a former candidate gene on chromosome
14q24.3. Indeed, preliminary evidence from studies in Sweden indicate
that DLST remains a candidate gene for the 50% or more of chromosome
14q24.3-linked familial AD which can not be attributed to PS1.