Antibody Directory


	Current Papers
	ARF Recommends
	Milestone Papers
	Search All Papers
	Search Comments


	Research News
	Drug News
	Conference News


	AD Hypotheses
		AlzSWAN
		Current Hypotheses
		Hypothesis Factory
	Forums
		Live Discussions
		Virtual Conferences
		Interviews
	Enabling Technologies
		Workshops
		Research Tools
	Compendia
		AlzGene
		AlzRisk
		Antibodies
		Biomarkers
		Mutations
		Protocols
		Research Models
		Video Gallery
	Resources
		Bulletin Boards
		Conference Calendar
		Grants
		Jobs


	Overview
	Diagnosis/Genetics
	Research
	News
	Profiles
	Clinics


	Companies
	Tutorial
	Drugs in Clinical Trials


	About Alzheimer's
		FAQs
	Diagnosis
		Clinical Guidelines
		Tests
		Brain Banks
	Treatment
		Drugs and Therapies
	Caregiving
		Patient Care
		Support Directory
		AD Experiences


	Member Directory
	Researcher Profiles
	Institutes and Labs


	Mission
	ARF Team
	ARF Awards
	Advisory Board
	Sponsors
	Partnerships
	Fan Mail
	Support Us

Home: Research: Compendia: Antibodies

Antibody Directory


	Initial Search


Antigen Class:

(plus) Keywords:		any keywords all keywords


Search Results:		Antigen Class=Amyloid-beta related

Narrow Results

Host:	Method:	Species Reactivity:	Distributor:

	and	and

exclude selected host


	1 to 100 of 617 results


	Important Notice: We are striving to include as many companies or products as possible, but we do not make a claim to being comprehensive. We may inadvertently omit specific companies or products due to a lack of information.

