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Home: Research: Compendia: Antibodies

Antibody Directory


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Antibodies to Tau-related Proteins
From the Laboratories
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
acetylated Tau /ac-tau (poly) IgG_2b	Ab708 Li Gan, Gladstone Institute of Neurological Disease Assistant Professor of Neurology University of California, San Francisco Reference: Min SW, 2010	immunogen = a synthetic tau peptide (amino acids 160–182 for 2N4R tau isoform) containing acetylated lysines at positions 163 and 174 and 180	polyclonal rabbit	WB	Ab708 specifically recognizes tau acetylated by p300 under cell-free conditions. In HEK293T cells transfected with tau, overexpression of p300 markedly elevated the levels of ac-tau detected with Ab708 while the increase in the levels of t-tau was modest, suggesting that Ab708 preferentially recognizes p300-induced ac-tau in cultured cells. Ab708 recognizes human tau acetylated at positions 163, 174, or 180 and possibly other acetylated lysines on tau, but not nonacetylated tau	human, rat
acetylated Tau /ac-tau (poly)	9AB Li Gan, Gladstone Institute of Neurological Disease Assistant Professor of Neurology University of California, San Francisco Reference: Min SW, 2010	immunogen = the microtubule-binding region aa 264–287 (ENLKHQPGGG VQIINKLDLSNV), which is 100% conserved between mouse and human	polyclonal rabbit	WB	9AB recognizes recombinant tau acetylated by GST-p300, but not tau incubated with GST alone, suggesting that 9AB does not cross-react with non-ac-tau. 9AB also preferentially recognizes p300-induced ac-tau in cultured cells. In mouse brains, 9AB detected low levels of ac-tau. Does not recognize nonacetylated recombinant tau	human, mouse
Tau (12E8)	anti-tau (12E8) (Peter Seubert, Elan Pharmaceuticals, South San Francisco, CA) References: Zempel H, 2010 van Eersel, 2010 Wang, 2009 Paquet, 2009 Planel, 2008 Eckermann, 2007 Wang, 2007 Roberson, 2007 Götz, 2001	immunogen = tau phosphorylated at S262, in KXGS motif of the 4th repeat, (KSKIGS_PTE NLKHQPG) and/or Ser356	monoclonal	IH	tau phosphorylated at S262, cross with S356	human, mammal (various) (reference Seubert P., et al., J Biol Chem. 270:18917, l995 Letersky et al, Biochem. J., 1996)
Tau (1E1/A6) IgG	anti-Tau RD4 (R. de Silva and T. Lashley, Reta Lila Weston Institute of Neurological Studies, Windeyer Building, London) Reference: Planel, 2008	peptide RS1 was designed to represent cognate regions for the 4R-tau isoforms. The RS1 sequence represents the most divergent domain	monoclonal mouse	IF, IH, WB; micro	specific responses to the three 4R-tau isoforms. No cross-reactivity was observed either at high recombinant protein concentrations or after prolonged exposure	(reference: deSilva R, Lashley T, et al. Neuropath & Applied Neurobio 29 (3):288, 2003)
Tau (8E6/C11) IgG	anti-Tau RD3 (R. de Silva and T. Lashley, Reta Lila Weston Institute of Neurological Studies, Windeyer Building, London) Reference: Planel, 2008	peptide RS3 was designed to represent cognate regions for the 3R-tau isoforms. The RS3 sequence represents the contiguous sequences at the junction of exons 9 and 11 in the absence of exon 10	monoclonal mouse	IF, IH, WB; micro	3R-tau. No cross-reactivity was observed either at high recombinant protein concentrations or after prolonged exposure	(reference: deSilva R, Lashley T, et al. Neuropath & Applied Neurobio 29 (3):288, 2003)
Tau (Alz50) IgM	Tau-004 (Peter Davies, Department of Pathology, Albert Einstein College of Medicine) References: Shahani, 2006 Tatebayashi, 2002 Lewis, 2001 Wittmann 2001		monoclonal mouse	IC, IF, IH, IP, WB	68 kDa Tau, homogenates of AD brain tissues. Stains neuronal components of AD brain specimens but not normal brain specimens.
Tau (Alz50) IgM	Tau-004 (Peter Davies, Department of Pathology, Albert Einstein College of Medicine) References: Shahani, 2006 Tanemura, 2006 Tatebayashi, 2002 Lewis, 2001 Wittmann 2001	(epitope at aa 5-15)	monoclonal mouse	IC, IF, IH, IP, WB	68 kDa Tau, homogenates of AD brain tissues. Stains neuronal components of AD brain specimens but not normal brain specimens.
