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Home: Research: Compendia: Genes: AlzGene
Overview of all published large-scale and genome-wide association studies in AD
Back Search Methods Disclaimer Credits
 Status: Updated 6 July 2008;  ** See Large Scale Study Methods **
Overview of all published large-scale and genome-wide association studies in AD
              AD Cases Normal Controls    
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Featured Genes Comment
 Caucasian
Coon, 2007
CCGWA Overlaps with
Reiman, 2007		 CL Affymetrix (500K)502,627 No 664
(55%)		N-82 + 7.7
(-)		422
(60%)		79 + 11
(-)
Grupe, 2006
CCCWA [chr. 10] Overlaps with
Grupe, 2007		 CL Celera (cSNPs)1,412 No 1779
(-)		M--1754
(-)		-
Grupe, 2007
CCGWA USA & UK CL Celera (cSNPs)17,343 No 1808
(65%)		M75 + 6.7
(-)		-2062
(63%)		77.3 + 6.6
(-)
Li, 2006
CCCWA [chr. 9] Overlaps with
Grupe, 2007		 CL Celera (cSNPs)674 No 1703
(68%)		M75.9 + 6.3
(-)		-2106
(63%)		77.1 + 6.6
(-)
Li, 2007
CCGWA Canada CL Affymetrix (500K)469,438 Yes 753
(58%)		C71.9 + 8.5
(-)		77.8 + 8.6
(-)		736
(64%)		73.4 + 7.9
(-)
Li, 2008
* Recently Added *		CCLSA USA & UK CL Celera (cSNPs)4692 No 1652
(-)		C--1869
(-)		-
Reiman, 2007
CCGWA USA, Netherlands CL Affymetrix (500K)312,316 Yes 861
(-)		M-74.9 + 6.6
(-)		550
(-)		77.4 + 7.3
(-)
Use our Contact Form to alert us of discrepancies, errors in the representation of study details, or to notify us of your association study regarding this gene.
Design:  “CC” (case-control), “FBAT” (family-based)
Type:  “GWA” (genome-wide association study); “CWA” (chromosome-wide association study); “LSA” (other large-scale association study); “cSNP” (coding-region SNP)
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
Platform:  Please refer to orignal publication for exact description.
# SNPs:  Approximate number of polymorphisms covered.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine AD diagnosis -> "C" (clinical AD diagnosis), "N" (neuropathological AD diagnosis), "M" (mixed, i.e. AD sample contains both clinical and neuropathological cases), "U" (unknown).
Featured Genes:  Dropdown menu of genes highlighted (“featured”) in original publication as potential AD susceptibility genes/loci after completion of all analyses, e.g. replication in multiple samples.
(-) :  No information provided.
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