Antibodies to Amyloid Beta and related Proteins
From the Laboratories
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
β-Amyloid (mono)	anti β-Amyloid (Edward Koo, Univ. of California, San Diego, CA) Reference: Lee, 2002		monoclonal	WB	beta amyloid
β-Amyloid (poly)	anti β-Amyloid (Edward Koo, Univ. of California, San Diego, CA) Reference: Lee, 2002		polyclonal	WB	beta amyloid
β-Amyloid oligomers (mono) IgG₁	NAB61 (Edward B. Lee et al., U. Pennsylvania Center for Neurodegenerative Disease Research) Reference: Lee, 2006	Treating synthetic Aβ1-40 with peroxynitrite, a reactive species generated by the reaction between superoxide and nitric oxide, resulted in the formation of SDS-stable Aβ oligomers. One hybridoma was generated from a mouse immunized with nitrated Aβ	monoclonal mouse	IB, IC, IF, IP	preferentially recognizes a conformational epitope present in dimeric, small oligomeric, and higher order Aβ structures but not full-length Aβ precursor protein or C-terminal amyloid-beta precursor protein fragments. NAB61 also recognized a subset of brain Aβ deposits, preferentially mature senile plaques, and amyloid angiopathy. Aged transgenic mice treated with NAB61 displayed significant improvements in spatial learning and memory relative to control mice	human, mouse
β-Amyloid oligomers (NU-1)	anti β-Amyloid oligomers (paper, Mary Lambert et al., Northwestern University, Evanston, IL, USA) References: Varvel, 2009 Jimenez, 2008	immunogern = Aβ oligomers (amyloid β-derived diffusible ligands, ADDLs), mixed with Freund's adjuvant (we suggest that the NU-1 and NU-4 epitope is three-dimensional, in which aggregation of Aβ1–28 to form a dimer is necessary to align correct amino acids in the binding pocket, perhaps several from each single peptide)	monoclonal mouse	DB, WB	strong preferential binding for Aα oligomers over monomers; neutralizes binding of endogenous and synthetic ADDLs to cultured cells; binds strongly to Alzheimer's disease brain samples but not to control brain samples; reactivity prominent in the hippocampus, entorhinal cortex, and middle frontal gyrus of Alzheimer's disease brain	human, mouse
β-Amyloid oligomers (NU-2)	anti β-Amyloid oligomers, ADDL (paper, Zhao W-Q. et al., Northwestern University, Evanston, IL, USA) Reference: Varvel, 2008	immunogern = Aβ oligomers (amyloid β-derived diffusible ligands, ADDLs), mixed with Freund's adjuvant	monoclonal mouse	DB, WB	shows weak binding to Alzheimer's disease brain extract but still discriminated between Alzheimer's disease and control brain; shows little to no staining of monomers	human, mouse
β-Amyloid oligomers (NU-4)	anti β-Amyloid oligomers (paper, Mary Lambert et al., Northwestern University, Evanston, IL, USA) References: De Felice, 2009 Jimenez, 2008	immunogern = Aβ oligomers (amyloid β-derived diffusible ligands, ADDLs), mixed with Freund's adjuvant (we suggest that the NU-1 and NU-4 epitope is three-dimensional, in which aggregation of Aβ1–28 to form a dimer is necessary to align correct amino acids in the binding pocket, perhaps several from each single peptide)	monoclonal mouse	DB, WB	The species recognized by NU-4 in western blots included lower order and prominent higher order oligomers (12–24mers). Aβ1–40 monomer was not recognized in immunoblots by NU-4. NU-4 binds strongly to Alzheimer's disease brain samples but not to control brain samples	human, mouse
β-Amyloid protofibrils, β-Amyloid N-terminus (mono) IgG₂	PFA1 (lab of Chris Dealwis, Univ. of Tennessee, Knoxville, TN) Reference: Gardberg, 2007	immunogen = CLC-stabilized protofibril form of Aβ(1–40); epitope within Aβ(1–8); DAEFRHDS, at the N terminus	monoclonal mouse (liquid, protein-A affinity purified)	ELISA	The Fab fragments exhibit binding to Aβ monomers in the 20–40 nM range, and this binding is significantly impaired or eliminated in Aβ(1–40) mutants in which a single residue in the 3–7 segment is replaced with alanine. The full IgG molecules bind significantly better than Fab fragments to Aβ fibrils and protofibrils (0.1–0.2 nM); PFA1 binds more tightly to fibrils than does PFA2. diminished affinity for pyroglutamate-Glu forms of Aβ	human
β-Amyloid protofibrils, β-Amyloid N-terminus (mono) IgG₂	PFA2 (lab of Chris Dealwis, Univ. of Tennessee, Knoxville, TN) Reference: Gardberg, 2007	immunogen = CLC-stabilized protofibril form of Aβ(1–40); epitope within Aβ(1–8); DAEFRHDS, at the N terminus	monoclonal mouse (liquid, protein-A affinity purified)	ELISA	The Fab fragments exhibit binding to Aβ monomers in the 20–40 nM range, and this binding is significantly impaired or eliminated in Aβ(1–40) mutants in which a single residue in the 3–7 segment is replaced with alanine. The full IgG molecules bind significantly better than Fab fragments to Aβ fibrils and protofibrils (0.1–0.2 nM); PFA1 binds more tightly to fibrils than does PFA2. diminished affinity for pyroglutamate-Glu forms of Aβ	human