Tau (CP27) IgG_2b	Peter Davies, Department of Pathology, Albert Einstein College of Medicine References: Vingtdeux, 2010 Herskovits, 2006 Duff, 2000		monoclonal mouse	WB	tau	human
Tau (CP9) IgG_2b	Peter Davies, Department of Pathology, Albert Einstein College of Medicine Reference: Roberson, 2007	epitope around phospho Threonine 231	monoclonal mouse	IB, IH	tau phospho. at Thr231	human, rat, mouse
Tau (DA9) IgG₁	Peter Davies, Department of Pathology, Albert Einstein College of Medicine Reference: Zempel H, 2010	epitope at aa102–140	monoclonal mouse	IH	recognizes total tau	human, mouse
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (MC1) IgG₁	Tau-001 (Peter Davies, Department of Pathology, Albert Einstein College of Medicine) References: Paquet, 2009 Eckermann, 2007 Shahani, 2006 Götz, 2001 Wittmann 2001	conformation dependent antibody (epitope within aa 312-322)	monoclonal mouse	IC, IF, IH, IP, WB	reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but does not react with FAC1	human, mouse
Tau (RTA-1)	(Taizo Taniguchi, Director Behavioral and Medical Science Research Consortium, Hyogo, Japan)	raised against human tau (epitope = first repeat of MBD, aa 257-274)	monoclonal mouse (supernate, gel filtered)	Block, EM	binds CHO-R3tau and CHO-R4tau; inhibits PHF formation in human tau, completly blocks in vitro 3RMBD and 4RMBD aggregation	(reference: Taniguchi T, Sumida M, et al., "Effects of different anti-tau antibodies on tau fibrillogenesis",FEBS Lett. 579(6):1399-404)
Tau (RTA-2)	(Taizo Taniguchi, Director Behavioral and Medical Science Research Consortium, Hyogo, Japan)	raised against human tau (epitope = second repeat of MBD, aa 273-283)	monoclonal mouse (supernate, gel filtered)	Block, EM	binds CHO-R4tau; inhibits PHF formation in human tau; completly blocks in vitro 4RMBD and partially inhibits 3RMBD aggregation	(reference: Taniguchi T, Sumida M, et al., "Effects of different anti-tau antibodies on tau fibrillogenesis",FEBS Lett. 579(6):1399-404)
Tau (RTA-C)	(Taizo Taniguchi, Director Behavioral and Medical Science Research Consortium, Hyogo, Japan)	raised against human tau (epitope = C terminal end, aa 426-441)	monoclonal mouse (supernate, gel filtered)	Block, EM	binds CHO-R3tau and CHO-R4tau; does not inhibit PHF formation	(reference: Taniguchi T, Sumida M, et al., "Effects of different anti-tau antibodies on tau fibrillogenesis",FEBS Lett. 579(6):1399-404)
Tau (T46)	anti-tau (Mawal-Dewan, Lankenau Institute for Medical Research, Wynnewood, PA) Reference: Ishihara 2001	(epitope = aa 395-432)	monoclonal		recognizes aa 395-432 on phosphate independent tau
Tau (T49)	anti-tau (Mawal-Dewan, Lankenau Institute for Medical Research, Wynnewood, PA) Reference: Ishihara 2001	immunogen = rodent tau	monoclonal		recognizes phosphate independent tau
Tau (Tau-1) IgG_2a	Tau-1 (L.I. Binder, Northwestern Univ.) Paper Reference: Alonso, 2010		monoclonal mouse	ELISA, WB	detects Tau that is not phosphorylized at at Ser198/Ser199/Ser202	rat, mouse
Tau (TG-3) IgM	Tau-003 (Peter Davies, Department of Pathology, Albert Einstein College of Medicine) References: Bhaskar K, 2010 Planel, 2008 Götz 2001 Lewis, 2001	(epitope around phosphor. Thr231); also sensitive to the conformation of the phosphor. tau	monoclonal mouse (IC, IF, IH, IP, WB)	conformation- dependent phospho epitopes on tau	tau phosphor. at Thr231; not reactive to normal tau; TG3 epitope (phosphorylated Thr231) is expressed in mitotic cells but not in quiescent cells, suggesting that mitotic phosphoepitopes may lead to conformational changes	human
Tau (TG-5) IgG_2b	Peter Davies, Department of Pathology, Albert Einstein College of Medicine References: Herskovits, 2006 Duff, 2000		monoclonal mouse		tau	human, mouse
