General Disclaimer

The overarching goal of this database is to serve as an unbiased, centralized, publicly available and regularly updated collection of genetic association studies performed on various Alzheimer disease (AD) phenotypes. To ensure the highest degree of objectivity regarding the posted information, only studies published or in press in peer-reviewed journals available in English are considered for inclusion into the database. Abstracts presented at scientific meetings or findings reported in non peer-reviewed publications are not considered for inclusion.

While we have made every possible effort to correctly represent the data of all studies fulfilling the above criteria, we cannot exclude the possibility that some studies are cited incorrectly or are erroneously excluded. However, we are not able to make any warranty, either expressed or implied, with respect to the functioning and accuracy of this database. No responsibility is assumed by the authors and curators.

To report an error in the data or to submit general concerns, comments, and suggestions about the database, please contact us. We encourage authors of original AD association studies either published or in press at a peer-reviewed scientific journal to send us your data.

Genome Screen Overview Disclaimer

Please note that the genome screen overview is only meant to provide a qualitative summary of the currently published full-genome screens in AD. The threshold criteria used for inclusion, as well as the fact that several studies have used overlapping AD populations could lead to a false-positive bias for some regions. Unfortunately, it is impossible to judge which of these "concordant" regions actually harbor genuine AD genes at this time. Furthermore, it cannot be excluded that chromosomes or chromosomal regions that do not appear in this overview actually contain relevant AD susceptibility genes. As soon as a meta-analysis—which should provide a more quantitative and unbiased summary—of these genome screens becomes available, it will replace the current qualitative overview table.

Meta-analyses Disclaimer

Please note that while the meta-analyses presented in this database take into account between-study heterogeneity, they do not consider potential confounding by publication bias, i.e., that the outcome/significance of any particular study directly influences its probability of publication. Thus, the gene-specific summary ORs presented in the meta-analysis section may be biased either upward or downward, depending on the publication probability for the particular gene or polymorphism.