Antibody Directory

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Antibodies to Amyloid Beta and related Proteins
From the Laboratories
Antigen (Clone) IgG	Name (Source) used in	Immunogen (Epitope)	Host (Formulation)	Methods glossary	Specificity	Reactivity top
β-Amyloid oligomers (NU-1)	anti β-Amyloid oligomers (paper, Mary Lambert et al., Northwestern University, Evanston, IL, USA) References: Varvel, 2009 Jimenez, 2008	immunogern = Aβ oligomers (amyloid β-derived diffusible ligands, ADDLs), mixed with Freund's adjuvant (we suggest that the NU-1 and NU-4 epitope is three-dimensional, in which aggregation of Aβ1–28 to form a dimer is necessary to align correct amino acids in the binding pocket, perhaps several from each single peptide)	monoclonal mouse	DB, WB	strong preferential binding for Aα oligomers over monomers; neutralizes binding of endogenous and synthetic ADDLs to cultured cells; binds strongly to Alzheimer's disease brain samples but not to control brain samples; reactivity prominent in the hippocampus, entorhinal cortex, and middle frontal gyrus of Alzheimer's disease brain	human, mouse





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			An up-to-date collection of all published AD genetic association studies.