β-Amyloid, C-terminal (mono)	Abeta1.1 (Axelsen TV, et al,, Faculty of Health Science, Aarhus University, Arhus N, Denmark. The paper is an ARF Paper of the Week	immunogen = a unique antigen construct made by the Ligand Presenting Assembly technology, resulting in dimeric presentation of the free C-terminal end. (the paratope of the antibody must enclose the C-terminal end of Abeta(42) including the carboxy-group of amino acid 42, and not just recognize a linear epitope in the C-terminal part of Abeta.)	monoclonal mouse	IH	targets the C-terminal end of Abeta(42) with high specificity
Aβ (mono)	amyloid beta 12B4 (Frederique Bard, Elan Pharma- ceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein	monoclonal (supernat, RIA screened, HPLC purified)	IH, WB	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 1004:2023-8, 2003)
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Aβ (mono)	amyloid beta 2C1 (Frederique Bard, Elan Pharma- ceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein	monoclonal mouse (supernat, RIA screened, HPLC purified)	IH, WB	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 1004:2023-8, 2003)
Aβ (mono)	amyloid beta 12A11 (Frederique Bard, Elan Pharma- ceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein	monoclonal (supernat, RIA screened, HPLC purified)	IH, WB	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 1004:2023-8, 2003)
Aβ (mono)	Aβ-42 EL26 (Frederique Bard, Elan Pharma- ceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = amyloid beta (7-1)-42; epitope = aa 11-26	monoclonal	IH	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 100:2023-8, 2003)
Aβ (mono)	anti-amyloid beta (Paul Gottschall, Univ South Florida Col of Med. Dept of Pharmacology & Therapeutics, Tampa, FL) Reference: Jantzen, 2002		monoclonal		amyloid-beta
Aβ (10D5) IgG₁	amyloidβ 10D5 (F Bard, Elan Pharmaceuticals, South San Francisco, CA paper: Bard, et al., PNAS Feb 3, 2003) Reference: Price, 2009 Roberson, 2007	immunogen = synthetic Aβ_1–28 coupled to a carrier protein (epitope at aa. 3-7)	monoclonal mouse (purified)	ELISA, FA	binds amyloid plaques and triggers phagocytosis	human, mouse
Aβ (3D6)	anti-amyloid beta 3D6 Paper: Johnson-Wood, et al., PNAS Feb 18, 1997) References: Siderowf, 2010 Yan, 2009 Britschgi, 2009 Brody, 2008 Schroeter, 2008 Shankar, 2008 Meyer-Luehmann, 2008 Choi, 2006 Roberson, 2007	immunogen = synthetic peptide fragment coupled to a carrier protein; epitope at aa 1-5 within Amyloid-beta 1-42	monoclonal mouse	ELISA, IH, WB; detection antibody	amyloid-beta (recognizes amino acids 1-5); does not recognize secreted APP or APP-FL but detects only Aβ species with amino-terminal aspartic acid Useful in amyloid-beta plaque clearence and reduction	human, mouse
Aβ (BAN50)	BAN-50 (N Suzuki, Takada Chemical Industries) References: Wang S, 2010 Fukumoto, 2010 Suzuki, 1994	raised against Aβ 1-16 (epitope at aa 1-10)	monoclonal mouse	ELISA, WB	amyloid-beta	human, mouse
Aβ (N/A)	amyloid-beta 86/31 (C. Masters) Reference: Pfiefer, 2002		monoclonal	IH
Aβ (poly)	Aβ 1-42 (Frederique Bard, Elan Pharmaceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = full length amyloid beta 1-42; epitope at aa 1-11	polyclonal (Ig, ammmonium sulfate precip.)	IH, WB	amyloid-beta	(reference Bard F, Cannon C, Barbour R, Burke R L, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, et al, Nat. Med. 6: 916-919, 2000)
Aβ (poly)	anti-amyloid beta EL16 (Frederique Bard, Elan Pharmaceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = amyloid-beta aa 1-7	polyclonal (Ig, ammmonium sulfate precip.)	IH, WB	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 100:2023-8, 2003)
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Aβ (poly)	anti-amyloid beta EL17 (Frederique Bard, Elan Pharmaceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = amyloid-beta aa 15-24	polyclonal (Ig, ammmonium sulfate precip.)	IH, WB	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 100:2023-8, 2003)
Aβ (poly)	anti-amyloid beta EL20 (Frederique Bard, Elan Pharmaceuticals, So. San Francisco, CA) Reference: Bard, 2003	immunogen = amyloid beta aa 3-9	polyclonal (Ig, ammmonium sulfate precip.)	IH, WB	amyloid-beta	(reference F. Bard et al, Proc Natl Acad Sci U S A 100:2023-8, 2003)
Aβ (poly)	R1282 (Dennis Selkoe) References: Shankar, 2008 Lesné, 2006, Maier, 2006, 2008, Pfeifer, 2002, Van Uden, 2002, Buttini, 2002	immunogen = synthetic peptide NH₂- CYS-NH-CH2- (CH2)5-CO- GLMVGGVVIA- COOH.	polyclonal rabbit		very high specificity for Ab_1–42 over Ab_1–40
Aβ (poly)	2964 (Jochen Walter, Department of Neurology, University of Bonn, Bonn, Germany) Paper Reference: Heneka, 2010	immunogen = synthetic Aβ40	polyclonal rabbit	IP	detects Aβ	human, mouse
Aβ (poly)	3552 (Harald Steiner, Laboratory for Alzheimer’s and Parkinson’s Disease Research, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany) Paper Reference: Kuhn, 2010	immunogen = Aβ1–40	polyclonal	IP, WB	recognizes amyloid-beta	human
Aβ 1-15 (mono)	JRF/rAβ1-15/2 (Paul Mathews, New York University, School of Medicine, Marc Merken, Johnson & Johnson Pharm. R&D, paper) References: Gandy, 2010	epitope within residues 1-15 of mouse Aβ	monoclonal mouse	ELISA	binds to amyloid-beta	mouse
