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Home: Research: Compendia: Antibodies
 Antibody Directory
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Important Notice: We are striving to include as many companies or products as possible, but we do not make a claim to being comprehensive. We may inadvertently omit specific companies or products due to a lack of information.
Antibodies to Amyloid Beta and related Proteins
From the Laboratories
Antigen
(Clone)
IgG		 Name
(Source)
used in		 Immunogen
(Epitope)		 Host
(Formulation)		 Methods
glossary		 Specificity      Reactivity     top
ADDLs
(NU-2, NU-1, NU-4)
 (William L. Klein, Ph.D. Professor of Neurobiology & Physiology, Cognitive Neurology and Alzheimer's Disease Center Northwestern University Institute for Neuroscience
paper
Mary P. Lambert, et al, "Monoclonal antibodies that target pathological assemblies of Aβ" full text)
Reference:
Peng, 2009 		Clones were selected for the ability to discriminate Alzheimer's disease from control brains in extracts and tissue sections. Epitope found in assemblies of Abeta1-28 and ADDLs but not in other sequences, including Abeta1-40  monoclonal
 		   recognize Abeta oligomers and fibrils but not the physiologically prevalent Abeta monomer. Immuno- neutralization experiments showed that toxicity and attachment of ADDLs to synapses in culture could be prevented. ADDL-induced reactive oxygen species (ROS) generation was also inhibited   
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