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Home: Research: Compendia: Antibodies
 Antibody Directory
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Important Notice: We are striving to include as many companies or products as possible, but we do not make a claim to being comprehensive. We may inadvertently omit specific companies or products due to a lack of information.
Antibodies to Amyloid Beta and related Proteins
From the Laboratories
Antigen
(Clone)
IgG		 Name
(Source)
used in		 Immunogen
(Epitope)		 Host
(Formulation)		 Methods
glossary		 Specificity      Reactivity     top
Aβ protofibrils
(mono)
Ig 		B10AP
(G. Habicht et al., Leibnitz institute for Age Research Fritz Lipmann Institute)
Reference:
Habicht, 2007		 conformation sensitive camel VHH-domain B10, which recognizes specifically amyloid fibrils from Alzheimer’s Aβ peptide, but binds only weakly to the freshly dissolved, disaggregated peptide. Genetic fusion of B10 to E. coli alkaline phosphatase, a homodimeric protein (24), leads to a fusion protein dimer that is termed B10AP  monoclonal
(purified by nickel chelate chromatography and ion exchange chromatography) 		 EM, IB, IF, IH  antibody domain distinguishes Aβ amyloid fibrils from disaggregated Aβ peptide as well as from specific Aβ oligomers; binds only to Aβ peptide when it is present in the form of amyloid fibrils or protofibrils but not when it is freshly dissolved and putatively monomeric; possesses functional activity in preventing the formation of mature amyloid fibrils by stabilizing Aβ protofibrils  human 
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