Aβ 1-16 (mono)	IC16 (Claus U. Pietrzik, Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes-Gutenberg-University Mainz, Mainz, Germany) paper) Reference: Richter L, 2010	immunogen = synthetic human Ab peptide 1–16, cross-linked to keyhole limpet hemocyanin	monoclonal mouse	ELISA, IB	recognizes residues 1-16 of Amyloid β. Hybridoma cells were generated by standard procedures and screened for recognition of HSA cross-linked to Ab 1-16 by ELISA; recognition of synthetic Ab 1–42 on a standardized dot blot procedure was conﬁrmed and the epitope mapped to Ab 1–8 using a peptide array spanning the entire sequence of Ab	human
Aβ 1-23 (poly)	R17 amyloid-beta 1-23 (T Ishii) Reference: Guo J, 2006		polyclonal rabbit
Aβ 1-40 (mono)	JRF/Aβtot/17 (Paul Mathews, New York University, School of Medicine, Marc Merken, Johnson & Johnson Pharm. R&D, paper) References: Gandy, 2010 Trinchese, 2008 Mi, 2007	immunogen = human Aβ_1-40	monoclonal mouse	ELISA, IB	amyloid-beta, binds within residues 1-15	human
Aβ 1-42 (266)	amyloidβ 266 (P Seubert, Elan Pharmaceuticals, South San Francisco, CA, Paper) References: Britschgi, 2009 Schroeter, 2008 Shankar, 2008 Roberson, 2007 DeMatos, 2001	immunogen = synthetic peptide, central domain 13-28 of Amyloid-beta 1-42 (epitope at 16-23)	monoclonal mouse	ELISA	amyloid-beta	human, mouse (reference: Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, David D, Sinha S, Schlossmacher M, y J, Swindlehurst, C, Nature London 359, 325-327, l992)
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Aβ 40 (poly)	anti-amyloid beta FCA3340 (Frédéric Checler, Centre National de la Recherche Scientifique), Paper Reference: Gandy, 2010	immunogen = synthetic octapeptide Cys-GLMVGGVV, mimicing the C-terminal end of Aβ 40, coupled to either BSA or KLH	polyclonal rabbit	DB, ELISA, IP, WB	amyloid-beta 40; labels leptomeningeal and cortical arterioles;little or no cross with Aβ 42	human, mouse
Aβ 40 (poly)	amyloid-beta R162 (Pankaj Mehta, Department of Immunology, New York State Institute for Basic Research, Staten Island, New York) References: Chung, E, 2010 Schupf, 2008 Sigurdsson, 2001		polyclonal (Sandwich ELISA)	ELISA	amyloid-beta 40	(reference: Mehta P D, Dalton A J, Mehta S P, Kim K S, Sersen E A, Winiewski H M. Neurosci Lett 241:13-16, l998)
Aβ 40, C-terminus (mono)	JRF/cAβ40/10 (Paul Mathews, New York University, School of Medicine, Marc Mercken, Johnson & Johnson Pharm. R&D, Paper) References: Boland, 2010 Trinchese, 2008 Mi, 2007 Razmahel, 2002	immunogen = a peptide corresponding to Aβ residues 36–40 (VGGVV)	monoclonal mouse	ELISA, WB	recognizes the carboxyl terminus of Aβ40; does not detect Aβ1–42 by ELISA or WB, or full-length APP by IP or WB	human, mouse
Aβ 40, C-terminus (mono) IgG₁	BAP-17 (Manfred Brockhaus, F. Hoffmann-La Roche Ltd., Basel, Paper)	immunogen = the peptide CMVGGVV conjugated to keyhole limpet hemocyanin	monoclonal mouse (purified from spent hybridoma medium and conjugated to horseradish peroxidase)	ELISA, FA	specific for Aβ40; no cross-reactivity observed with Ab39, Ab42 or Ab43. Ab41 showed a signal accounting for about 10% of the cognate Ab40 signal	human
Aβ 40, total	amyloid-beta 40 (H. Mori) Reference: Guo J, 2006				total amyloid-beta 40
Aβ 42 (poly)	amyloid-beta R165 (Pankaj Mehta, Department of Immunology, New York State Institute for Basic Research, Staten Island, New York) References: Chung, E, 2010 Schupf, 2008 Sigurdsson, 2001		polyclonal rabbit (Sandwich ELISA)	ELISA	amyloid-beta 42	(reference: Mehta P D, Dalton A J, Mehta S P, Kim K S, Sersen E A, Winiewski H M. Neurosci Lett 241:13-16, l998)
Aβ 42, C terminal (poly)	FCA3542 (Frédéric Checler, Centre National de la Recherche Scientifique), Paper References: Gandy, 2010 Lesné, 2006	immunogen = synthetic octapeptide Cys-MVGGVVIA, mimicing the C-terminal end of Aβ 42, coupled to either BSA or KLH	polyclonal rabbit (serum)	DB, ELISA, IP, WB	recognizes amyloid-beta 42; little or no cross with Aβ 40; intensely labels both diffuse and mature lesions	human, mouse
Aβ 42, C-terminal (mono)	JRF/cAβ42/26 (Marc Mercken, Johnson & Johnson Pharm. R&D, Paper) References: Boland, 2010 Trinchese, 2008 Mi, 2007 Razmahel, 2002	immunogen = the carboxy terminal 10 residues of Ab1-42	monoclonal mouse	ELISA	amyloid-beta 42, C-terminus	human, mouse
Aβ 42, C-terminus (mono)	BAP-15 (Manfred Brockhaus, F. Hoffmann-La Roche Ltd., Basel, Paper) Reference: Richter L, 2010	immunogen = the peptide CGGVVIA conjugated to keyhole limpet hemocyanin	monoclonal mouse (purified from spent hybridoma medium and conjugated to horseradish peroxidase)	ELISA, FA	specific for Aβ42; no cross-reactivity observed with Ab39, Ab40 or Ab43. Ab41 showed a signal accounting for about 10% of the cognate Ab42 signal	human
Aβ 42, total	amyloid-beta 42 (H. Mori) Reference: Guo J, 2006				total amyloid-beta 42
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Aβ fibrils (WO1) IgM,κ	WO1 (Brian O'Nuallain, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN) Paper	raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope within aa 1-16)	monoclonal mouse	FA, WB	detects amyloid-beta fibrils; exhibits Ab binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting that Ab is directed against conformational epitopes that only exist in the fibril	human, mouse