Tau (poly)	anti-tau (Y. Ihara, Univ. of Tokyo) Reference:Tatebayashi 2002	immunogen = tau (AW406) and tau (AR406)	polyclonal	IH	recognizes mutant R406W and wild-type tau, AR406
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (poly)	Tau R145d (K Iqbal, New york State institute for Basic Research in Developmental Disabilities) Reference:Götz 2001	immunogen = tau derived peptide phosphorylated at Ser-422	polyclonal	WB	tau phosphorylated at Ser-422 see antibody	human, rat, mouse (Reference Tanaka T., Zhong J., Iqbal K., et al., FEBS Lett. 426:248, l998)
Tau (poly)	anti-Tau PS199 (Ishiguro Mitsubishi Kagaku Institute of Life Science, Tokyo, Japan) Reference:Tanemura, 2002	raised against tau phosphorylated Serine 199	polyclonal rabbit		recognizes tau phosphorylated at Serine 199	human (reference Michel G, Mercken M, ... Takashima A. Biochim Biophys Acta 1380:177-182, 1998)
Tau (poly)	anti-Tau PS396 (Ishiguro Mitsubishi Kagaku Institute of Life Science, Tokyo, Japan) Reference:Tanemura, 2002	raised against tau phosphorylated Serine 396	polyclonal rabbit		recognizes tau phosphorylated at Serine 396	human (reference Michel G, Mercken M, ... Takashima A. Biochim Biophys Acta 1380:177-182, 1998)
Tau (poly)	anti-Tau JM (Takashima Laboratory for Alzheimer's Disease, Brain Science Institute , Saitama 350-01, Japan) References: Yuan, 2008 Tanemura, 2002 Tanemura, 2006	raised against recombinant human tau	polyclonal rabbit	IP, WB	recognizes both phosphorylated and non phosphorylated tau	human, mouse (reference: Takashima, Murayama, ... Wolozin PNAS USA 95:9637-9641, 1998)
Tau (poly)	anti-Tau (Takashima Laboratory for Alzheimer's Disease, Brain Science Institute , Saitama 350-01, Japan) Reference: Tatebayashi 2002	immunogen = various phosphorylated tau	polyclonal	IH	antibodies PS199, PT205, PS396, PS404, PS413 and PS422 recognize tau phosphorylated at each corresponding site	(reference: Takashima, Murayama, ... Wolozin PNAS USA 95:9637-9641, 1998)
Tau (poly)	anti-Tau LK (Marc Merken McLean Hospital, Belmont, MA, Paper, 1995) Reference: Yuan, 2008	immunogen = affinity purified mouse tau	polyclonal rabbit	WB	LMW, MMW and HMW tau	mouse
Tau (poly)	BR134 (M Goedert, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England) Paper, Neuron. 1989 Oct;3(4):519-26 References Clavaguera, 2009	immunogen = synthetic peptide corresponding to amino acids 428–441 of tau	polyclonal	EM, IH	specific for carboxyl terminus of tau; phosphorylation independent	human
Tau (poly)	BR133 (M Goedert, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England) Paper, Neuron. 1989 Oct;3(4):519-26 References Clavaguera, 2009		polyclonal	EM, IH	specific for amino terminus of tau; phosphorylation independent	human
Tau (poly)	BR304 (M Goedert, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England) Paper, Neuron. 1989 Oct;3(4):519-26 References Clavaguera, 2009	immunogen includes amino acids 45–73 of human tau	polyclonal	IB, IH	specific for tau isoforms with one or two N‑terminal inserts (the amino-terminal 29- and 58-amino acid inserts of tau)	human
Tau (poly)	BR189 (M Goedert, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England) Paper, Neuron. 1989 Oct;3(4):519-26 References Clavaguera, 2009	immunogen includes amino acids 76-87 of human tau	polyclonal	IB, IH	specific for tau isoforms with two N‑terminal inserts (the amino-terminal 29- and 58-amino acid inserts of tau)	human
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (poly)	MT1 (M Goedert, Medical Research Council, Laboratory of Molecular Biology, Cambridge, England) Paper, J Neurosci. November 1, 2002 References Clavaguera, 2009	immunogen = synthetic peptide (ARVASKD RTGNDEK), residues 114-127 of the longest isoform of mouse brain tau	polyclonal rabbit	IB, IH	recognizes the three murine brain tau isoforms but fails to recognize human tau; phosphorylation independent; diffuse neuropil staining	mouse (not human)
