Brain Cholesterol Pathology is the Cause of Alzheimer's Disease
By Alexei R. Koudinov and Natalia V. Koudinova, Neurobiology of Lipids, Russian Academy of Medical Sciences
Posted 19 August 2002
We propose that cholesterol homeostasis biological misregulation itself has a key role for synaptic plasticity impairment,
neuronal degeneration and is the primary cause for several Alzheimer's hallmarks not limited to brain amyloid. Moreover,
Alzheimer's changes in neurochemistry of amyloid b tau, neuronal cytoskeleton, and oxidative stress reactions represent
physiological transitory mechanisms aiming to compensate impaired brain cholesterol dynamics and/or associated neurotransmission
and synaptic plasticity failure.
To see the full text of our article in Clinical Medicine and Health Research NetPrints (27 November 2001),
download the PDF or go to this link:
http://clinmed.netprints.org/cgi/content/full/2001100005v1
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