Aβ fibrils, APP CTF (WO2) IgM	WO2 (Brian O'Nuallain, Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN) Paper Reference: Villemagne, 2010	raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope at Aβ residues 5–8)	monoclonal mouse	FA, WB	detects amyloid-beta fibrils; exhibits Ab binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting that Ab is directed against conformational epitopes that only exist in the fibril	human, mouse
Aβ protofibrils (mono) Ig	B10AP (G. Habicht et al., Leibnitz institute for Age Research Fritz Lipmann Institute) Reference: Habicht, 2007	conformation sensitive camel VHH-domain B10, which recognizes specifically amyloid fibrils from Alzheimer’s Aβ peptide, but binds only weakly to the freshly dissolved, disaggregated peptide. Genetic fusion of B10 to E. coli alkaline phosphatase, a homodimeric protein (24), leads to a fusion protein dimer that is termed B10AP	monoclonal (purified by nickel chelate chromatography and ion exchange chromatography)	EM, IB, IF, IH	antibody domain distinguishes Aβ amyloid fibrils from disaggregated Aβ peptide as well as from specific Aβ oligomers; binds only to Aβ peptide when it is present in the form of amyloid fibrils or protofibrils but not when it is freshly dissolved and putatively monomeric; possesses functional activity in preventing the formation of mature amyloid fibrils by stabilizing Aβ protofibrils	human
Aβ x-40, C terminal (poly)	αAβC40 J. Buxbaum, Mt. Sinai School of Medicine, NewYork, NY Paper References: Hashimoto, 2010 Lord, 2009 Näslund, 2000	immunogen = peptide corresponding to the 6 Cterminal residues of Abx-40 and containing N-terminal cysteine residues, coupled to KLH	polyclonal rabbit (serum)	ELISA, IB, WB	recognizes amyloid-beta x-40	human, mouse
Aβ x-42, C terminal (poly)	αAβC42 J. Buxbaum, Mt. Sinai School of Medicine, NewYork, NY Paper References: Hashimoto, 2010 Lord, 2009 Näslund, 2000	immunogen = peptide corresponding to the 6 Cterminal residues of Abx-42 and containing N-terminal cysteine residues, coupled to KLH	polyclonal rabbit (serum)	ELISA, IB, WB	recognizes amyloid-beta x-42	human, mouse
Aβ, N-terminal (1E8)	1E8 (Paul Cutler, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK paper: Cutler, et al, l997)	immunogen = the derived peptide sequence aa. 13–22, (epitope at aa. 18-22, VFFAE) of beta amyloid	monoclonal mouse	ELISA, IB, IH, IP	reacts with the N terminal of amyloid-beta; recognizes Aβ[1–40], Aβ[1–42] and Aβ[1–43]	human, bovine
Aβ[4-10] and APPβ (W0-2) IgG_2a	(Konrad Beyreuther, Center of Molecular Biology, University of Heidelberg, Heidelberg, Germany) Paper Reference: Kuhn, 2010	immunogen = decapeptides overlapping each other by one amino acid, covering residues 1-42 of Aβ (epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide)	monoclonal mouse	ELISA, IH, WB	High affinity to Amyloid peptides Aβ 1-38, Aβ 1-39, Aβ 1-40	human, guinea pig (not rat)
Aβ_1-40 (12H7)	12H7 (Johnson -Wood, Athena Neurosciences Co, San Francisco, CA paper:Johnson-Wood, et al. PNAS, Feb. 18, l997)	immunogen = the peptide sequence aa. 33-42 of beta amyloid, coupled to sheep anti-mouse IgG	monoclonal mouse	ELISA, RIA	reacts with amyloid-beta 42 (recognizes amino acids 33-42); no cross-reactivity with Aβ_1–40
Aβ_1-40 (2G3)	amyloid-beta 40 (Johnson -Wood, Athena Neurosciences Co, San Francisco, CA papers: Citron, et al. PNAS, Nov. 12, 1996, and Johnson-Wood, et al. PNAS, Feb. 18, l997) References: Okereke, 2009 Li, 2009 Serneels, 2009 Brody, 2008 Shankar, 2008 DeMatos, 2001, Buttini, 2002	immunogen = the peptide NH₂-CYS-NH-CH₂-(CH₂)₅-CO-GLMVGGVV-COOH coupled to sheep anti-mouse IgG	monoclonal mouse	ELISA	amyloid-beta 40 (recognizes amino acids 33-40); no cross-reactivity with Aβ_1–42
Aβ_1-42 (10G4)	anti-amyloid beta 10G4 papers: 1) Yang, F., Mak, K., Vinters, H.V., Frautschy, S.A., Cole, G.M., 1994. Monoclonal antibody to the C-terminus of beta-amyloid. NeuroReport 5, 2117–2120 2) Mak, Yang et al., 1994, "Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum" Reference: Eslami, 2008	(anti 5-13 of myloid-beta)	monoclonal mouse	IP, WB	amyloid-beta; recognizes Aβ 42; does not recognize Aβ 40
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Aβ_1-42 (21F12)	anti-amyloid beta 21F12 (Frederique Bard, Elan Pharmaceuticals, So. San Francisco, CA Paper: Johnson-Wood, et al, PNAS February 18, 1997) References: Siderowf, 2010 Okereke, 2009 Serneels, 2009 Brody, 2008 Holmes, 2008 Shankar, 2008 Roberson, 2007 Salehi, 2006	immunogen = synthetic peptide fragment derived from different regions of amyloid-beta and coupled to a carrier protein	monoclonal	IH, WB	amyloid-beta; recognizes amino acids 33-42; negligible crossreactivity (<0.4%) with Aβ_1–40
Aβ_1-x (266)	m266 (R. B. DeMattos, Washington University School of Medicine, St. Louis, MO paper: DeMattos, et al., PNAS July 17, 2001) References: Kim, 2009 Okereke, 2009 Yan, 2009 Serneels, 2009 Brody, 2008	immunogen = central domain of Aβ, residues 13–28	monoclonal mouse (see Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, IN)	ELISA, IH	amyloid beta	mouse