Tau (poly)	111e (Khalid Iqbal, Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities) research Paper Reference: Alonso, 2010		polyclonal rabbit (antiserum)	WB	recognizes total tau and hyperphosphorylated tau from AD brain; no cross with bovine tau	human
Tau phos Ser202 (CP13) IgG_2b	Peter Davies, Department of Pathology, Albert Einstein College of Medicine References: Bhaskar K, 2010 Vingtdeux, 2010 Polydoro, 2009 Adams, 2009 Julien, 2008 Planel, 2008 Luo, 2007 Roberson, 2007 Herskovits, 2006	epitope around phospho-Serine 202	monoclonal mouse	WB	detects tau phosphor. at Serine 202	human
Tau phos Ser214 (CP3)	Peter Davies, Department of Pathology, Albert Einstein College of Medicine Paper, Jicha GA, et al., 1999 Reference: Vingtdeux, 2010	immunogen = amino acids around phosphorylated Ser214	monoclonal mouse	IH, WB	recognizes human and murine tau phosphorylated at S214	human, mouse
Tau phos Ser235 (MC6)	MC6 (Gregory Jicha, Departments of Pathology and Neurpscience, Albert Einstein College of Medicine) References: Vingtdeux, 2010 Planel, 2008	immunogen = affinity purified PHF (epitope around phosphor. Ser235)	monoclonal mouse	ELISA, IB	recognizes tau phosphor. at Ser235; not reactive to non-phosphor. tau. paper Jincha, et al. 1997	human
Tau phos Ser396/Ser404 (PHF-1) IgG₁	Tau-002 (Peter Davies, Department of Path., Albert Einstein College of Med.) References: Bhaskar K, 2010 Zempel H, 2010 van Eersel, 2010 Min SW, 2010 Tackenberg, 2009 Zhang, 2009 Adams, 2009 Polydoro, 2009 Sontag, 2008 Roberson, 2007 Neumann, 2006	epitope around Ser396 and Ser404 phosphorylated sties	monoclonal mouse	ELISA, IH, IP, WB
Tau phos Ser409 (PG5) IgG3	Peter Davies, Department of Pathology, Albert Einstein College of Medicine Paper, Jicha GA, et al., 1999 Reference: Vingtdeux, 2010	immunogen = the synthetic phosphopeptides KSPRHLS(P)NV S(P)STGS(P)ID and KSPRHLS(P)NV SS(P)TGSID	monoclonal mouse	ELISA, IH, WB	recognizes the PKA-dependent phosphorylation of ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts with only PHF and the tau peptide containing phospho ser409	human, mouse
Tau phos Thr231 (2E12)	Peter Davies, Department of Pathology, Albert Einstein College of Medicine Reference: Vingtdeux, 2010	epitope around phospho Threonine 231	monoclonal mouse		highly specific for tau phospho. at Thr231	human, mouse
Tau, 4-repeat section (poly)	K9JA (E-M. Mandelkow, Max-Planck-Unit for Struct. Mol. Biol). This antibody is avaliable from DAKO as A0024 Reference: Wang, 2007	epitope comprises the 4 repeats of Tau, starting at Q244 (preceded by M) and extends to the C-terminus (L441)	polyclonal rabbit	IH, IP, WB	recognizes the 4-repeat section of tau; binds very tightly	human
Tau, C-terminal (poly)	TauC (Hitomi Ueno, Laboratory of Molecular Biology, Graduate School of Environmental Health Sciences, Azabu University) Reference: Ueno, 2007	immunogen = synthetic peptide, (SPQLATLA DEVSASLAK) corresp. to the Cterminal residues 422–438 of human tau	polyclonal rabbit	WB		human
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau, four-repeat (poly)	T4R (Hitomi Ueno, Laboratory of Molecular Biology, Graduate School of Environmental Health Sciences, Azabu University) Reference: Ueno, 2007	immunogen = synthetic peptide, PGGGSVQIVYK; this sequence was derived from the boundaries of R2-R3 in 4R-tau (the isoform-specific residue, ₃₀₅S, and the PHF6 motif [³⁰⁶VQIVYK³¹¹] were critical sequences)	polyclonal rabbit (liquid, serum)	WB	recognized specific short sequences at the junction of the repeat domains. The PHF6 motif and the amino acid residue immediately N-terminal to it is also critical for binding. T4R may reflect the state of tau solubility associated with formation of the thioflavin-positive β-structure. No cross with T3R.
