|
Antibodies to Amyloid Beta and related Proteins
|
| From the Laboratories
|
Antigen
(Clone)
IgG |
Name
(Source)
used in |
Immunogen
(Epitope) |
Host
(Formulation) |
Methods
glossary |
Specificity |
Reactivity top |
Aβ38
(kit)
|
anti-Aβ38
(Pankaj Mehta,
Department of Immunology, New York State Institute for Basic Research, Staten Island, New York)
Paper: Potempska A, Mack K, Mehta PD, et al. Quantitation of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid: Int J Clin Invest 1999;16:14-21 |
immunogen (detection antibody) = peptide hCys-aminohexoanoyl-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-GlyOH |
(Sandwich ELISA
monoclonal antibody 6E10 (Signet Labs) is used as capture antibody
rabbit antiserum to Aβ38 is used as the detection antibody) |
ELISA |
detects amyloid-beta 38; no reaction to Aβ40 or Aβ42 |
human |
| From the Manufacturers
|
Antigen
(Clone)
IgG |
Distributor
(Producer) |
Immunogen
(Epitope) |
Host
(Formulation) |
Methods
glossary |
Specificity |
Reactivity top |
β-Amyloid [1-17]
(6E10)
IgG1
|
Sigma Aldrich
Cat# A1474
References:
Serneels, 2009
Jimenez, 2008
Vasilevko, 2007 |
immunogen = synthetic peptide corr. to aa 1-17 of β-amyloid, with Glu substituted at position 11, conjugated to KLH. Epitope at aa 1-12 |
monoclonal mouse
(ascites, protein-G, PBS, thimerosal) |
ELISA, IH, IP, WB |
monoclonal recognizes aa 1-17 of human amyloid β peptide; also recognizes the precursor forms and abnormally processed isoforms |
human, mouse
(mouse at high concentrations) |
β-Amyloid 1-16 or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
(marketing for Senetek)
Cat# SIG-39347
References:
Chung, E, 2010
Clinton, 2010
Zhao XL, 2010
Hock, 2002
Zhang, 2009
Liu, 2009
Varvel, 2009
Rose, 2009
(all, unspecified formulation) |
the epitope lies within amino acids 4-9 of beta amyloid (FRHDSG) |
monoclonal mouse
(liquid, protein-A purified, PBS, no preservative or carrier proteins, AlexaFluor® labeled) |
ELISA, IH |
reactive to aa 1-17 Aβ reacts to the abnormally processed isoforms, as well as precursor forms |
human |
β-Amyloid 1-16 or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
Cat# SIG-39340
References:
Tian Y, 2010)
Roberson, 2007
Matsuoka, 2003
(unspecified formulation for:
Lewis TL, 2010
Lefterov, 2010
Lee, S, 2010
He, 2009
Czirr, 2008
Sato, 2007 ) |
the epitope lies within amino acids 3-8 of beta amyloid (EFRHDS) |
monoclonal mouse
(biotinylated IgG, PBS, no preservatives or carrier proteins) |
ELISA, IH, IP, WB |
reactive to aa 1-16 Amyloid β; reacts to the abnormally processed isoforms, as well as precursor forms |
human |
β-Amyloid 1-16 or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
Cat# SIG-39345
References:
Soscia, 2010
Puzzo, 2008 |
epitope = lies within aa 3-8 of the β-amyloid peptide (EFRHDS) |
monoclonal mouse
(liquid, PBS, no preservatives or carrier proteins, purified, HRP conj.) |
ELISA, IH(P), WB |
reactive to aa 1-16 of β-Amyloid (precursor forms as well as abnormally processed isoforms |
human |
β-Amyloid 1-16 or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
Cat# SIG-39330
References:
Oddo, 2005
Caccamo, 2006
Deng, 2006
Rockenstein, 2007 |
epitope = lies within aa 3-8 of β-amyloid peptide (EFRHDS) |
monoclonal mouse
(liquid, purified F(ab')2 frag of clone 6E10 monoclonal ab, PBS, no preservatives or carrier proteins) |
ELISA, IH(P), WB |
reactive to aa 1-16 of β-amyloid peptide (precursor forms and abnormally processed isoforms) |
human |
β-Amyloid 1-16 or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
Cat# SIG-39320
References:
Tian Y, 2010
Townsend, 2007
Parkin, 2007
References (unspecified formulation):
Zhang Y, 2010
Wang, J, 2010
Heneka, 2010
Kim, 2009
Wilcock, 2009
Moreno, 2009
Ho, 2009
Jacobsen, 2008
Wang, 2007 |
epitope = lies within aa 3-8 of the β-amyloid peptide (EFRHDS) |
monoclonal mouse
(liquid, PBS, no preservatives or carrier proteins, protein-G purified) |
ELISA, IH(P), WB |
reactive to aa 1-16 of β-Amyloid (precursor forms as well as abnormally processed isoforms |
human |
β-Amyloid 1-16 or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
Cat# SIG-39321 |
epitope lies within amino acids 3-8 of the beta Amyloid peptide (E F R H D S) |
monoclonal mouse
(liquid, PBS; no preservatives or carrier proteins) |
ELISA, IH, IP, WB |
reactive to amino acid residue 1-16 of beta amyloid.; reacts to the abnormally processed isoforms, as well as precursor forms |
human |
β-Amyloid 1-16, or APP
(6E10)
IgG1
|
Covance Research Products, Inc.