Aβ38 (kit)	anti-Aβ38 (Pankaj Mehta, Department of Immunology, New York State Institute for Basic Research, Staten Island, New York) Paper: Potempska A, Mack K, Mehta PD, et al. Quantitation of sub-femtomole amounts of Alzheimer amyloid beta peptides. Amyloid: Int J Clin Invest 1999;16:14-21	immunogen (detection antibody) = peptide hCys-aminohexoanoyl-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-GlyOH	(Sandwich ELISA monoclonal antibody 6E10 (Signet Labs) is used as capture antibody rabbit antiserum to Aβ38 is used as the detection antibody)	ELISA	detects amyloid-beta 38; no reaction to Aβ40 or Aβ42	human
Aβ42, murine (mono)	JRF/rAβ/2 (Paul Mathews, New York University, School of Medicine, Center for Dementia Research) Research paper Reference: Boland, 2010	immunogen = a peptide corresponding to murine Aβ residues 1–15 (DAEFGHDSGFEVRHQ)	monoclonal mouse (liquid, horseradish peroxidase conj.)	ELISA, WB	recognizes mouse but not human Aβ1–40 or Aβ1–42	mouse (not human)
ADDLs (NU-2, NU-1, NU-4)	(William L. Klein, Ph.D. Professor of Neurobiology & Physiology, Cognitive Neurology and Alzheimer's Disease Center Northwestern University Institute for Neuroscience paper Mary P. Lambert, et al, "Monoclonal antibodies that target pathological assemblies of Aβ" full text) Reference: Peng, 2009	Clones were selected for the ability to discriminate Alzheimer's disease from control brains in extracts and tissue sections. Epitope found in assemblies of Abeta1-28 and ADDLs but not in other sequences, including Abeta1-40	monoclonal		recognize Abeta oligomers and fibrils but not the physiologically prevalent Abeta monomer. Immuno- neutralization experiments showed that toxicity and attachment of ADDLs to synapses in culture could be prevented. ADDL-induced reactive oxygen species (ROS) generation was also inhibited
Amyloid β40 (G2-10)	G2-10 Konrad Beyreuther Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg Paper Reference: Villemagne, 2010	immunogen = synthetic peptide corresponding to Aβ40, aa. 33-40 (GLMVGGVV), conjugated with KLH or BSA through a cysteine residue added at the N terminus of the peptides	monoclonal mouse (liquid, purified, PBS, BSA Also see Chemicon MABN11)	FA, IH, WB	recognizes Amyloid β40 at the C-terminus	human, mouse
Amyloid β42 (G2-11)	G2-11 Konrad Beyreuther Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg Paper Reference: Villemagne, 2010	immunogen = synthetic peptide corresponding to Aβ42, aa. 35-42 (MVGGVVIA), conjugated with KLH or BSA through a cysteine residue added at the N terminus of the peptides	monoclonal mouse (liquid, purified, PBS, BSA Also see Chemicon MABN12)	FA, IH, WB	recognizes Amyloid β42 at the C-terminus	human, mouse
Amyloid fibrils and fibrillar oligomers (poly)	OC (paper on antibodies; paper on oligimerization; Charles G Glabe, University of California, Irvine) References: Lefterov, 2010 Clinton, 2010 Blurton-Jones, 2009	immunogern = a morphologically homogeneous population of Aβ42 fibrils	polyclonal rabbit (serum)	DB, ELISA, IH, WB	specifically recognizes fibrils, but not random coil monomer or prefibrillar oligomers; also recognizes 100,000 × G soluble fibrillar oligomers ranging in size from dimer to greater than 250 kDa on western blots. The fibrillar oligomers recognized by OC are immunologically distinct from prefibrillar oligomers recognized by A11, even though their sizes overlap broadly	human
Amyloid-β and APP (M3.2) IgG₁	M3.2 (Paul Mathews, New York University, School of Medicine, Center for Dementia Research)	immunogen = synthetic peptide, residues 1-15 of beta- amyloid peptide	monoclonal mouse	ELISA, IH, IP, WB	recognizes Aβ, β-CTF, sAPP-α, full length APP	mouse
Amyloid-β protofibrils (mono) IgG_2a	mAb158 (Hillevi Englund, Department of Public Health/Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden) References: Lord, 2009 Englund, 2007. Recently, Anna Lord reported that the mAb158 sandwich ELISA detects synthetic protofibrils, as well as protofibrils in biological samples from a variety of mouse models	immunogen = 30 μg Aβ1–42 Arc protofibrils	monoclonal (supernatant, protein-G purified)	ELISA, IB, WB	beta amyloid protofibrils; does not bind to other amyloids or to amyloid precursor protein (APP). The conformation selectivity of mAb158 is exclusive for amyloid-β (Aβ) as it did not display any binding to other amyloid fibrils; mAb158 did not immuno precipitate α-APPs from cell media or full-length APP from mouse brain homogenate; binds to Aβ fibrils in addition to oligomeric Aβ; has some cross-reactivity with monomeric Aβ	human
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
Amyloid-β protofibrils (mono) IgG₁	mAb1C3 (Hillevi Englund, Department of Public Health/Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden) References: Lord, 2009 Englund, 2007	immunogen = 30 μg Aβ1–42 Arc protofibrils	monoclonal (supernatant, protein-G purified)	ELISA, IB, WB	affinity for Aβ protofibrils, Aβ Arc protofibrils, LMW-Aβ, and Aβ1–16; mAb1C3 did not show any conformation selectivity	human
Amyloid-β, 1-12 (26D6)	S Soriano, 2001 Paper, JBC online References: Burton, 2008 Galvan, 2006	(epitope at amino acids 1-12)	monoclonal mouse	ELISA, WB	Amyloidβ, 1-12