Tau, N-terminal (poly)	SA4473 (E-M. Mandelkow, Max-Planck-Unit for Struct. Mol. Biol) Reference: Wang, 2007	immunogen = peptide sequence derived from the first near-N-terminal insert of Tau, CDGSEEPG SETSDAKST, aa 54-69, preceded by a cysteine for coupling	polyclonal rabbit	IF, IH, IP	recognizes Tau isoforms that contain the first or both of the near-N-terminal inserts; recognizes full length htau40ΔK280, but not S258–I360	human
Tau, three-repeat (poly)	T3R (Hitomi Ueno, Laboratory of Molecular Biology, Graduate School of Environmental Health Sciences, Azabu University) Reference: Ueno, 2007	immunogen = synthetic peptide, PGGGKVQIVYK; this sequence was derived from the boundaries of R1-R3 in 3R-tau (the isoform-specific residue, ₃₀₅K, and the PHF6 motif [³⁰⁶VQIVYK³¹¹] were critical sequences)	polyclonal rabbit (liquid, serum, affinity purified)	WB	recognized specific short sequences at the junction of the repeat domains. The PHF6 motif in R3 and the amino acid residue immediately N-terminal to it is also critical for binding. T3R may reflect the state of tau solubility associated with formation of the thioflavin-positive β-structure. No cross with T4R.
Tau, total (poly)	92e (Inge Grundke-Iqbal, Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities) research Paper Reference: Alonso, 2010		polyclonal rabbit (antiserum)	WB	recognizes both phosphorylated and non phosphorylated tau	human
Tau, truncated at Asp421 (C3) IgG₁	TauC3 (Vincent L. Cryns, Cell Death Regulation Laboratory, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Chicago, IL) Research paper Reference: Alonso, 2010	immunogen = KLH- C S S T G S I D M V D, corresp. to residues 412-421 at the C-terminus of tau truncated at Asp421	monoclonal mouse (purified IgG, HEPES, saline, glycerol.)	IF, IH, WB	recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu³⁹¹ or Ala⁴²⁹	human
Tau₄₁₀ (poly)	134d (Inge Grundke-Iqbal, Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities) research Paper Reference: Alonso, 2010	immunogen = recombinant human Tau₄₁₀	polyclonal rabbit (antiserum)	IH, WB	recognizes tau in a phosphorylation independent manner	human
From the Manufacturers
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
14-3-3 Tau (3B9) IgG₁	Abcam Cat# ab10439	immunogen = recomb. full length protein	monoclonal mouse (liquid, protein-G, glycerol, PBS, azide)	IP, WB	recognises theta/tau isoform; no cross with the 14-3-3 zeta isoform	human, rat, mouse, cow (others not tested)
14-3-3 Tau (3i2) IgG₁	Abcam Cat# ab14126	immunogen = synthetic phospho(Ser) 14-3-3 binding motif peptides (KLH coupled)	monoclonal mouse (liquid, HEPES, NaCl, glycerol, protein A purified)	ELISA, IP, WB	recognises the phospho 14-3-3 binding motif
14-3-3 Tau (poly) IgG	Abcam Cat# ab14127	immunogen = synthetic phospho (Ser) 14-3-3-binding-motif peptides	polyclonal rabbit (liquid, HEPES, NaCl, BSA, glycerol, protein A purified)	ELISA, IH(P), IP, WB	phospho 14-3-3 binding motif; weakly crossreacts with seq. containing phospho-Thr in this motif and with seq. containing phospho-Ser surrounded by Phe at the +1 position and Arg/Lys at the -3 position. No cross-reactivity with corresp. non-phospho-rylated seq. or with other phospho-Thr/Ser/Tyr-containing motifs.