Cat# SIG-39300
Referencess:
Osawa, 2008
Kalhoff, 2007
Tampellini, 2007
Ostrowski, 2007
(all, unknown formulation)
Mi, 2007 |
the epitope lies within amino acids 3-8 of beta amyloid (EFRHDS) |
monoclonal mouse
(crude ascites) |
ELISA, IH, IP, WB; affinity purification |
reactive to aa 1-16 of Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms |
human |
Amyloid-β 38
(kit)
|
Meso Scale Discovery
Cat# K111FSE-1 (1 plate)
Cat# K111FSE-2 (5 plate)
Cat# K111FSE-3 (20 plate)
Reference:
Fagan, 2009 |
epitope lies within amino acids 4-9 of the beta Amyloid peptide (FRHDSG) |
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 38 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 38 peptide in human cerebrospinal
fluid (CSF) |
human |
Amyloid-β 38
(kit)
|
Meso Scale Discovery
Cat# K110FSA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 38 Antibody 4G8, protocol) |
ELISA |
recognizes human beta Amyloid 38 peptide |
human, rat, mouse |
Antigen
(Clone)
IgG |
Distributor
(Producer) |
Immunogen
(Epitope) |
Host
(Formulation) |
Methods
glossary |
Specificity |
Reactivity top |
Amyloid-β 38
(kit)
|
Meso Scale Discovery
Cat# K111FWA-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 38 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 38 peptide |
human, rat, mouse |
Amyloid-β 38
(kit)
|
Meso Scale Discovery
Cat# K111FSA-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 38 Antibody 4G8, Capture antibody 6E10; protocol) |
ELISA |
recognizes human beta Amyloid 38 peptide |
human, rat, mouse |
Amyloid-β 38
(kit)
|
Meso Scale Discovery
Cat# K111FWE-1(1 plate)
Cat# K111FWE-2 (5 plate)
Cat# K111FWE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 38 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 38 peptide |
human |
Amyloid-β 38/40/42
(kit)
|
Meso Scale Discovery
Cat# K11148A-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid38, 40, 42 peptide |
human |
Amyloid-β 38/40/42
(kit)
|
Meso Scale Discovery
Cat# K15148A-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid38, 40, 42 peptide |
human |
Amyloid-β 38/40/42
(kit)
|
Meso Scale Discovery
Cat# K11141E-1 (1 plate)
Cat# K11141E-2 (5 plate)
Cat# K11141E-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ Antibody 4G8, protocol) |
ELISA |
recognizes human beta Amyloid 38, 40, 42 peptide |
human, rat, mouse |
Amyloid-β 38/40/42
(kit)
|
Meso Scale Discovery
Cat# K11148E-1 (1 plate)
Cat# K11148E-2 (5 plate)
Cat# K11148E-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 38, 40, 42 peptide |
human |
Amyloid-β 38/40/42
(kit)
|
Meso Scale Discovery
Cat# K15141E-1 (1 plate)
Cat# K15141E-2 (5 plate)
Cat# K15141E-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ Antibody 4G8, protocol) |
ELISA |
recognizes human beta Amyloid 38, 40, 42 peptide |
human, rat, mouse |
Amyloid-β 38/40/42
(kit)
|
Meso Scale Discovery
Cat# K15148E-1 (1 plate)
Cat# K15148E-2 (5 plate)
Cat# K15148E-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 38, 40, 42 peptide |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K111BVA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human |
Antigen
(Clone)
IgG |
Distributor
(Producer) |
Immunogen
(Epitope) |
Host
(Formulation) |
Methods
glossary |
Specificity |
Reactivity top |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K151BVA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K151FTE-1 (1 plate)
Cat# K151FTE-2 (5 plate)
Cat# K151FTE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K111FTA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide in cerebral spinal fluid samples |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K151FTA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide in cerebral spinal fluid samples |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K110FTE-1 (1 plate)
Cat# K110FTE-2 (5 plate)
Cat# K110FTE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 4G8, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human, rat, mouse |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K111BVE-1 (1 plate)
Cat# K111BVE-2 (5 plate)
Cat# K111BVE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K111FTE-1 (1 plate)
Cat# K111FTE-2 (5 plate)
Cat# K111FTE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K150FTE-1 (1 plate)
Cat# K150FTE-2 (5 plate)
Cat# K150FTE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 4G8, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human, rat, mouse |
Amyloid-β 40
(kit)
|
Meso Scale Discovery
Cat# K151BVE-1 (1 plate)
Cat# K151BVE-2 (5 plate)
Cat# K151BVE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 40 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 40 peptide |
human |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K111BWA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes beta Amyloid 42 peptide |
human |
Antigen
(Clone)
IgG |
Distributor
(Producer) |
Immunogen
(Epitope) |
Host
(Formulation) |
Methods
glossary |
Specificity |
Reactivity top |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K111BWE-1 (1 plate)
Cat# K111BWE-2 (5 plate)
Cat# K111BWE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes beta Amyloid 42 peptide |
human, rat, mouse |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K111FUE-1 (1 plate)
Cat# K111FUE-2 (5 plate)
Cat# K111FUE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes beta Amyloid 42 peptide |
human |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K151BWA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes beta Amyloid 42 peptide |
human |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K151BWE-1 (1 plate)
Cat# K151BWE-2 (5 plate)
Cat# K151BWE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 42 peptide |
human |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K151FUE-1 (1 plate)
Cat# K151FUE-2 (5 plate)
Cat# K151FUE-3 (20 plate) |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes human beta Amyloid 42 peptide |
human |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K151FUA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes beta Amyloid 42 peptide in cerebral spinal fluid samples |
human |
Amyloid-β 42
(kit)
|
Meso Scale Discovery
Cat# K111FUA-3 |
|
mouse
(96 well ELISA, SULFO-TAG™ Anti Aβ 42 Antibody 6E10, protocol) |
ELISA |
recognizes beta Amyloid 42 peptide in cerebral spinal fluid samples |
human |
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