Artic Aβ (mono)	mAb27 (Lars Nilsson, Department of Public Health and Caring Sciences/Molecular Geriatrics, Uppsala University, Uppsala, Sweden Paper, Anna Lord. Reference: Lord, 2009	epitope in the mid-domain of the Arctic Aβ peptide	monoclonal mouse	ELISA	amyloid-beta	human, mouse
protofibrillar Aβ (13C3)	amyloid beta 13C3 (lab of Dr. Richard Mayeux, Joseph P. Mailman School of Public Health, Columbia University, New York, NY) Reference: Schupf N, 2008	immunogen = NaOH-treated synthetic Aβ42 peptides (American Peptide), polymerized to form fibrilliar protein structures	monoclonal (supernat, ELISA screened)	ELISA, IH	reacts with the protofibrillar Aβ42 fractions but not with the LMW fractions of amyloid-beta	human, mouse
soluble Amyloid oligomers (poly)	A11 (paper comparing A11 and OC antibodies; source paper for A11; Charles G Glabe, University of California, Irvine) References: Lefterov, 2010	immunogen = soluble Amyloid oligomers	polyclonal rabbit (serum)	DB, ELISA, IH, WB	generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques or other plaque types. Stains Ab and polyQ prefibrillar oligomers.	human
From the Manufacturers
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
β Amyloid (DE2B4) IgG₁	Novus Biologicals Cat# NB600-698	immunogen = synthetic peptide, corresp. to aa 1 - 17 of human β-Amyloid	monoclonal mouse (liquid, ascites, PBS, azide, protein-G purified)	IH(P)	recognizes β-amyloid (1-17)	human (others not tested)
β Amyloid (poly) IgG	Novus Biologicals Cat# NB100-65661	Immunogen = synthetic peptide corresp. to aa seq. 1-14 of human Amyloid Beta protein	polyclonal rabbit (liquid, antisera, azide)	ELISA, IH(P)	recognizes β-Amyloid (87kDa)	human
β Amyloid (poly) IgG	Novus Biologicals Cat# NBP1-32081	Immunogen = recombinant protein fragment contain a sequence corresp. to a region within aa602 and 757 of human APP	polyclonal rabbit (liquid, Tris-glycine saline, Thimerosal, affinity purified)	WB	recognizes β-Amyloid (87kDa)	human
β Amyloid 1-40 (poly) IgG	Novus Biologicals Cat# NSB-136	immunogen = synthetic peptide, corresp. to aa 1-40 of human β-Amyloid	polyclonal rabbit (liquid, PBS, no preservative)	ELISA, IH, RIA	β-Amyloid	human (others not tested)
β Amyloid 1-40 (poly) IgG	Novus Biologicals Cat# NB100-63284		polyclonal rabbit (liquid, antisera, azide)	ELISA, IH(P), WB	recognizes β-Amyloid (1-40)
β Amyloid 1-40 (poly) IgG	Novus Biologicals Cat# NB100-63285		polyclonal rabbit (liquid, antisera, azide)	ELISA, IH(P), WB	recognizes β-Amyloid (1-40)	human (others not tested)
β Amyloid 1-40 (poly) IgG	Novus Biologicals Cat# NB120-12265	immunogen = C-terminal Synthetic peptide (Human) conjugated to KLH	polyclonal rabbit (liquid, antisera, PBS, azide, affinity purified)	IH, WB	recognizes β-Amyloid (1-40) of amyloid plaques in AD brains	human (others not tested)
β Amyloid 1-40 (poly) IgG	Novus Biologicals Cat# NBP1-05000	immunogen = synthetic peptide containing aa1-40 of amyloid	polyclonal rabbit (lyophilized, no preservative, affinity purified)	WB	recognizes β-Amyloid (1-40)
β Amyloid 40 (poly) IgG	Novus Biologicals Cat# NSB3489		polyclonal rabbit (liquid, antisera, PBS, azide, protein-G purified, Biotin conj.)	DB, ELISA, RIA, WB	recognizes β-Amyloid 40; no significant cross reactivity to Aβ42	human (expect mouse, rat, pig, cow, sheep, dog, rabbit, frog and polar bear)
β Amyloid 40 (poly) IgG	Novus Biologicals Cat# NB300-225	immunogen = synthetic peptide corresponding to amino acid residues G L M V G G V V	polyclonal rabbit (liquid, whole antisera, azide)	IP, WB	reacts with Aβ 40; no cross reactivity with Aβ 42	human, mouse (others not tested)
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
β Amyloid 42 (poly) IgG	Novus Biologicals Cat# NB300-226	immunogen = whole peptide of Aβ 42	polyclonal rabbit (liquid, whole antisera, azide)	IP, WB	reacts with Aβ 42; minimal cross reactivity with Aβ 40	human, mouse (others not tested)
β Amyloid 42 (poly) IgG	Novus Biologicals Cat# NBP1-05001	immunogen = synthetic peptide containing C-terminal domain of Amyloid beta (37-42).	polyclonal rabbit (lyophilized, no preservative, affinity purified)	ELISA	recognizes β-Amyloid 42
β Amyloid A4 (NT) (19H11) IgG₁	Autogen Bioclear cat# ABT117	immunogen = N-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, supernatant, PBS, azide, PEG, sucrose, purified, conj. biotin)	ELISA, WB	recognizes the free N-terminal of amyloid beta 4 with high preference; minor cross reaction with APP	human
β Amyloid A4 (CT) (5C3) IgG₁	Autogen Bioclear cat# ABT102	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, IF, WB	amyloid beta 1-40; no cross reaction with beta amyloid 1-42	human
β Amyloid A4 (CT) (5C3) IgG₁	Autogen Bioclear cat# ABT103	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, purified, conj. biotin)	ELISA, IF, WB	amyloid beta 1-40; no cross reaction with beta amyloid 1-42	human
β Amyloid A4 (CT) (5C3) IgG₁	Autogen Bioclear cat# ABT104	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, purified, conj. FITC)	IC, IF	amyloid beta 1-40; no cross reaction with beta amyloid 1-42	human
β Amyloid A4 (NT) (11H3) IgG₁	Autogen Bioclear cat# ABT115	immunogen = N-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, WB	N-terminus of beta-amyloid 4; no cross reaction with APP	human