14-3-3 Tau/Theta (3B9) IgG	AbD Serotec Cat# 0100-0079	immunogen = native	monoclonal mouse (liquid, PBS, azide, glycerol)	ELISA, WB	14-3-3 tau/theta (31-32 kDa)	human, rat, mouse, bovine
14-3-3 theta (5J20) IgG₁	US Biological Cat# 0014-21	immunogen = recombinant 14-3-3 theta/ tau (a single protein which is known by the alternative names 14-3-3 theta and 14-3-3 tau)	monoclonal mouse (liquid, PBS, azide, glycerol, purified)	ELISA, IP, WB	specifically recognizes 14-3-3 theta/tau; no cross reaction with 14-3-3 sigma. 14-3-3 theta/tau is expressed by brain tissue and cells of the male germ line	human
MAP Tau (4F1) IgG₁	A B R - Thermo Scientific Cat# MA1-83333	immunogen = bovine microtuble associated proteins (MAPS)	monoclonal mouse (liquid, PBS, azide)	IH(F, P), WB	detects MAP tau	human, primate (various), bovine, chicken
MAP tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-18272	immunogen = recomb., human MAP tau (residues 240-450)	polyclonal rabbit (protein-G purified, lyophilized)	IH(F, P), WB	detects MAP tau	rat, mouse
MAP Tau (4F1) IgG₁	Biogenesis AdB Serotec Cat# 6242-0206	immunogen = bovine microtubule associated proteins	monoclonal mouse (liquid, PBS, ascites, azide, diluted)	IH(F, P), WB	phosphorylated and non phosphorylated forms, not other MAPs or tubulin.	monkey, human, bovine, chicken
MAP2 + Tau (poly)	AbD Serotec Cat# 6242-0039	immunogen = native, from brain	polyclonal rabbit (liquid, serum, PBS, azide, purified)	IH(F), WB	tau and MAP2	rat, bovine
MAP2, Tau (poly) IgG	Biogenesis AdB Serotec Cat# 6242-0039	immunogen = bovine native, from brain	polyclonal rabbit (purified Ig, PBS, azide)	IH(F), WB	MAP2 protein and to a lesser extent Tau	rat, bovine
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
MAP-Tau (N.A.) IgG₁	SMI™ COVANCE Cat# SMI51	(aa 95 to 108 sequence of tau in a conformation partially dependent on serine in position 101)	monoclonal mouse (high titer, ascites)	IH(F, V), WB; not IH(P)	strongly with PHF Tau in Alzheimer disease; weakly with normal tau	rat, bovine
Tau (HYB338-01) IgG_2a,κ	Abcam Cat# ab27162	immunogen = synthetic peptide: N-terminal Tau peptide seq. with an additional cysteine at the C- terminal and coupled to S3 protein	monoclonal mouse (liquid, PBS, no preservative, protein A purified)	ELISA	Tau_5-12, N-terminal Tau peptide and Tau protein	human
Tau (T1) IgG₁	Abcam Cat# ab12354 discontinued	immunogen = full length protein (human)	monoclonal mouse (liquid, protein-A, sucrose, PBS, azide)	WB	recognises multiple Tau isoforms; 78.7 kDa band by WB	human, rat, mouse, cow (others not tested)
Tau (TAU 46) IgG₁	Abcam Cat# ab24747	immunogen = synthetic peptide: K N R P C L S P K L P T P G S S D P L I Q P S S P A V C P E P P S S P K H V, corresp. to C- terminal aa 404-441 of human Tau	monoclonal mouse (liquid, ascites, no preservative)	IP, WB	recognizes all six isoforms of Tau	human, rat, rabbit, xenopus (other species not tested)
Tau (TAU 46) IgG₁	Abcam Cat# ab22261	immunogen = synthetic peptide: K N R P C L S P K L P T P G S S D P L I Q P S S P A V C P E P P S S P K H V, corresp.to aa 404-441 of human Tau	monoclonal mouse (liquid, PBS, ascites, protein a purified)	ELISA, WB	Tau	human (expect cow, orangutan, common gibbon, chimpanzee, lowland gorilla due to seq. homology)
Tau (TAU2) IgG₁	Abcam Cat# ab12356	immunogen = recomb. full length protein	monoclonal mouse (liquid, protein-A, BSA, PBS, azide)	IH	reacts with 52-68 kDa tau in the phospho. and non-phospho. forms; intensely stains the human neurofibrillary tangles, neuropil threads and neuritic plaques, also astrocytes and ribosomes	monkey, human, cow, chicken (others not tested)
Tau (TAU2) IgG₁	Abcam Cat# ab12357	immunogen = recomb. full length protein	monoclonal mouse (liquid, protein-A, BSA, PBS, azide, Biotin conj.)	IH	reacts with 52-68 kDa tau in the phospho. and non-phospho. forms; intensely stains the human neurofibrillary tangles, neuropil threads and neuritic plaques, also astrocytes and ribosomes	monkey, human, cow, chicken (others not tested)
Tau (TAU2) IgG₁	Abcam Cat# ab12359	immunogen = recomb. full length protein	monoclonal mouse (liquid, protein-A, BSA, PBS, azide, Fluorescein conj.)	IH	reacts with 52-68 kDa tau in the phospho. and non-phospho. forms; intensely stains the human neurofibrillary tangles, neuropil threads and neuritic plaques, also astrocytes and ribosomes	monkey, human, cow, chicken (others not tested)
Tau (TAU-5) IgG₁,κ	Abcam Cat# ab8739 Discontinued	immunogen = purified bovine microtubule associated proteins	monoclonal mouse (liquid, supernate, tris, fetal bovine serum, carriers, azide)	IH(F, P)	reacts with Tau proteins and with Tau from Alzheimer paired helical filaments; no cross with MAP 1, MAP 2, MAP 5 or tubulin; binds phospho. as well as non-phospho. forms of tau	monkey, human, cow, chicken (others not tested, not mouse, rat;)
Tau (TAU-5) IgG₁	Abcam Cat# ab3931 Reference: Min SW, 2010	immunogen = purified bovine microtubule associated proteins	monoclonal mouse (liquid, IgG fraction, PBS, azide. For BSA and azide free, see ab80579)	IH(F, P), WB	specific to 45-68 kDa proteins identified as tau proteins; no cross with tubulin or other MAPs; phospho. as well as non-phospho. forms of tau	human (others not tested)
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (poly) IgG	Abcam Cat# ab8763		polyclonal rabbit (liquid, whole antiserum, tris, fetal bovine serum, carriers, azide)	IF, IH(F, P)	reacts with Tau proteins and with Tau from Alzheimer paired helical filaments; no cross with MAP 1, MAP 2, MAP 5 or tubulin; binds phospho. as well as non-phospho. forms of tau	human (others not tested)
Tau (poly) IgG	Abcam Cat# ab11107	immunogen = synthetic peptide: M A E P R Q E F E V M E D H A G, corr. to aa 1-16 of human Tau	polyclonal goat (liquid, whole antiserum, azide)	IH(P), WB	reacts with Tau, a 50-67 kD heterogeneous group of proteins; 52.9 kDa in WB	human (others not tested, expect macaque;)
Tau (poly) IgG	Abcam Cat# ab24230	immunogen = synthetic peptide, A K T D H G A E I V pY K S P, corresp. to aa 384-397 of human Tau, conjugated to KLH	polyclonal rabbit (liquid, PBS, azide)	WB	detects both non-phosphorylated and tau phosphorylated at tyrosine 394	human (expect mouse, rat and wide range of species due to seq. homology)
Tau (poly) IgG	Abcam Cat# ab22690	immunogen = synthetic peptide, (C)-G D R K D Q G G (p)T M H Q Q E, corresp. to aa 21-36 of human Tau, conjugated to KLH	polyclonal rabbit (liquid, PBS, azide)	IH(F, P), WB	detects both non-phosphorylated and p56 lck phosphorylated tau	human (other species not tested)
Tau (poly) IgG	Abcam Cat# ab31356	immunogen = synthetic non-phosphoeptide (human) - derived from around the phosphorylation site of Ser235	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	detects endogenous levels of Tau protein around Serine 235	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab31357	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site Threonine 231.	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	Tau	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab31359	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 404	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	Tau	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab39524	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of Threonine 181.	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab39526	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of threonine 205	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab39528	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 214	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	tau	human, rat, mouse (other species not tested)
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (poly) IgG	Abcam Cat# ab39532	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 262	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	binds the Tau protein in the region around Serine 262 (~44-48kDa)	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab39651	immunogen = synthetic peptide non-phospho-rylated derived from human Tau around the phosphorylation site of Serine 262	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab39679	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 396	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab22688	immunogen = synthetic peptide, H E D H A G T (p)Y G L G D R K D Q G (C), corresp. to aa 12/27 of human Tau, conjugated to KLH	polyclonal rabbit (liquid, PBS, azide)	IH(P), WB	recognises tau isoform 6, both non phosphorylated and p56lck phosphorylated tau	human (expect chimpanzee, gorilla, Macaque monkey due to seq. homology; other species not tested)
Tau (poly) IgG	Abcam Cat# ab19326	immunogen = synthetic peptide: M A E P R Q E F E V M E D H A G, corresp. to N- terminal aa 1-16 of human Tau	polyclonal goat (liquid, whole sera, azide)	ELISA, WB; not IH	tau	human (expect baboon, chimpanzee, gorilla, Macaque monkey due to seq. homology)
Tau (poly) IgG	Abcam Cat# ab11107	immunogen = synthetic peptide: M A E P R Q E F E V M E D H A G, corresp. to aa 1-16 of human Tau	polyclonal goat (liquid, serum, azide)	IH(P), WB	recognises tau, a 50-67 kD heterogeneous group of proteins	human (expect macque monkey due to seq. homology; other species not tested)