β Amyloid A4 (NT) (19H11) IgG₁	Autogen Bioclear cat# ABT116	immunogen = N-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, IF, WB	beta-amyloid	human
β Amyloid A4 (NT) (19H5) IgG₁	Autogen Bioclear cat# ABT118	immunogen = N-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, PEG, sucrose, purified)	ELISA, WB	N-terminus of beta-amyloid 4; crossreacts with APP	human
β Amyloid A4 (NT) (19H5) IgG₁	Autogen Bioclear cat# ABT119	immunogen = N-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, PEG, sucrose, purified, conj. biotin)	ELISA, WB	N-terminus of beta-amyloid 4; crossreacts with APP	human
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
β Amyloid A4 (NT) (7F4) IgG₁	Autogen Bioclear cat# ABT113	immunogen = peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, WB	recognizes the free N-terminus of beta-amyloid 4; no cross reaction with APP	human
β Amyloid A4 (NT) (7F9) IgG₁	Autogen Bioclear cat# ABT114	immunogen = peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, WB	recognizes the free N-terminus of beta-amyloid 4; no cross reaction with APP	human
β Amyloid A4 1-42 (CT) (6G12) IgG₁	Autogen Bioclear cat# ABT112	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, purified, conj. biotin)	ELISA, WB	amyloid beta 1-42; no cross reaction with beta amyloid 1-40	human
β Amyloid A4 1-42 (CT) (8G7) IgG₁	Autogen Bioclear cat# ABT108	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, IC, WB	endogenous amyloid beta 1-42; no cross reaction with beta amyloid 1-40	human
β Amyloid A4 1-42 (CT) (8G7) IgG₁	Autogen Bioclear cat# ABT109	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, purified, conj. biotin)	ELISA, IF, WB	amyloid beta 1-42; no cross reaction with beta amyloid 1-40	human
β Amyloid A4 1-42 (CT) (8G7) IgG₁	Autogen Bioclear cat# ABT110	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (liquid, PBS, azide, purified, conj. FITC)	IF	amyloid beta 1-42; no cross reaction with beta amyloid 1-40	human
β Amyloid A4 1-43 (CT) (6G12) IgG₁	Autogen Bioclear cat# ABT111	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse	ELISA, WB	β Amyloid A4 1-43 (CT)	human
β Amyloid A4 40/42 (CT) (9F1) IgG₁	Autogen Bioclear cat# ABT105	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, PBS, azide, PEG, sucrose, purified)	ELISA, IF, WB	beta-amyloid 40/42	human
β Amyloid A4 40/42 (CT) (9F1) IgG₁	Autogen Bioclear cat# ABT106	immunogen = peptide conj. to KLH	monoclonal mouse (lyophilized, supernatant, PBS, azide, PEG, sucrose, purified, conj. biotin)	ELISA, IF, WB	C-terminal of amyloid beta 1-40 and 1-42	human
β Amyloid A4 40/42 (CT) (9F1) IgG₁	Autogen Bioclear cat# ABT107	immunogen = C-terminal peptide conj. to KLH	monoclonal mouse (lyophilized, supernatant, PBS, azide, PEG, sucrose, purified, conj. FITC)	IF	C-terminal of amyloid beta 1-40 and 1-42; cross reacts with APP	human
Antigen (Clone) IgG	Distributor (Producer)	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
β-Amyloid (19B8) IgG_2a	Abcam Cat# ab17250	immunogen = synthetic peptide: R H D S G Y E V H H Q K, corresp. to aa 5-16 of human β-Amyloid coupled to S3 + epinephrine	monoclonal mouse (liquid, PBS, azide, protein A purified)	ELISA	β-Amyloid; binding depends on the presence of at least aa residues 9-10	human (others not tested; expect cynomolgus, guinea pig, rabbit, pig, sheep, dog, cow, chicken)
β-Amyloid (3G5) IgG₁, κ	Abcam Cat# ab17905	immunogen = a 28 aa synthetic peptide, derived from human β-Amyloid peptide	monoclonal mouse (liquid, PBS, azide)	ELISA, WB	β-amyloid peptide; high concentrations of antibody will also react with A-a, B-a and g subunits of fibrinogen	human (others not tested)
β-Amyloid (6F/3D) IgG₁	Abcam Cat# ab49455	immunogen = synthetic peptide representing a site on the human beta amyloid molecule	monoclonal mouse (liquid, supernatant, azide)	IH(P); not IH(F)	β-Amyloid	human
β-Amyloid (DE2B4) IgG₁	Abcam Cat# ab11132	immunogen = synthetic peptide, corr. to aa 1-17 of human β-Amyloid	monoclonal mouse (liquid, supernate, protein-G purified, PBS, azide)	IC, IF, IH(P), IP, WB	detects extracellular amyloid beta with senile plaques and vessel amyloid in Alzheimer disease brain.	human (others not tested)
β-Amyloid (poly) IgG	Abcam Cat# ab2539	immunogen = synthetic peptide D A E F R D S G Y E V H H, conj. to KLH, corr. to aa 1-14 of human beta Amyloid	polyclonal rabbit (liquid, KPBS, azide, affinity purified, sterile filtered)	ELISA, WB	β-Amyloid	human, mouse (others not tested)




	1 to 100 of 617 results





			Print this page Email this page Alzforum News Papers of the Week Text size Share & Bookmark Del.icio.us Digg Facebook Google Newsvine






			Antibody Links

			Antibody Background Methods Glossary Submit New Antibody Search Companies Candidate Antigen List Biosci Register





			Antibody-Search Websites

			1DegreeBio Inc. Abcam Antibodies Online AntiBody&BeYond Antibodypedia Antibody Resource Biocompare Exact Antigen Immunoportal Linscott's Directory







			Antibodies Cell Lines Collaborators Papers Research Participants








			An up-to-date collection of all published AD genetic association studies.