Tau (poly) IgG	Abcam Cat# ab45024	immunogen = recombinant protein encoding C-terminal part of human Tau; epitope = C-terminal	polyclonal rabbit (liquid, PBS, BSA, azide, protein A purified)	IH(P)	tau	human (others not tested)
Tau (poly) IgG	Abcam Cat# ab39524	immunogen = synthetic non-phosphopeptide derived from human Tau around the phosphorylation site of threonine 181	polyclonal rabbit (liquid, PBS, glycerol, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab47568	immunogen = synthetic non-phosphopeptide derived from Human Tau around the phosphorylation site of serine 356 (IGSpLD).	polyclonal rabbit (liquid, PBS, glycerol, saline, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse (other species not tested)
Tau (poly) IgG	Abcam Cat# ab47579	immunogen = synthetic peptide: SRTPS, corresponding to amino acids 210-214 of human Tau, around the phosphorylation site of Threonine 212	polyclonal rabbit (liquid, PBS, glycerol, saline, azide, affinity purified)	ELISA, WB	detects endogenous levels of total Tau protein	human, rat, mouse
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (SPM452) IgG	A B R - Thermo Scientific Cat# MA1-38710	immunogen = purified bovine microtubule associated proteins	monoclonal mouse (affinity purified IgG, PBS, BSA,azide)	IF, IP, WB	detects tau	human, rat, mouse, ovine, bovine
Tau (T1) IgG₁	A B R - Thermo Scientific Cat# MA1-25495	immunogen = full length human protein	monoclonal mouse (liquid, protein-A purified, PBS, sucrose, azide)	WB	detects Tau	human, rat, mouse, bovine
Tau (Tau) IgG₁	A B R - Thermo Scientific Cat# MA1-22818	immunogen = purified bovine microtuble associated proteins (MAPS)	monoclonal mouse (liquid, TrisS, saline, FBS, azide)	IH(F, P)	detects tau	human, primate (various), bovine, chicken
Tau (TAU-5) IgG₁	A B R - Thermo Scientific Cat# MA1-26600	immunogen = purified bovine microtuble associated proteins	monoclonal mouse (liquid, IgG fraction, PBS, azide)	IH(F, P), WB	detects tau from human samples	human
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-38714	immunogen = synthetic peptide corresp. to residues around Serine 404 of human Tau	polyclonal rabbit (affinity purified IgG, PBS, BSA,azide)	WB	detects tau	human
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-38711	immunogen = synthetic peptide corresp. to residues around Serine 202 of human Tau	polyclonal rabbit (affinity purified IgG, PBS, BSA,azide)	WB	detects tau	human
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-38713	immunogen = synthetic peptide corresp. to residues around Serine 396 of human Tau	polyclonal rabbit (affinity purified IgG, PBS, BSA,azide)	WB	detects tau	human
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-38712	immunogen = synthetic peptide corresp. to residues around Threonine 205 of human Tau	polyclonal rabbit (affinity purified IgG, PBS, BSA,azide)	IP, WB	detects tau	human
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-14428	immunogen = synthetic peptide derived from human Tau around the phospho. site of serine 422 (V-D-S-P-P-Q)	polyclonal rabbit (liquid, PBS, saline ,azide, glycerol)	WB	detects tau	human, rat, mouse
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-14427	immunogen = synthetic peptide derived from human Tau around the phospho. site of serine 404 (D-T-S-P-P-R)	polyclonal rabbit (liquid, PBS, salineA ,azide, glycerol)	WB	detects tau	human, rat, mouse
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-14425	immunogen = synthetic peptide derived from human Tau around the phospho. site of serine 396 (Y-K-S-P-P-V)	polyclonal rabbit (liquid, PBS, saline ,azide, glycerol)	WB	detects tau	human, rat, mouse
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-14423	immunogen = synthetic peptide derived from human Tau around the phospho. site of serine 262 (I-G-S-P-T-E)	polyclonal rabbit (liquid, PBS, saline ,azide, glycerol)	WB	detects tau	human, rat, mouse
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-14421	immunogen = synthetic peptide derived from human Tau around the phospho. site of serine 235 (P-K-S-P-P-S)	polyclonal rabbit (liquid, PBS, saline ,azide, glycerol)	WB	detects tau	human, rat, mouse
Tau (poly) IgG	A B R - Thermo Scientific Cat# PA1-14417	immunogen = synthetic peptide derived from human Tau around the phospho. site of threonine 212 (S-R-T-P-P-S)	polyclonal rabbit (liquid, PBS, saline ,azide, glycerol)	WB	detects tau	human, rat, mouse




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